Browse our Inter-alpha Trypsin Inhibitor, Heavy Chain 1 Proteins (ITIH1)

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Inter-alpha Trypsin Inhibitor, Heavy Chain 1 Proteins (ITIH1)
On www.antibodies-online.com are 7 Inter-alpha Trypsin Inhibitor, Heavy Chain 1 (ITIH1) Proteins from 4 different suppliers available. Additionally we are shipping Inter-alpha Trypsin Inhibitor, Heavy Chain 1 Antibodies (76) and Inter-alpha Trypsin Inhibitor, Heavy Chain 1 Kits (14) and many more products for this protein. A total of 106 Inter-alpha Trypsin Inhibitor, Heavy Chain 1 products are currently listed.
Synonyms:
H1P, IATIH, IGHEP1, Intin1, ITI-HC1, ITIH, Itih-1, SHAP
list all proteins Gene Name GeneID UniProt
ITIH1 16424 Q61702
ITIH1 306251  
ITIH1 3697 P19827

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Inter-alpha Trypsin Inhibitor, Heavy Chain 1 Proteins (ITIH1) by Origin

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Top referenced Inter-alpha Trypsin Inhibitor, Heavy Chain 1 Proteins

  1. Human ITIH1 Protein expressed in Wheat germ - ABIN1308229 : Gu, Duce, Valova, Wong, Bush, Petrou, Wiley: P2X7 receptor-mediated scavenger activity of mononuclear phagocytes toward non-opsonized particles and apoptotic cells is inhibited by serum glycoproteins but remains active in cerebrospinal fluid. in The Journal of biological chemistry 2012 (PubMed)

More Proteins for Inter-alpha Trypsin Inhibitor, Heavy Chain 1 Interaction Partners

Mouse (Murine) Inter-alpha Trypsin Inhibitor, Heavy Chain 1 (ITIH1) interaction partners

  1. PTX3 directly interacts with inter-alpha-trypsin inhibitor and has a role in hyaluronan organization and cumulus oophorus expansion

  2. In a sepsis model inter-alpha-trypsin inhibitor inhibits complement activation through the classical and alternative pathways, inhibits complement-dependent phagocytosis in vitro, and reduces complement-dependent lung injury in vivo.

Human Inter-alpha Trypsin Inhibitor, Heavy Chain 1 (ITIH1) interaction partners

  1. Furthermore, thrombin treatment of the inflammatory matrix leads to dissolution of HC-HA cable structures and abolishes leukocyte adhesion. These data establish a novel mechanism whereby thrombin cleavage of HC1 regulates the adhesive properties of an inflammatory HA matrix.

  2. Data suggest that Mg2 (show MUC7 Proteins)+ or Mn2+ (but not Ca2 (show CA2 Proteins)+) induce a conformational change in inter-alpha-inhibitor (ITIH1 and ITIH2 (show ITIH2 Proteins)) and a bikunin (show AMBP Proteins)/chondroitin sulfate-dependent increase in thermodynamic stability; bikunin (show AMBP Proteins) binds adjacent to the two heavy chains.

  3. The results of this study revealed that the shared genetic risk factors of both schizophrenia and major depressive disorder exist in ITIH family genes in the Han Chinese population.

  4. Data indicate that TSG-6 (show TNFAIP6 Proteins)-mediated cross-linking of hyaluronan (HA) films is impaired in the presence of inter-alpha-inhibitor (IalphaI) and that this effect suppresses the TSG-6 (show TNFAIP6 Proteins)-mediated enhancement of HA binding to CD44 (show CD44 Proteins)-positive cells.

  5. Human inter-alpha-inhibitor is a substrate for factor XIIIa (show F13A1 Proteins) and tissue transglutaminase (show TGM2 Proteins).

  6. PTX3 directly interacts with inter-alpha-trypsin inhibitor and has a role in hyaluronan organization and cumulus oophorus expansion

  7. The first systematic analysis on the differential expression of ITIH genes in human cancer, showing frequent downregulation that may be associated with initiation and/or progression of these malignancies.

Inter-alpha Trypsin Inhibitor, Heavy Chain 1 (ITIH1) Protein Profile

Protein Summary

The protein encoded by this gene is the heavy chain of a serine protease inhibitor that may serve to carry hyaluronan in plasma. This gene is part of a cluster of similar genes on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with Inter-alpha Trypsin Inhibitor, Heavy Chain 1 (ITIH1)

  • inter-alpha trypsin inhibitor, heavy chain 1 (Itih1)
  • inter-alpha-trypsin inhibitor heavy chain 1 (ITIH1)
  • H1P protein
  • IATIH protein
  • IGHEP1 protein
  • Intin1 protein
  • ITI-HC1 protein
  • ITIH protein
  • Itih-1 protein
  • SHAP protein

Protein level used designations for ITIH1

ITI heavy chain H1 , ITI-HC1 , inter-alpha (globulin) inhibitor, H1 polypeptide , inter-alpha-inhibitor heavy chain 1 , inter-alpha-trypsin inhibitor heavy chain H1 , inter-alpha (globulin) inhibitor H1 , inter-alpha-trypsin inhibitor complex component III , serum-derived hyaluronan-associated protein , inter-alpha-trypsin inhibitor heavy-chain H1

GENE ID SPECIES
16424 Mus musculus
306251 Rattus norvegicus
3697 Homo sapiens
508356 Bos taurus
396963 Sus scrofa
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