Browse our Aggrecan Proteins (ACAN)

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Aggrecan Proteins (ACAN)
On www.antibodies-online.com are 22 Aggrecan (ACAN) Proteins from 7 different suppliers available. Additionally we are shipping Aggrecan Antibodies (170) and Aggrecan Kits (66) and many more products for this protein. A total of 262 Aggrecan products are currently listed.
Synonyms:
Agc, Agc1, AGCAN, ARALAR, b2b183Clo, cmd, Cspg1, CSPGCP, MSK16, SEDK
list all proteins Gene Name GeneID UniProt
ACAN 176  
ACAN 11595 Q61282
ACAN 58968 P07897

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Aggrecan Proteins (ACAN) by Origin

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Top referenced Aggrecan Proteins

  1. Human Aggrecan Protein expressed in HEK-293 - ABIN2666766 : Doege, Sasaki, Kimura, Yamada: Complete coding sequence and deduced primary structure of the human cartilage large aggregating proteoglycan, aggrecan. Human-specific repeats, and additional alternatively spliced forms. in The Journal of biological chemistry 1991 (PubMed)
    Show all 5 references for 2666766

More Proteins for Aggrecan Interaction Partners

Human Aggrecan (ACAN) interaction partners

  1. single nucleotide variants of ACAN and their haplotypes are associated with the severity of lumbar disc herniation.

  2. Four of 29 small for gestational age children with advanced bone age had an ACAN gene mutation (13.8%). Mutations were related to additional characteristics: midface hypoplasia, joint problems, and broad great toes.

  3. SNVs of candidate genes in ACAN metabolic pathway are associated with severity of Lumbar disc degeneration and Modic changes in patients with chronic mechanical low back pain.

  4. Heterozygous aggrecan mutations result in a phenotypic spectrum ranging from mild and proportionate short stature to a mild skeletal dysplasia with disproportionate short stature and brachydactyly.

  5. deacetylation promotes SOX9 (show SOX9 Proteins) nuclear translocation and hence its ability to activate ACAN.

  6. Femoral and tibial cartilage show a different behaviour concerning expression values for the genes Col1A1 (show COL1A1 Proteins), Col2A1 (show COL2A1 Proteins) and Agg.

  7. The genotype and allele frequencies of the COL2A1 (show COL2A1 Proteins) genetic polymorphisms (rs1793953 and rs2276454) and the Aggrecan VNTR polymorphisms differed significantly between the case group and the control group.the genotype and allele frequencies of the COL2A1 (show COL2A1 Proteins) genes, rs1793953 and rs2276454, and Aggrecan VNTR significantly differed in terms of Pfirrmann grades III, IV, and V

  8. Decrease in mRNA expression of ACAN is associated with Osteoarthritis.

  9. Results showed an association between short alleles and lumbar disc herniation (LDH), corroborating the hypothesis that aggrecan with shorter repeat lengths can lead to a reduction in the physiological proteoglycan function of intervertebral disc hydration and, consequently, increased individual susceptibility to LDH.

  10. Citrullinated Proteoglycan (show Vcan Proteins) Aggrecan is a new member of citrullinated proteins identified in human joints.

Cow (Bovine) Aggrecan (ACAN) interaction partners

  1. the subsequent presentation of aggregan from ECM (show MMRN1 Proteins) leads to CD4 (show CD4 Proteins)(+) T-cell activation and effector cell formation.

  2. Data show that expression of mRNAs for aggrecan, collagen type II, and versican (show Vcan Proteins) were significantly effected by the intervention.

  3. The delayed activation of proMMPs and the relatively low cleavage efficiency of MMPs compared to ADAMTS5 (show ADAMTS5 Proteins) (aggrecanase (show ADAMTS4 Proteins)) explains the minor contribution of the MMP enzymes to aggrecan catabolism in vivo.

  4. Self-adhesion between highly negatively charged aggrecan macromolecules extracted from bovine cartilage extracellular matrix, was investigated.

  5. aggrecanase (show ADAMTS4 Proteins) activity (a) is responsible for early TNFalpha (show TNF Proteins)-dependent aggrecan cleavage and GAG release in the meniscus and (b) might be involved in meniscal degeneration.

  6. Maintenance of structure and organization of extracellular matrix comprising chondron and pericellular microenvironment of chondrocytes in articular cartilage is important for distribution of newly synthesized aggrecan monomers within tissue.

  7. aggrecan plays a protective role in preventing degradation of collagen fibrils

  8. Changes in aggrecan and type II collagen (show COL2A1 Proteins) promoter activity in transfected chondrocyte-laden cylindrical constructs were evaluated in response to a range of loading frequencies and durations.

  9. AGC1 mRNA expression level was upregulated by multidirectional articular motion.

  10. Homozygosity mapping in candidate regions in a small Dexter pedigree suggested aggrecan as the most likely candidate gene. Mutation screening revealed a 4-bp insertion in exon 11 (2266_2267insGGCA) and a second, rarer transition in exon 1 (-198C>T).

