Browse our GNAI1 Proteins (GNAI1)

Full name:
Guanine Nucleotide Binding Protein (G Protein), alpha Inhibiting Activity Polypeptide 1 Proteins (GNAI1)
On www.antibodies-online.com are 12 Guanine Nucleotide Binding Protein (G Protein), alpha Inhibiting Activity Polypeptide 1 (GNAI1) Proteins from 5 different suppliers available. Additionally we are shipping GNAI1 Antibodies (67) and many more products for this protein. A total of 83 GNAI1 products are currently listed.
Synonyms:
AU046200, BPGTPB, Gi, Gialpha1, Gnai-1, gnai1, zgc:63957
list all proteins Gene Name GeneID UniProt
GNAI1 14677 B2RSH2
GNAI1 2770 P63096
GNAI1 25686 P10824

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GNAI1 Proteins (GNAI1) by Origin

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Top referenced GNAI1 Proteins

  1. Human GNAI1 Protein expressed in Escherichia coli (E. coli) - ABIN667567 : Simon, Strathmann, Gautam: Diversity of G proteins in signal transduction. in Science (New York, N.Y.) 1991 (PubMed)
    Show all 2 references for 667567

More Proteins for GNAI1 Interaction Partners

Mouse (Murine) Guanine Nucleotide Binding Protein (G Protein), alpha Inhibiting Activity Polypeptide 1 (GNAI1) interaction partners

  1. stimulation of GPR17 (show GPR17 Proteins) by the small molecule agonist MDL29,951 (2-carboxy-4,6-dichloro-1H-indole-3-propionic acid) decreases myelin basic protein (show MBP Proteins) expression levels mainly by triggering the Galphai/o signaling pathway.

  2. Gnai1 missense mutation is responsible of hyperpigmentation in mouse model.

  3. acidosis in inflamed tissues may be a decisive factor to regulate switching of PKA and PKCepsilon dependence via proton-sensing G-protein-coupled receptors.

  4. Data show that guanine nucleotide-binding protein G(i) subunit alpha-1 and alpha-3 (Galphai1/3) can interact with CD14 antigen/Grb2-associated binding protein Gab1, which modulates macrophage polarization in vitro and in vivo.

  5. By using mice deficient in individual Galphai/o G-protein subunits, authors demonstrate that Galphai1 and Galphai3 are the critical in vivo targets of ADP-ribosylation underlying vasoactive amine sensitization elicited by pertussis toxin exposure.

  6. leucine can directly facilitate insulin (show INS Proteins) signaling through a Galphai protein-dependent intracellular signaling pathway

  7. Inactive Galpha(i1)-GDP enhances the affinity of RGS14 for H-Ras-GTP in live cells, resulting in a ternary signaling complex that is further regulated by G protein-coupled receptors.

  8. Mice with mutations of Gnai1 or Gnai2 (show GNAI2 Proteins) have neither fusions of ribs nor lumbar vertebrae, but loss of both Gnai3 (show GNAI3 Proteins) and one of the other two genes increases the number and severity of rib fusions without affecting the lumbar fusions.

  9. Results suggest a model in which the Gbetagamma dimer that is released as a result of the dissociation from Galpha(o (show GNAO1 Proteins)) upon activation of mGluR6 (show GRM6 Proteins) closes the TRPM1 (show TRPM1 Proteins) channel, perhaps via a direct interaction.

  10. RGS14 (show RGS16 Proteins) can form complexes with GPCRs in cells that are dependent on Galpha (show SUCLG1 Proteins)(i/o) and these RGS14 (show RGS16 Proteins).Galpha (show SUCLG1 Proteins)(i1).GPCR (show GPBAR1 Proteins) complexes may be substrates for other signaling partners such as Ric-8A (show RIC8A Proteins)

Human Guanine Nucleotide Binding Protein (G Protein), alpha Inhibiting Activity Polypeptide 1 (GNAI1) interaction partners

  1. These data indicate that, unlike in taste cells, TAS2Rs couple to the prevalent G proteins, Galphai1, Galphai2 (show GNAI2 Proteins), and Galphai3 (show GNAI3 Proteins), with no evidence for functional coupling to Galphagust.

