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Human Polyclonal HAS2 Primary Antibody for FACS, IHC (p) - ABIN651874
Simpson, Wilson, Furcht, Spicer, Oegema, McCarthy: Manipulation of hyaluronan synthase expression in prostate adenocarcinoma cells alters pericellular matrix retention and adhesion to bone marrow endothelial cells. in The Journal of biological chemistry 2002
Show all 5 references for ABIN651874
Human Monoclonal HAS2 Primary Antibody for ICC, IHC - ABIN1098124
Okuda, Kobayashi, Xia, Watabe, Pai, Hirota, Xing, Liu, Pandey, Fukuda, Modur, Ghosh, Wilber, Watabe: Hyaluronan synthase HAS2 promotes tumor progression in bone by stimulating the interaction of breast cancer stem-like cells with macrophages and stromal cells. in Cancer research 2012
Show all 2 references for ABIN1098124
identify Npnt (show NPNT Antibodies) as a novel upstream regulator of Bmp4 (show BMP4 Antibodies)-Has2 signaling that plays a crucial role in AV canal differentiation
MiR-23 is both necessary and sufficient for restricting the number of endocardial cells that differentiate into endocardial cushion cells by inhibiting Has2 and extracellular hyaluronic acid production.
data demonstrate that elevated glucose alone induces cardiac defects in zebrafish embryos by altering the expression pattern of tbx5 (show TBX5 Antibodies), tbx20 (show TBX20 Antibodies), and has2 in the hear
Has2 mRNA was expressed in the surrounding mesenchyme from E12.0 to 18.0 in both molar and incisor tooth germs, but disappeared after birth.
the ineffective repair of injured cartilage in Has1 (show HAS1 Antibodies)(-/-) joints can be at least partly explained by the markedly enhanced expression of particular genes in pathways linked to ECM (show MMRN1 Antibodies) turnover, IL-17 (show IL17A Antibodies)/IL-6 (show IL6 Antibodies) cytokine signaling, and apoptosis.
these results highlight the role of nSMase2 (show SMPD3 Antibodies) in apoptosis evoked by nutrient starvation that could contribute to the delayed apoptosis of hypertrophic chondrocytes in the growth plate, and emphasize the antiapoptotic properties of HAS2
mir (show MLXIP Antibodies)-23a-3p causes cellular senescence by targeting hyaluronan synthase 2: possible implication for skin aging.
Has2 expression and hyaluronan produced at the tips of epithelial cells play a critical role in driving tubulogenesis and branching in vitro.
Hyaluronan synthase 2 has a role in protecting skin fibroblasts against apoptosis induced by environmental stress
Stimulation with LPS (show TLR4 Antibodies) caused rapid increases in versican (show Vcan Antibodies) mRNA and protein, a rapid increase in Has1 (show HAS1 Antibodies) mRNA, and concomitant inhibition of hyaluronidases 1 and 2, the major hyaluronan degrading enzymes
This study demonistrated that Has2 expression in adult mouse subventricular zone and rostral migratory stream and in ischemic cortex.
This study identifies Has2 as a novel downstream target of Shh (show SHH Antibodies) signaling required for joint patterning and chondrogenesis.
HAS2 was significantly upregulated at the level of gene expression during muscle hypertrophy.
HAS2 and HAS3 (show HAS3 Antibodies) were the only hyaluronan synthases detected, the expression of which was almost similar in NPs (show NPS Antibodies) and NM.
HAS2 has been proposed to be a target for therapeutic intervention in cancer. Our findings suggested a possible antagonistic role of androgen receptor (AR (show AR Antibodies)) pathway on HAS2 function.
HAS-2 gene silencing may inhibit proliferation and promote apoptosis in the MCF-7 human breast cancer cell line.
Our study establishes HAS2-mediated HA synthesis as a driver of growth of bladder cancer with low AGL (show AGL Antibodies) and provides preclinical rationale for personalized targeting of HAS2/HA signaling in patients with low amylo-alpha-1-6-glucosidase-4-alpha-glucanotransferase (show AGL Antibodies) -expressing tumors.
HAS2-HA system influences the biological characteristics of human breast cancer cells
Regulation of Hyaluronan (HA) Metabolism Mediated by HYBID (Hyaluronan-binding Protein Involved in HA Depolymerization, KIAA1199 (show KIAA1199 Antibodies)) and HA Synthases in Growth Factor-stimulated Fibroblasts.
Our study identified HAS2 as a novel candidate gene for susceptibility to adult asthma.
In contrast to other carcinoma subtypes, HAS2 expression was observed in up to 72.7% of metaplastic carcinomas of breast, a carcinoma subtype related to the epithelial-mesenchymal transition.
transcriptional regulation of the HAS and HAS2-antisense RNA 1 genes, was analyzed.
review of the roles of HAS2 and CD44 (show CD44 Antibodies) in breast tumorigenesis [review]
In the absence of XHas2, early myoblasts underwent apoptosis, failing to complete their muscle differentiation programme. XHas2 activity is also required for migration of hypaxial muscle cells and trunk neural crest cells (NCC (show SLC12A3 Antibodies)).
Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and human and murine hyaluronan synthase 1.
hyaluronan synthase 2
, hyaluronic acid synthase 2
, HA synthase 2
, hyaluronan synthase homolog
, hyaluronate synthase 2