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HAS2 (show HAS2 Proteins) and HAS3 (show HAS3 Proteins) were the only hyaluronan synthases detected, the expression of which was almost similar in NPs (show NPS Proteins) and NM.
The receiver-operating characteristic curve analyses demonstrated that each one had good sensitivity and specificity for distinguishing BC patients from non-BC ones (HYAL1, miR (show MLXIP Proteins)-210, miR (show MLXIP Proteins)-96, lncRNA-UCA1, 91.5 and ).
Study showed that reduced HYAL1 expression was associated with endometrial carcinoma aggressiveness, which further supported the role of hyaluronan degradation in cancer progression.
Results demonstrated that HYAL1 was C-mannosylated and suggest the possible role of C-mannosylation for secretion and enzymatic activity of HYAL1.
Hyaluronan (HA) interacting proteins RHAMM (show HMMR Proteins) and hyaluronidase (show HAase Proteins) impact prostate cancer cell behavior and invadopodia formation in 3D HA-based hydrogels.
In contrast to the previously described MPS IX patient, our three patients display a phenotype limited to the joints, suggesting that this is the primary manifestation of HYAL1 deficiency.
Upregulation of HYAL1 expression in breast cancer promoted tumor cell proliferation, migration, invasion and angiogenesis.
This is the first report showing high HYAL-1 levels in epithelial ovarian cancer.
HYAL-1 and HAS1 (show HAS1 Proteins) expression predicted BCa (show BLNK Proteins) metastasis, and HYAL-1 expression also predicted disease-specific survival.
HYAL1 overexpression is correlated with the malignant behavior of breast cancer.
results are consistent with a role for hyaluronan and hyaluronoglucosaminidase 1 and 2 in the development of the microscopic folds of the pig placenta during gestation
the porcine hyaluronidase (show HAase Proteins) cluster consisting of genes HYAL1, HYAL2 (show HYAL2 Proteins) and HYAL3 (show HYAL3 Proteins) was characterized
This study focuses on the investigation of the digestibility of glycosaminoglycans with different degrees of sulfation by bovine testicular hyaluronidase (show HAase Proteins).
HYAL1 is necessary for the breakdown of intracellular HA in the cortex, whereas HYAL2 (show HYAL2 Proteins) is essential for the degradation of extracellular HA in all kidney regions
The activity of the processed form of Hyal-1 was largely underestimated.
The knockdown of Hyal-1 results in an 80% decrease of total acid hyaluronidase (show HAase Proteins) activity in the mouse liver, confirming that Hyal-1 is a key actor of hyaluronic acid catabolism in this organ.
Chondroitin sulfate is a crucial determinant for skeletal muscle development/regeneration and improvement of muscular dystrophies through HYAL1
both HYAL1 and beta-hexosaminidase (show HEXA Proteins) cleave chondroitin sulfate, but it is a preferred substrate for beta-hexosaminidase (show HEXA Proteins). These studies provide in vivo evidence to support and extend existing knowledge of GAG breakdown.
Data show that Hyal-1, but not Hyal-3 (show HYAL3 Proteins),is an ovarian regulator factor for follicle development, and show an interrelationship between this enzyme and the follistatin (show FST Proteins)/activin/Smad3 (show SMAD3 Proteins) pathway.
Endothelial surface layer degradation by chronic hyaluronidase (show HAase Proteins) infusion induces proteinuria in apolipoprotein E (show APOE Proteins)-deficient mice
Characterization of the murine hyaluronidase (show HAase Proteins) gene region reveals complex organization and cotranscription of Hyal1 with downstream genes, Fus2 (show NAT6 Proteins) and Hyal3 (show HYAL3 Proteins).
Hyal1 null mice had evidence of osteoarthritis with a loss of proteoglycans at early ages.
Hyaluronidase (show HAase Proteins) induces ovarian granulosa cell apoptosis and is involved in follicular atresia.
This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene.
, lung carcinoma protein 1
, plasma hyaluronidase
, tumor suppressor LUCA-1
, hyaluronidase 1