  2. testosterone rapidly increased whole-cell HCAEC SKCa and BKCa (show KCNMA1 Proteins) currents via a surface androgen receptor (show AR Proteins), Gi/o protein, and protein kinase A

  3. These findings suggest that Gi1 interacts only with active GPCRs and that the well known high speed of GPCR signal transduction does not require preassembly between G proteins and GPCRs.

  4. CGRP (show S100A12 Proteins) family of receptors displays both ligand- and RAMP-dependent signaling bias among the Galphas (show GNAS Proteins), Galphai, and Galphaq (show GNAQ Proteins)/11 pathways.

  5. biochemical and computational data indicate that the interactions between alpha5, alpha1, and beta2-beta3 are not only vital for GDP release during G protein activation, but they are also necessary for proper GTP binding (show RND2 Proteins) (or GDP rebinding).

  6. Data indicate that hydroxyurea (HU) induces SAR1 protein expression, which in turn activates gamma-globin (show HBG1 Proteins) expression, predominantly through the Gialpha/JNK (show MAPK8 Proteins)/Jun (show JUN Proteins) pathway.

  7. Gi alpha subunit (show POLG Proteins) was found to be a key modulator of GABAB-receptors signaling in analgesia.

  8. AC5, by binding active Galphai1, interferes with G-protein deactivation and reassembly and thereby might sensitize its own regulation.

  9. Data indicate that focal adhesion kinase (FAK) activation and cell migration require Src, Gi/Go, COX-2 and LOXs activities.

  10. resistin (show RETN Proteins) contributes to the pro-inflammatory state of SMC (show DYM Proteins) by the up-regulation of CX3CL1 (show CX3CL1 Proteins) and CX3CR1 (show CX3CR1 Proteins) expression via a mechanism involving NF-kB, AP-1 (show FOSB Proteins), and STAT1 (show STAT1 Proteins)/3 transcription factors, (2) resistin (show RETN Proteins) employs TLR4 (show TLR4 Proteins) and Gi-protein signaling.

GNAI1 Protein Profile

Protein Summary

Guanine nucleotide binding proteins are heterotrimeric signal-transducing molecules consisting of alpha, beta, and gamma subunits. The alpha subunit binds guanine nucleotide, can hydrolyze GTP, and can interact with other proteins. The protein encoded by this gene represents the alpha subunit of an inhibitory complex. The encoded protein is part of a complex that responds to beta-adrenergic signals by inhibiting adenylate cyclase. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with GNAI1

  • guanine nucleotide binding protein (G protein), alpha inhibiting 1 (Gnai1)
  • guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 (gnai1-b)
  • guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 (GNAI1)
  • guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 (Gnai1)
  • guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 (gnai1)
  • AU046200 protein
  • BPGTPB protein
  • Gi protein
  • Gialpha1 protein
  • Gnai-1 protein
  • gnai1 protein
  • zgc:63957 protein

Protein level used designations for GNAI1

adenylate cyclase-inhibiting G alpha protein , guanine nucleotide binding protein, alpha inhibiting 1 , guanine nucleotide-binding protein G(i) subunit alpha-1 , Gi1 protein alpha-subunit , alpha-subunit of G-protein, type G-alpha-i-1 , guanine nucleotide-binding protein G(i), alpha-1 subunit , Gi1 protein alpha subunit , Gi-alpha-1 protein , guanine nucleotide binding protein (G protein), alpha inhibiting 1 , Galpha i1a

GENE ID SPECIES
14677 Mus musculus
100135528 Cavia porcellus
399463 Xenopus laevis
396368 Gallus gallus
2770 Homo sapiens
397505 Sus scrofa
281790 Bos taurus
25686 Rattus norvegicus
393946 Danio rerio
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