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blockade CHST15 represses colonic fibrosis
The direct action of CHST15 on the proliferation.
Findings indicate that GalNAc4S-6ST mRNA expressed by astrocytic tumor cells is associated with poor patient prognosis.
GalNAc4S-6ST play a crucial role in pulmonary metastasis at least through the increased adhesion and the invasive capacity of LLC cells and also provides insights into future drug targets for anticancer treatment.
In GalNacS-6ST knockout mice chondroitin/dermatan sulfate containing N-acetylgalactosamine 4,6-bissulfate residues disappear completely.
GalNAc4S-6ST has a role during early mouse development
analysis of the three CS sulfotransferases in the developing neocortex: uronyl 2-O-sulfotransferase (UST), N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase (4,6-ST) and dermatan 4-O-sulfotransferase-1 (D4-ST)
expression of the Serglycincore protein, chondroitin 4 (show CHST11 ELISA Kits)-sulfotransferase (C4ST)-1 (show CHST11 ELISA Kits), and GalNAc(4S)-6-O-sulfotransferase (GalNAc4S6ST) are closely linked to mast cell maturation
Chondroitin sulfate (CS) is a glycosaminoglycan which is an important structural component of the extracellular matrix and which links to proteins to form proteoglycans. Chondroitin sulfate E (CS-E) is an isomer of chondroitin sulfate in which the C-4 and C-6 hydroxyl groups are sulfated. This gene encodes a type II transmembrane glycoprotein that acts as a sulfotransferase to transfer sulfate to the C-6 hydroxal group of chondroitin sulfate. This gene has also been identified as being co-expressed with RAG1 in B-cells and as potentially acting as a B-cell surface signaling receptor. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
B cell RAG associated protein
, carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
, carbohydrate sulfotransferase 15-like
, N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase
, B cell RAG associated protein (GALNAC4S-6ST)
, B-cell RAG-associated gene protein
, carbohydrate sulfotransferase 15
, GalNAc 4-sulfate 6-O-sulfotransferase