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RNAi-mediated knockdown of endogenous FUCA1 significantly attenuates p53 (show TP53 ELISA Kits)-dependent, chemotherapy-induced apoptotic death.
whole exome sequencing and array-based comparative genomic hybridization analysis revealed that the patient was compound heterozygous for a single base-pair deletion inherited from his father, and a 3281-base-pair deletion covering exon 3 inherited from his mother. Neither mutation has been reported before so the FUCA1 mutational spectrum is herein expanded.
results show that protein defucosylation mediated by FUCA1 is involved in tumor suppression
FUCA1 downregulation confers inferior survival for triple-negative breast cancer patients by modulating the glycosylation status of the tumor cell surface
We observed significant lower values of GAL (show GAL ELISA Kits), alpha-fucosidase and tendency to decrease of MAN and GLU (show DCTN1 ELISA Kits) concentration in nasal polyps
Serum alpha-L-fucosidase (show Fuca ELISA Kits) levels were significantly elevated in hepatocellular carcinoma.
IL-13 (show IL13 ELISA Kits), IL-4 (show IL4 ELISA Kits) and IL-5 (show IL5 ELISA Kits) have no effect on the expression of FUCA1 and FUCA2 (show FUCA2 ELISA Kits), but its expression is upregulated by IFN-gamma (show IFNG ELISA Kits), a Th1 (show TH1L ELISA Kits) cytokine.
Diminished FUCA1 mRNA levels in tumors, indicate that expression of tissue alpha-L-fucosidase could be regulated at transcriptional level in colorectal cancer.
In the serum of patients with Lyme disease, GAL (show GAL ELISA Kits) activity significantly increased (p = 0.029), and the activity of FUC had a tendency to increase (p = 0.153), compared to the control group.
The purified alpha-L-fucosidase (show Fuca ELISA Kits) from primary hepatocarcinoma (PHC (show SLC25A3 ELISA Kits)) is different in its properties from alpha-L-fucosidase (show Fuca ELISA Kits) in human other organs. The polyclonal antibody prepared in this experiment can be applied to the diagnosis of PHC (show SLC25A3 ELISA Kits).
The protein encoded by this gene is a lysosomal enzyme involved in the degradation of fucose-containing glycoproteins and glycolipids. Mutations in this gene are associated with fucosidosis (FUCA1D), which is an autosomal recessive lysosomal storage disease. A pseudogene of this locus is present on chr 2.
fucosidase, alpha-L-1, tissue
, tissue alpha-L-fucosidase
, fucosidase, alpha-L- 1, tissue
, alpha-L-fucosidase 1
, tissue alpha-L-fucosidase-like
, alpha-L-fucosidase I
, alpha-L-fucoside fucohydrolase 1
, Fucosidase alpha-L-1 tissue
, Fucosidase, alpha-L-1, tissue