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the copy number variations of CHST9 have been shown to associate with hematologic malignancies
The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Sulfate groups on carbohydrates confer highly specific functions to glycoproteins, glycolipids, and proteoglycans, and are critical for cell-cell interaction, signal transduction, and embryonic development. Alternatively spliced transcript variants have been described for this gene.
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9
, carbohydrate sulfotransferase 9
, GalNAc-4-sulfotransferase 2
, carbohydrate sulfotransferase 9-like
, N-acetylgalactosamine 4-O-sulfotransferase 2
, galNAc-4-O-sulfotransferase 2
, N-acetylgalactosamine-4-O-sulfotransferase 2