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OGN plays a critical role in negatively regulating ischaemia-induced angiogenesis by inhibiting VEGF (show VEGFA Proteins)-VEGFR2 (show KDR Proteins) signalling and thereby attenuating endothelial cells tube formation, proliferation, and migration.
The current study discovered a novel 72-kDa chondroitin sulfate-OGN that is specific for innate immune cells. This variant is able to bind and activate TLR4 (show TLR4 Proteins).
mimecan is a satiety hormone in adipose tissue, and that mimecan inhibits food intake independently of leptin (show LEP Proteins) signaling by inducing IL-1beta (show IL1B Proteins) and IL-6 (show IL6 Proteins) expression in the hypothalamus.
Increased plasma mimecan levels are independently associated with increased arterial stiffness in hypertensive patients.
OIF may be an indicator of the earlier-stage diabetic nephropathy in subjects with type 2 diabetes mellitus
OGN might play a role in the development of Ovarian Cancer, and may be a therapeutic target in OC.
Osteomodulin (show OMD Proteins), osteoglycin, and asporin (show ASPN Proteins) appear to be distinctly regulated in osteoarthritis labrum compared to OA cartilage.
The lack of the proteogl (show Vcan Proteins)ycan OGN does not affect the progression of atherosclerosis in mice. Possible causes for the absence of phenotype in the Apoe/Ogn double mutants are discussed.
Circulating OGN and NGAL (show LCN2 Proteins)/MMP9 (show MMP9 Proteins) complex are promising biomarkers that are expressed in vulnerable atherosclerotic plaques and may have incremental value for prediction of MACE within 1 year after coronary angiography.
We found that IGF-2 and IGFBP2 synergistically increased neurite outgrowth via enhanced early signaling through the IGF type 1 receptor.
lack of the proteoglycan (show Vcan Proteins) OGN does not affect the progression of atherosclerosis in mice
The expression of osteoglycin decreased in the medial, basolateral, and central amygdala regions after chronic immobilization stress in mice.
Osteoglycin may be a crucial humoral bone anabolic factor that is produced by muscle tissues.
The temporal-spatial specific pattern and unique co-localization of Dspp (show DSPP Proteins), Mepe, Mimecan and Versican (show Vcan Proteins) suggest they play complementary roles during odontogenesis.
even though there are 3-5 glucocorticoid response elements in the mimecan promoter, glucocorticoid may regulate mimecan transcription indirectly through the synthesis of intermediate proteins
Mimecan in pituitary corticotroph cells may regulate adrenocorticotrophic hormone secretion and the hypothalamo-pituitary-adrenal axis
High expression of osteoglycin decreases the gelatinase activity of hepatocarcinoma Hca-F cells cultured with extract of lymph node.
From our study we conclude that downregulation of osteoglycin is a fundamental requirement for proper arteriogenesis
This gene encodes a protein which induces ectopic bone formation in conjunction with transforming growth factor beta. This protein is a small proteoglycan which contains tandem leucine-rich repeats (LRR). Alternatively spliced transcript variants that encode the same protein have been found for this gene.
, corneal keratan sulfate proteoglycan
, mimecan proteoglycan
, osteoinductive factor
, osteoglycin (osteoinductive factor)
, osteoglycin (osteoinductive factor, mimecan)
, osteoglycin preproprotein