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Human Aggrecan ELISA Kit for Sandwich ELISA - ABIN415094
Li, Liang, Tao, Zhou, Li, Chen, Chen: Acidic pH conditions mimicking degenerative intervertebral discs impair the survival and biological behavior of human adipose-derived mesenchymal stem cells. in Experimental biology and medicine (Maywood, N.J.) 2012
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Rat (Rattus) Aggrecan ELISA Kit for Sandwich ELISA - ABIN432406
Torricelli, Veronesi, Pagani, Maffulli, Masiero, Frizziero, Fini: In vitro tenocyte metabolism in aging and oestrogen deficiency. in Age (Dordrecht, Netherlands) 2013
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The features of AGC1 structure and function in physiology and pathology, regulation by calcium, dependency on mitochondrial membrane potential, role in cancer cells, and tissue specificity are reviewed. AGC1 is involved in the glutamate (show GRIN1 ELISA Kits)-mediated excitotoxicity in neurons and AGC gene or protein alterations were discovered in rare human diseases. Review.
Chondrogenic potential was higher and Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signaling was more potently activated by a GSK-3beta (show GSK3b ELISA Kits) inhibitor in the posterior than in the anterior part of the human infant sclera.
single nucleotide variants of ACAN and their haplotypes are associated with the severity of lumbar disc herniation.
Four of 29 small for gestational age children with advanced bone age had an ACAN gene mutation (13.8%). Mutations were related to additional characteristics: midface hypoplasia, joint problems, and broad great toes.
SNVs of candidate genes in ACAN metabolic pathway are associated with severity of Lumbar disc degeneration and Modic changes in patients with chronic mechanical low back pain.
Heterozygous aggrecan mutations result in a phenotypic spectrum ranging from mild and proportionate short stature to a mild skeletal dysplasia with disproportionate short stature and brachydactyly.
deacetylation promotes SOX9 (show SOX9 ELISA Kits) nuclear translocation and hence its ability to activate ACAN.
Femoral and tibial cartilage show a different behaviour concerning expression values for the genes Col1A1 (show COL1A1 ELISA Kits), Col2A1 (show COL2A1 ELISA Kits) and Agg.
The genotype and allele frequencies of the COL2A1 (show COL2A1 ELISA Kits) genetic polymorphisms (rs1793953 and rs2276454) and the Aggrecan VNTR polymorphisms differed significantly between the case group and the control group.the genotype and allele frequencies of the COL2A1 (show COL2A1 ELISA Kits) genes, rs1793953 and rs2276454, and Aggrecan VNTR significantly differed in terms of Pfirrmann grades III, IV, and V
Decrease in mRNA expression of ACAN is associated with Osteoarthritis.
the subsequent presentation of aggregan from ECM (show MMRN1 ELISA Kits) leads to CD4 (show CD4 ELISA Kits)(+) T-cell activation and effector cell formation.
Data show that expression of mRNAs for aggrecan, collagen type II, and versican (show Vcan ELISA Kits) were significantly effected by the intervention.
The delayed activation of proMMPs and the relatively low cleavage efficiency of MMPs compared to ADAMTS5 (show ADAMTS5 ELISA Kits) (aggrecanase (show ADAMTS4 ELISA Kits)) explains the minor contribution of the MMP enzymes to aggrecan catabolism in vivo.
Self-adhesion between highly negatively charged aggrecan macromolecules extracted from bovine cartilage extracellular matrix, was investigated.
aggrecanase (show ADAMTS4 ELISA Kits) activity (a) is responsible for early TNFalpha (show TNF ELISA Kits)-dependent aggrecan cleavage and GAG release in the meniscus and (b) might be involved in meniscal degeneration.
Maintenance of structure and organization of extracellular matrix comprising chondron and pericellular microenvironment of chondrocytes in articular cartilage is important for distribution of newly synthesized aggrecan monomers within tissue.
aggrecan plays a protective role in preventing degradation of collagen fibrils
Changes in aggrecan and type II collagen (show COL2A1 ELISA Kits) promoter activity in transfected chondrocyte-laden cylindrical constructs were evaluated in response to a range of loading frequencies and durations.
AGC1 mRNA expression level was upregulated by multidirectional articular motion.
Homozygosity mapping in candidate regions in a small Dexter pedigree suggested aggrecan as the most likely candidate gene. Mutation screening revealed a 4-bp insertion in exon 11 (2266_2267insGGCA) and a second, rarer transition in exon 1 (-198C>T).
As the primary site of agc1-deficiency is neuronal, this explains the lack of accumulation of brain lactate in agc1-deficiency in humans and mice.
Aggrecan has a major role in regulating the expression of key growth factors and signaling molecules during development of cartilaginous tissue and is essential for proper chondrocyte organization, morphology, and survival.
Aggrecan, link protein (show HAPLN1 ELISA Kits) and TN-R (show TNR ELISA Kits) were identified to be essential for the neuroprotective properties of the perineuronal net.
Runx3 (show RUNX3 ELISA Kits) positively regulates aggrecan expression and suggest that its function is more limited to cartilage development than to bone.
The role of ADAMTS5 (show ADAMTS5 ELISA Kits) in tendon is to remove pericellular and interfibrillar aggrecan to maintain the molecular architecture responsible for normal tissue function.
role of ADAMTS5 (show ADAMTS5 ELISA Kits) in dermal repair through CD44 (show CD44 ELISA Kits)-mediated aggrecan accumulation and modulation of transforming growth factor beta1 (TGFbeta1 (show TGFB1 ELISA Kits)) signaling
CSGalNAcT-1 is necessary for normal levels of endochondral ossification, and the decrease in CS amount in the growth plate by its absence causes a rapid catabolism of aggrecan.
Data show that strong aggrecan gene expression was observed in growth plate and articular cartilage as well as the fibrocartilage of meniscus, trachea, and intervertebral disc.
A remote upstream element regulates tissue-specific expression of the rat aggrecan gene
At 0.1 and 1 microM concentrations, LE135 weakly but significantly increased chondral morphology scores, compared to untreated controls. Lack of aggrecan expression and lack of increased CII:CI ratio, compared to controls, did not affect chondrogenesis.
degenerative suspensory ligament desmitis ligaments showed a 15-fold increase in aggrecan compared to normal
keratan sulphate in the interglobular domain of pig aggrecan has a microstructure that is distinct from keratan sulphate in the keratan sulphate-rich region
Aggrecan synthesis in intervertebral disc cells is stimulated by E-cadherin (show CDH1 ELISA Kits).
This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene.
aggrecan core protein
, cartilage-specific proteoglycan core protein
, chondroitin sulfate proteoglycan core protein 1
, large aggregating proteoglycan
, aggrecan 1
, aggrecan, structural proteoglycan of cartilage
, aggrecan 1 (chondroitin sulfate proteoglycan 1, large aggregating proteoglycan, antigen identified by monoclonal antibody A0122)
, aggrecan epidermal growth factor-like domain-1
, chondroitin sulfate proteoglycan core protein
, cartilage aggregating proteoglycan
, chondroitin sulfate proteoglycan 1
, large aggregating proteoglycan, antigen
, aggrecan core protein-like
, aggrecan interglobular domain