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CHPF was found to be differentially methylated in human squamous cell carcinomas.
study reports a novel protein named Klokin 1(a splice variant of chondroitin polymerizing factor) that transports Parkin (show PARK2 Proteins) to the mitochondria; findings indicate that mitochondrial Parkin (show PARK2 Proteins) prevents mitochondrial depolarization and that Klokin 1 may compensate for Parkin (show PARK2 Proteins) deficiency
Chondroitin sulfate synthase-2/chondroitin polymerizing factor has two variants with distinct function
chondroitin polymerizing activity requires concomitant expression of a ChPF with ChSy (show CHSY1 Proteins); coexpression of the ChPF and ChSy (show CHSY1 Proteins) yielded markedly augmented glycosyltransferase (show GTDC2 Proteins) activities, whereas simple mixing of the two separately expressed proteins did not.
CSS2 (show CAPNS2 Proteins) mainly participated in the extension of chondroitin sulfate
Has both beta-1,3-glucuronic acid and beta-1,4-N- acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Specific activity is much reduced compared to CHSY1 (By similarity).
chondroitin polymerizing factor
, chondroitin sulfate synthase 2
, chondroitin sulfate synthase 2-like
, N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase II
, N-acetylgalactosaminyltransferase 2
, chondroitin glucuronyltransferase 2
, chondroitin-polymerizing factor
, glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase II
, N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 3
, N-acetylgalactosaminyltransferase 3
, carbohydrate synthase 2
, chondroitin glucuronyltransferase 3
, chondroitin synthase 2