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Human SLC26A1 resembles SLC26 paralogs in its inhibition.
Mutations in SLC26A1 gene is associated with Nephrolithiasis.
Screened the SLC26A1 gene in a cohort of 13 individuals with recurrent calcium oxalate urolithiasis, which is the commonest type. DNA sequence analyses showed missense mutations in seven patients.
SLC26A1 protein,point mutation is highly responsible for the hearing loss of newborns.
The oxalate precursor glyoxylate was identified as a substrate of sat-1 (show SAT1 ELISA Kits). Upregulated expression of sat-1 (show SAT1 ELISA Kits) mRNA and of sat-1 (show SAT1 ELISA Kits) protein indicates that glyoxylate may be responsible for the elevated oxalate release from hepatocytes observed in hyperoxaluria.
Characterization of the SAT1 (show SAT1 ELISA Kits) gene and protein function.
The expression of three messengers coding for SAT-1 (show SAT1 ELISA Kits), SAT-2 (show SLC38A2 ELISA Kits) and GalNAcT (show B4GALNT1 ELISA Kits)-1 in human samples of intestinal cancer and some cell lines (breast cancer and melanomas), was evaluated.
No mutation was found in the coding regions and intron-exon boundaries of the genes for CA II (show CA2 ELISA Kits), CA IV (show CA4 ELISA Kits), CA XIV (show CA14 ELISA Kits), kNCB1, NHE3 (show SLC9A3 ELISA Kits), NHE8 (show SLC9A8 ELISA Kits), NHRF1, NHRF2 and SLC26A6 (show SLC26A6 ELISA Kits) amplified from genomic DNA of family members with pRTA.
Slc26a1, Slc26a6 (show SLC26A6 ELISA Kits) and Slc26a7 (show SLC26A7 ELISA Kits) are novel participants in the extracellular transport of bicarbonate during enamel maturation.
study concludes that a DIDS-sensitive basolateral transporter is involved in mediating oxalate secretion across mouse duodenum, but Sat1 (show SAT1 ELISA Kits) itself is dispensable for this process
Sat1 (show SAT1 ELISA Kits) regulates both oxalate and sulfate homeostasis and may be critical to the development of calcium oxalate urolithiasis and hepatotoxicity.
first characterization of the structure and regulation of the Sat1 (show SAT1 ELISA Kits) gene encoding a SO(4)(2-)/chloride/oxalate anion transporter
This gene is a member of a family of sulfate/anion transporter genes. Family members are well conserved in their genomic (number and size of exons) and protein (aa length among species) structures, but have markedly different tissue expression patterns. This gene is primarily expressed in the liver, pancreas, and brain. Three splice variants that encode different isoforms have been identified.
solute carrier family 26 (sulfate transporter), member 1
, SLC26A1 anion exchanger
, sulfate anion transporter 1
, sulfate anion transporter 1-like
, sulfate anion tranporter AT1
, sulfate/anion transporter SAT-1 protein
, canalicular sulfate transporter
, solute carrier family 26 member 1
, sulfate/carbonate antiporter
, solute carrier family 26, member 1
, sulfate anion transporter-1