Browse our Chondroitin Sulfate Synthase 1 Proteins (CHSY1)

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Chondroitin Sulfate Synthase 1 Proteins (CHSY1)
On are 5 Chondroitin Sulfate Synthase 1 (CHSY1) Proteins from 2 different suppliers available. Additionally we are shipping Chondroitin Sulfate Synthase 1 Antibodies (35) and many more products for this protein. A total of 41 Chondroitin Sulfate Synthase 1 products are currently listed.
CHSY, ChSy-1, CSS1, mKIAA0990, TPBS
list all proteins Gene Name GeneID UniProt
Rat CHSY1 CHSY1 292999  
CHSY1 22856 Q86X52
CHSY1 269941 Q6ZQ11

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Chondroitin Sulfate Synthase 1 Proteins (CHSY1) by Origin

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Human Chondroitin Sulfate Synthase 1 (CHSY1) interaction partners

  1. CHSY1 overexpression in HCC (show FAM126A Proteins) contributes to the malignant behavior of hepatocellular carcinoma cells via activation of the hedgehog (show SHH Proteins) signaling pathway.

  2. CHSY1 expression is closely associated with malignant potential of soft tissue sarcomas with myxoid substance.

  3. A novel missense mutation (c.1897 G > A) in the CHSY1 gene in two Temtamy preaxial brachydactyly syndrome patients from a consanguineous Pakistani family.

  4. elongation of chondroitin sulfate chains may be tightly regulated by the cooperative expression of chondroitin synthase-1 and chondroitin N-acetylgalactosaminyltransferase-1 in peripheral neurons and peripheral neuropathies

  5. conclude that CHSY1 is a secreted FRINGE enzyme required for adjustment of NOTCH (show NOTCH1 Proteins) signaling throughout human and fish embryogenesis and particularly during limb patterning

  6. unrestricted Bmp2b (show BMP4 Proteins) signaling or loss of Dan activity leads to reduced chsy1 expression and, during epithelial morphogenesis, defects similar to those that occur upon Chsy1 inactivation

  7. chondroitin polymerizing activity requires concomitant expression of a ChPF (show CHPF Proteins) with ChSy; coexpression of the ChPF (show CHPF Proteins) and ChSy yielded markedly augmented glycosyltransferase (show GTDC2 Proteins) activities, whereas simple mixing of the two separately expressed proteins did not.

Mouse (Murine) Chondroitin Sulfate Synthase 1 (CHSY1) interaction partners

  1. Data indicate a phosphorylated tetrasaccharide linkage structure, GlcUAbeta1-3Galbeta1-3Galbeta1-4Xyl(2-O-phosphate), in chondroitin N-acetylgalactosaminyltransferase-1 knockout ChGn (show CSGALNACT1 Proteins)-1(-/-) growth plate cartilage.

  2. The results showed that Chsy1 is an essential regulator of joint patterning and provide a mouse model of human brachydactylies caused by mutations in CHSY1.

Chondroitin Sulfate Synthase 1 (CHSY1) Protein Profile

Protein Summary

This gene encodes a member of the chondroitin N-acetylgalactosaminyltransferase family. These enzymes possess dual glucuronyltransferase and galactosaminyltransferase activity and play critical roles in the biosynthesis of chondroitin sulfate, a glycosaminoglycan involved in many biological processes including cell proliferation and morphogenesis. Decreased expression of this gene may play a role in colorectal cancer, and mutations in this gene are a cause of temtamy preaxial brachydactyly syndrome.

Alternative names and synonyms associated with Chondroitin Sulfate Synthase 1 (CHSY1)

  • chondroitin sulfate synthase 1 (Chsy1)
  • chondroitin sulfate synthase 1 (CHSY1)
  • CHSY protein
  • ChSy-1 protein
  • CSS1 protein
  • mKIAA0990 protein
  • TPBS protein

Protein level used designations for CHSY1

carbohydrate (chondroitin) synthase 1 , N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 1 , N-acetylgalactosaminyltransferase II , carbohydrate synthase 1 , chondroitin glucuronyltransferase 1 , chondroitin glucuronyltransferase II , chondroitin synthase 1 , glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase 1 , N-acetylgalactosaminyltransferase 1 , chSy-1

292999 Rattus norvegicus
22856 Homo sapiens
269941 Mus musculus
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