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Human LUM ELISA Kit for Sandwich ELISA - ABIN367235
Gu, Cheng, Yao, Yin, Tong, Rao, Yen, Ku, Rao: Quantitative proteomics analysis by isobaric tags for relative and absolute quantitation identified Lumican as a potential marker for acute aortic dissection. in Journal of biomedicine & biotechnology 2012
Show all 2 Pubmed References
Human LUM ELISA Kit for Sandwich ELISA - ABIN414729
Lee, Park, Norwitz, Kim, Park, Jun, Syn: Identification and characterization of proteins in amniotic fluid that are differentially expressed before and after antenatal corticosteroid administration. in American journal of obstetrics and gynecology 2010
Show all 2 Pubmed References
temporal expression of LUM mRNA during dermal wound repair in the horse
the role of lumican in the development of axial myopia
Cancer-associated fibroblast-derived Lumican contributes to tumorigenesis and metastasis of gastric cancer
Lumican and versican (show Vcan ELISA Kits) protein expression are associated with colorectal adenoma-to-carcinoma progression
Lumican is downregulated in the process of scar formation and alleviates hypertrophic scarring by suppressing integrin-FAK (show PTK2 ELISA Kits) signaling.
ectopic mutant lumican (L199P) may induce enlargement of axial lengths and abnormal structures and distributions of collagen fibrils in mouse sclera
Quantitative polymerase chain reaction for messenger RNA expression from tissue specimens revealed significantly higher expression of Biglycan (show BGN ELISA Kits) (p = 0.0008) and Lumican (p = 0.01) and lower expression of Decorin (show DCN ELISA Kits) (p < 0.0001) in urothelial carcinoma of bladder
analysis of decorin (show DCN ELISA Kits) and lumican expression in fibroblasts correlated with palmoplantar collagen bundle size
fibroblasts stimulated with the fibrocyte-secreted inflammatory signal tumor necrosis factor-alpha (show TNF ELISA Kits) secrete the small leucine-rich proteoglycan (show Vcan ELISA Kits) lumican.
This meta-analysis suggests that LUM polymorphisms are associated with the risk of high myopia.
The results suggest that regions within LUM is associated with ACL (show ACLY ELISA Kits) injury susceptibility and that genetic sequence variability within genes encoding proteoglycans may potentially modulate the ligament fibril properties.
meta-analysis, including 1,545 subjects from 5 studies, indicated that Chinese lumican rs3759223 C allele carriers had a decreased risk of high myopia in comparison to T allele carriers
this study shows that Lum negatively regulates encephalitic TH17 cells, implicating a potential therapeutic pathway in TH17 cell mediated autoimmune and inflammatory diseases
alternations of lumican might be implicated in the pathogenesis of cardiac fibrosis
LUM may coordinate multiple factors of collagen assembly in the murine heart.
Lumican and biglycan (show BGN ELISA Kits) influence corneal keratocyte lamellipodia organization and are critical in the regulation of stromal collagen fibrillogenesis.
Alterations in glycosylated lumican core protein might be implicated in myocardial remodeling and reverse remodeling, with a potential important role for CS/DS GAG chain-synthesizing enzymes.
pro-inflammatory cytokine TNF-alpha (show TNF ELISA Kits) was comparably low 24 hours after infection, but significantly higher in the Lum(-/-) compared to Lum(+/-) infected corneas by 2-5 days after infection
lumican present in the reactive stroma surrounding prostate primary tumors plays a restrictive role on cancer progression
To investigate the functional role of lumican in hepatic fibrosis, lumican null (Null) and wild-type (WT) littermates were administered carbon tetrachloride intra-peritoneally. Hepatic fibrosis was greatly reduced in null animals.
lumican has a major protective role in gram-negative bacterial infections, a novel function for small leucine-rich repeat proteoglycans.
These results suggest that lumican plays a pivotal role in the development of tissue engineered cartilage and that regulation of this protein may be important for the production of high-quality implants.
FGF-2 (show FGF2 ELISA Kits)- and TGF-beta1 (show TGFB1 ELISA Kits)-activation of JNK (show MAPK8 ELISA Kits) signaling pathway may be partly responsible for the downregulation of keratocan (show KERA ELISA Kits) and lumican expression in activated corneal keratocytes observed during corneal stromal wound healing.
This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair.
, Keratan sulfate proteoglycan lumican
, KSPG lumican
, keratan sulfate proteoglycan lumican
, lumican proteoglycan
, corneal keratan sulfate proteoglycan 37B core protein
, keratan sulfate proteoglycan