Mouse (Murine) Aggrecan (ACAN) interaction partners

  1. As the primary site of agc1-deficiency is neuronal, this explains the lack of accumulation of brain lactate in agc1-deficiency in humans and mice.

  2. Aggrecan has a major role in regulating the expression of key growth factors and signaling molecules during development of cartilaginous tissue and is essential for proper chondrocyte organization, morphology, and survival.

  3. Aggrecan, link protein (show HAPLN1 Proteins) and TN-R (show TNR Proteins) were identified to be essential for the neuroprotective properties of the perineuronal net.

  4. the subsequent presentation of aggregan from ECM (show MMRN1 Proteins) leads to CD4 (show CD4 Proteins)(+) T-cell activation and effector cell formation.

  5. Runx3 (show RUNX3 Proteins) positively regulates aggrecan expression and suggest that its function is more limited to cartilage development than to bone.

  6. The role of ADAMTS5 (show ADAMTS5 Proteins) in tendon is to remove pericellular and interfibrillar aggrecan to maintain the molecular architecture responsible for normal tissue function.

  7. role of ADAMTS5 (show ADAMTS5 Proteins) in dermal repair through CD44 (show CD44 Proteins)-mediated aggrecan accumulation and modulation of transforming growth factor beta1 (TGFbeta1 (show TGFB1 Proteins)) signaling

  8. CSGalNAcT-1 (show CSGALNACT1 Proteins) is necessary for normal levels of endochondral ossification, and the decrease in CS amount in the growth plate by its absence causes a rapid catabolism of aggrecan.

  9. Data show that strong aggrecan gene expression was observed in growth plate and articular cartilage as well as the fibrocartilage of meniscus, trachea, and intervertebral disc.

  10. A remote upstream element regulates tissue-specific expression of the rat aggrecan gene

Horse (Equine) Aggrecan (ACAN) interaction partners

  1. At 0.1 and 1 microM concentrations, LE135 weakly but significantly increased chondral morphology scores, compared to untreated controls. Lack of aggrecan expression and lack of increased CII:CI ratio, compared to controls, did not affect chondrogenesis.

  2. degenerative suspensory ligament desmitis ligaments showed a 15-fold increase in aggrecan compared to normal

Pig (Porcine) Aggrecan (ACAN) interaction partners

  1. keratan sulphate in the interglobular domain of pig aggrecan has a microstructure that is distinct from keratan sulphate in the keratan sulphate-rich region

Rabbit Aggrecan (ACAN) interaction partners

  1. Aggrecan synthesis in intervertebral disc cells is stimulated by E-cadherin (show CDH1 Proteins).

Aggrecan (ACAN) Protein Profile

Protein Summary

This gene encodes a calcium-binding mitochondrial carrier protein. The encoded protein localizes to the mitochondria and is involved in the exchange of aspartate for glutamate across the inner mitochondrial membrane. Polymorphisms in this gene may be associated with autism, and mutations in this gene may also be a cause of global cerebral hypomyelination. Alternatively spliced transcript variants have been observed for this gene.

Alternative names and synonyms associated with Aggrecan (ACAN)

  • aggrecan (LOC100380783)
  • aggrecan (ACAN)
  • aggrecan (Acan)
  • aggrecan (AGC)
  • solute carrier family 25 (aspartate/glutamate carrier), member 12 (SLC25A12)
  • Agc protein
  • Agc1 protein
  • AGCAN protein
  • ARALAR protein
  • b2b183Clo protein
  • cmd protein
  • Cspg1 protein
  • CSPGCP protein
  • MSK16 protein
  • SEDK protein

Protein level used designations for Aggrecan Proteins (ACAN)

aggrecan , aggrecan core protein-like , aggrecan core protein , cartilage-specific proteoglycan core protein , chondroitin sulfate proteoglycan core protein 1 , large aggregating proteoglycan , CSPCP , aggrecan 1 (chondroitin sulfate proteoglycan 1, large aggregating proteoglycan, antigen identified by monoclonal antibody A0122) , aggrecan epidermal growth factor-like domain-1 , aggrecan 1 , chondroitin sulfate proteoglycan 1 , large aggregating proteoglycan, antigen , aggrecan, structural proteoglycan of cartilage , cartilage aggregating proteoglycan , aggrecan interglobular domain , chondroitin sulfate proteoglycan core protein , araceli hiperlarga , calcium binding mitochondrial carrier superfamily member Aralar1 , calcium-binding mitochondrial carrier protein Aralar1 , mitochondrial aspartate glutamate carrier 1 , solute carrier family 25 (mitochondrial carrier, Aralar), member 12

GENE ID SPECIES
100380783 Salmo salar
100432072 Pongo abelii
176 Homo sapiens
280985 Bos taurus
403828 Canis lupus familiaris
11595 Mus musculus
58968 Rattus norvegicus
100033876 Equus caballus
397255 Sus scrofa
100731672 Cavia porcellus
395798 Gallus gallus
100009079 Oryctolagus cuniculus
100861256 Capra hircus
443001 Ovis aries
101084542 Felis catus
8604 Homo sapiens
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