Browse our N-Acetylglucosaminidase, alpha Proteins (NAGLU)

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N-Acetylglucosaminidase, alpha Proteins (NAGLU)
On www.antibodies-online.com are 6 N-Acetylglucosaminidase, alpha (NAGLU) Proteins from 3 different suppliers available. Additionally we are shipping N-Acetylglucosaminidase, alpha Antibodies (22) and N-Acetylglucosaminidase, alpha Kits (13) and many more products for this protein. A total of 42 N-Acetylglucosaminidase, alpha products are currently listed.
Synonyms:
MPS-IIIB, MPS3B, NAG, UFHSD
list all proteins Gene Name GeneID UniProt
NAGLU 27419  
NAGLU 4669 P54802
NAGLU    

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Mouse (Murine) N-Acetylglucosaminidase, alpha (NAGLU) interaction partners

  1. In the 1-h test, MPS IIIB mice were hyperactive, with increased rapid exploratory behaviour and reduced immobility time.

  2. Disruption of the Naglu gene responsible for heparan sulfate degradation results in substantial changes in expression of genes related to neural cell growth and function.

  3. Our results demonstrate the advantages of intravenously administering hUCB cells into a mouse model of Sanfilippo Syndrome type B, the advantages probably a result of Naglu delivery to enzyme-deficient organs.

Human N-Acetylglucosaminidase, alpha (NAGLU) interaction partners

  1. Mutation in NAGLU gene is associated with atypical mucopolysaccharidosis IIIB.

  2. in the current meta-analysis, based on ten prospective studies involving 29366 participants, we evaluated the role of urinary tubular injury markers (NGAL, KIM-1 and NAG) in predicting clinical outcomes including CKD stage 3, end stage renal disease and mortality.

  3. Mutations in NAGLU gene is associated with idiopathic progressive cognitive decline.

  4. Plasma NAG correlates with gastrointestinal cancer outcomes.

  5. study reports that carriers from two families of a severe pathogenic mutation in NAGLU develop a late dominant painful axonal sensory neuropathy.

  6. A modified recombinant NAGLU fused to the receptor-binding motif of insulin-like growth factor (IGF)-II enhances its ability to enter cells using the mannose 6-phosphate receptor, which is the receptor for IGF-II at a different binding site.

  7. The research may enrich the mutation spectrum of the NAGLU gene in the Chinese population and help us further in understanding the pathogenesis of MPS IIIB.

  8. Urinary NAG/Cr may be a useful surrogate marker for renal function in ADPKD patients.

  9. This study suggests a possible role of NAGLU in susceptibility to PD while extending evidence for alpha-synuclein aggregation in the brain in lysosomal storage disorders.

  10. We have identified an 1146 bp intragenic deletion of the NAGLU gene within consanguineous parents having two children affected with Sanfilippo syndrome type B.

N-Acetylglucosaminidase, alpha (NAGLU) Protein Profile

Protein Summary

This gene encodes an enzyme that degrades heparan sulfate by hydrolysis of terminal N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides. Defects in this gene are the cause of mucopolysaccharidosis type IIIB (MPS-IIIB), also known as Sanfilippo syndrome B. This disease is characterized by the lysosomal accumulation and urinary excretion of heparan sulfate.

Alternative names and synonyms associated with N-Acetylglucosaminidase, alpha (NAGLU)

  • N-acetylglucosaminidase, alpha (naglu)
  • N-acetylglucosaminidase, alpha (NAGLU)
  • alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB) (Naglu)
  • MPS-IIIB protein
  • MPS3B protein
  • NAG protein
  • UFHSD protein

Protein level used designations for NAGLU

N-acetylglucosaminidase, alpha , alpha-N-acetylglucosaminidase , N-acetylglucosaminidase, alpha- , alpha-N-acetylglucosaminidase-like , N-acetylglucosaminidase, alpha- (Sanfilippo disease IIIB) , N-acetyl-glucosaminidase , alpha-N-acetylglucosaminidase, lysosomal , N-acetyl-alpha-glucosaminidase

GENE ID SPECIES
560126 Danio rerio
100344181 Oryctolagus cuniculus
100479493 Ailuropoda melanoleuca
100489327 Xenopus (Silurana) tropicalis
468265 Pan troglodytes
490965 Canis lupus familiaris
707186 Macaca mulatta
27419 Mus musculus
4669 Homo sapiens
100519685 Sus scrofa
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