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Cow (Bovine) Polyclonal GPC4 Primary Antibody for WB - ABIN2789855
Walshe, Harkin: Serial explant culture provides novel insights into the potential location and phenotype of corneal endothelial progenitor cells. in Experimental eye research 2014
According to behavioral studies, downregulation of Gpc4 by Gpc4 siRNA decreased spontaneous seizure frequency, while upregulation of Gpc4 by recombinant Gpc4 overexpression led to a converse result. These findings support the hypothesis that increased expression of Gpc4 in the brain is associated with epileptic seizures.
Data suggest gender difference in circulating GPC4 levels in nonalcoholic fatty liver disease; GPC4 levels in women appear to correlate with cardiometabolic risk factors (adiposity/body fat distribution, insulin (show INS Antibodies) resistance, and arterial stiffness).
new function of miR (show MLXIP Antibodies)-125a by targeting gene glypican-4 in cell growth process
Findings establish that Gpc4 acts at the interface of extrinsic and intrinsic signal regulation to fine tune stem cell fate.
Glypican 4 induces release of neuronal pentraxin 1 (show NPX1 Antibodies) from presynaptic terminals.
data identify glypicans as a family of novel astrocyte-derived molecules that are necessary and sufficient to promote glutamate (show GRIN1 Antibodies) receptor clustering and receptivity and to induce the formation of postsynaptically functioning CNS synapses
complex pattern of glypican-4 mRNA localization at embryonic days 7-10.5, including sites in the anterior forebrain neuroepithelium, branchial arches, optic and otic vesicles, limb buds and somites
the chaperon Wls (show WLS Antibodies) and its ligands Wnt9a (show WNT9A Antibodies) and Wnt5b (show WNT5B Antibodies) are expressed in the ectoderm, whereas juxtaposed chondrocytes express Frzb (show FRZB Antibodies) and Gpc4.
A mutation in glypican4 leads to severe lateral line primordium migration defects. Glypican4 regulates the feedback loop between Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies)/Fgf signaling in the primordium redundantly with other HSPGs. A mutation in glypican4 affects primordium migration non cell-autonomously
disruption of wls (show WLS Antibodies) resulted in a significant loss of craniofacial bone, whereas lack of gpc4, wnt5b (show WNT5B Antibodies) and wnt9a (show WNT9A Antibodies) resulted in severely delayed endochondral ossification.
novel mechanism for Wnt5b (show WNT5B Antibodies) and Gpc4 regulation of chondrocyte behavior that is independent of the core Wnt (show WNT2 Antibodies)/PCP (show PRCP Antibodies) molecules and differs from their collaborative action of controlling cell movements during gastrulation
glypican4 mutants do not have decreased proteolysis of ECM substrates, but instead have increased cell surface cadherin protein expression and increased intercellular adhesion.
These findings implicate Gpc4 in the regulation of zebrafish cartilage and bone morphogenesis.
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The GPC4 gene is adjacent to the 3' end of GPC3 and may also play a role in Simpson-Golabi-Behmel syndrome.
, glypican 4
, dJ900E8.1 (glypican 4)
, glypican proteoglycan 4