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The aim of this study was to compare the levels of electrolytes, inorganic phosphatase, and alkaline phosphatease, acid phosphatase, and beta-glucuronidase.
We produced GUS from a CHO (show COL11A1 ELISA Kits) cell line grown in suspension in a 15 L perfused bioreactor and developed a three step purification procedure that yields approximately 99% pure enzyme with a recovery of more than 40%.
the efficacy of a helper-dependent (HD) canine adenovirus (CAV-2 (show CAV2 ELISA Kits)) vector harboring a human GUSB expression cassette (HD-RIGIE) in the MPS VII (show TH ELISA Kits) dog brain was tested
This assessment demonstrated that although butyrate dramatically increased beta-glucuronidase production in bioreactors, it adversely impacted the mannose-6-phosphorylation of this lysosomal storage diseasestherapeutic enzyme
expression of CES2, UGTA1A1, and GUSB varies in colorectal pathology tissues and that the expression of CES2 is somewhat related to tumor staging.
GUSB and ATP2B4 (show ATP2B4 ELISA Kits) have been validated as a reliable gene combination for Cystic Fibrosis Transmembrane Conductance Regulator (show CFTR ELISA Kits) gene qPCR data normalization.
Liver disease affects the expression of common HKGs; beta-glucuronidase and splicing factor arginine/serine-rich 4 (show SRSF4 ELISA Kits) are the most stable HKGs for studies of gene expression in HCV-infected human liver.
beta-glucuronidase mutations are associated with mucopolysaccharidosis type VII (show TH ELISA Kits)
Recombinant adeno (show ADORA2A ELISA Kits)-associated virus encoding human GUSB injected into the vitreous humor of young adult MPS VII (show TH ELISA Kits) mice increased GUSB activity and reduced lysosomal distension in regions of the thalamus and tectum
beta glucuronidase present in the synovial fluid of rheumatoid arthritis patients, may contribute to the depletion of glycosaminoglycans from cartilage allowing invasion of synovial cells.
Over-expression of beta-glucuronidase was related to the degree of cancer differentiation, but not to lymph node metastasis.
Administration of murine beta-glucuronidase to MPS VII (show TH ELISA Kits) mice at 4months of age, when bone disease was fully manifested, using lentiviral gene delivery resulted in a doubling of osteoclast numbers and a significant increase in attachment capacity (68% versus 29.4% in untreated MPS VII (show TH ELISA Kits) animals). Bone mineral volume rapidly decreased by 39% after gene therapy and fell within the normal range by 6months of age
beta-Glucuronidase, a Regulator of Lyme Arthritis Severity, Modulates Lysosomal Trafficking and MMP-9 (show MMP9 ELISA Kits) Secretion in Response to Inflammatory Stimuli
GUSB modulates arthritis pathogenesis by preventing accumulation of proinflammatory glycosaminoglycans within inflamed joint tissue.
The Gus plays a role in liver retinoid metabolism.
Missense mutations and models of murine mucopolysaccharidosis type VII (show TH ELISA Kits) produced by targeted mutagenesis
data indicate the expression of beta-glucuronidase coordinated with testosterone level in male CBA mice but not C57BL/6 mice
Lysosome storage in the mucopoysaccharidosis type VII (show TH ELISA Kits) brain was corrected by injection of an HSV-1 genetic vector and expression of Gusb was assayed. genetic vector
AnxA6 (show ANXA6 ELISA Kits) is a novel receptor that mediates the endocytosis of bovine beta-glucuronidase.
This gene encodes a hydrolase that degrades glycosaminoglycans, including heparan sulfate, dermatan sulfate, and chondroitin-4,6-sulfate. The enzyme forms a homotetramer that is localized to the lysosome. Mutations in this gene result in mucopolysaccharidosis type VII. There are many pseudogenes of this locus in the human genome.
, Beta-glucuronidase (gusB)
, adipose storage deficiency