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Human Polyclonal GPC6 Primary Antibody for WB - ABIN390354
Veugelers, De Cat, Ceulemans, Bruystens, Coomans, Dürr, Vermeesch, Marynen, David: Glypican-6, a new member of the glypican family of cell surface heparan sulfate proteoglycans. in The Journal of biological chemistry 1999
Show all 2 references for ABIN390354
Human Polyclonal GPC6 Primary Antibody for EIA, WB - ABIN358978
Paine-Saunders, Viviano, Saunders: GPC6, a novel member of the glypican gene family, encodes a product structurally related to GPC4 and is colocalized with GPC5 on human chromosome 13. in Genomics 1999
Show all 2 references for ABIN358978
Human Polyclonal GPC6 Primary Antibody for EIA, IHC (p) - ABIN952557
Lau, Yu, Wong, Fan, Mak, Wong, Lam, Pang, Choy: Allelic imbalance at 13q31 is associated with reduced GPC6 in Chinese with sporadic retinoblastoma. in The British journal of ophthalmology 2010
Show all 2 references for ABIN952557
Thus, GPC6 and TMEM132D may serve as predictors of CD8 (show CD8A Antibodies)+ T-lymphocyte infiltration and as favorable prognostic markers in early stage ovarian cancer with important consequences for diagnosis.
GPC6 promotes invasive migration by inhibition of canonical beta-catenin (show CTNNB1 Antibodies) and Wnt (show WNT2 Antibodies) signalling, and up-regulation of non-canonical Wnt5A (show WNT5A Antibodies) signalling leading to the activation of JNK (show MAPK8 Antibodies) and p38 MAPK (show MAPK14 Antibodies).
a reduction in GPC6 mRNA in retinoblastoma is associated with the non-random allelic loss at 13q31 that could contribute to RB development.
Mutations in the heparan-sulfate proteoglycan glypican 6 impair endochondral ossification and cause recessive omodysplasia
data identify glypicans as a family of novel astrocyte-derived molecules that are necessary and sufficient to promote glutamate (show GRIN1 Antibodies) receptor clustering and receptivity and to induce the formation of postsynaptically functioning CNS synapses
The glypicans comprise a family of glycosylphosphatidylinositol-anchored heparan sulfate proteoglycans, and they have been implicated in the control of cell growth and cell division. The glypican encoded by this gene is a putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases.
, glypican proteoglycan 6