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human D4ST-1 (show CHST14 Proteins), C4ST-1 (show CHST11 Proteins), and S4ST-2 have differential roles in dermatan sulfate biosynthesis
chondroitin 4-O-sulfotransferase-2 efficiently transferred sulfate from 3'-phosphoadenosine 5'-phosphosulfate (show GAL3ST1 Proteins) to position 4 of non-reducing terminal GalNAc-linkage residues forming chondroitin sulfate.
The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage, and is distributed on the surfaces of many cells and extracellular matrices. Alternatively spliced transcript variants differing only in their 5' UTRs have been found for this gene.
carbohydrate sulfotransferase 12
, chondroitin 4-O-sulfotransferase 2
, chondroitin 4-sulfotransferase 2
, sulfotransferase Hlo