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NCAN rs2228603 is not a risk factor for the incidence of NAFLD (show TSC2 ELISA Kits) in Chinese population. The dual and opposite role of T variant in protecting liver with a higher level of HDL (show HSD11B1 ELISA Kits) was found.
This study aims to analyze the influences of single-nucleotide polymorphism in the NCAN-CILP2 (show Cilp2 ELISA Kits) region on non-alcoholic fatty liver disease and plasma lipid levels in the Asian and Pacific ethnic groups.
NCAN genotype is associated with limbic gray matter alterations in healthy and subjects with major depression in brain areas implicated in emotion perception and regulation
current data demonstrate that common genetic variation in NCAN influences both neural processing and cognitive performance in healthy subjects.
The frequency of the NCAN rs2228603 T allele was significantly increased in patients with HCC (show FAM126A ELISA Kits) due to ALD (show ABCD1 ELISA Kits) (15.1%) compared to alcoholic cirrhosis without HCC (show FAM126A ELISA Kits) (9.3%), alcoholic controls (7.2%), healthy controls (7.9%), and HCV associated HCC (show FAM126A ELISA Kits) (9.1%).
NCAN risk variant is associated with cortical folding and thickness in bipolar disorder and schizophrenia.
Conditional analysis shows that a neighbouring gene, TM6SF2, not NCAN, is responsible for the Chr 19 GWAS locus previously associated with fibrosing non-alcoholic fatty liver disease (NAFLD (show TSC2 ELISA Kits)).
NCAN rs2228603[T] is a risk factor for liver inflammation and fibrosis, suggesting that this locus is responsible for progression from steatosis to steatohepatitis.
no genetic association between risk allele A for NCAN locus rs1064395 and schizophrenia.
In the combined patient sample, the NCAN risk allele was significantly associated with the "mania" factor, in particular the subdimension "overactivity.
This study provided evidence that the neurocan modulates synaptogenesis and long-term synapse stability. The mutant neurons display reduced frequencies of mEPSCs and mIPSCs.
Traumatic brain injury results in an increase in the chondroitin glycosaminoglycans (CSPGs) neurocan and NG2 (show Vcan ELISA Kits) expression in a tight band surrounding the injury core.
Ncan -/- mice showed behavioral abnormalities that were strikingly similar to those of the human mania phenotype.
neurocan contributes to the molecular heterogeneity of the perinodal matrix, and its nodal expression is dependent on Bral1 (show HAPLN2 ELISA Kits).
this shows a heterophilic molecular interaction between cell adhesion molecular L1 and neurocan is involved in determining the thalamocortical pathway within the neocortical anlage
PTPsigma (show PTPRS ELISA Kits) binds with high affinity to neural chondroitin sulfate proteoglycans(CPSGs); binding involves chondroitin sulfate chains & a specific site on 1st immunoglobulin-like domain of PTPsigma (show PTPRS ELISA Kits); results indicate PTPsigma (show PTPRS ELISA Kits) can act as a receptor for CSPGs
Neurocan is a chondroitin sulfate proteoglycan thought to be involved in the modulation of cell adhesion and migration.
chondroitin sulfate proteoglycan 3 (neurocan)
, 245 kDa early postnatal core glycoprotein
, chondroitin sulfate proteoglycan 3
, neurocan core protein
, neurocan proteoglycan
, TGFbeta-induced transcript, brain
, chondroitin sulfate proteoglycan 3, related sequence