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Genetic variants of HS3ST3A1 and HS3ST3B1 (show HS3ST3B1 Proteins) are associated with Plasmodium falciparum parasitaemia.
Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity. The sulfotransferase domain of this enzyme is highly similar to the same domain of heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1, and these two enzymes sulfate an identical disaccharide. This gene is widely expressed, with the most abundant expression in liver and placenta.
, heparan sulfate 3-O-sulfotransferase 3A1
, heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1
, heparan sulfate glucosamine 3-O-sulfotransferase 3A1
, heparin-glucosamine 3-O-sulfotransferase