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Neurons are a major source of all of the testican (show SPOCK1 ELISA Kits) family members in the normal brain. Abundant distribution of testican 2 may contribute to glioma invasion by inactivating other testican (show SPOCK1 ELISA Kits) family members including N-Tes (show TES ELISA Kits), which all inhibit MT-MMPs.
purification and characterization of a recombinant testican-2 expressed in insect cells; the C1q subcomponent of complement component C1 was identified as a potential interacting partner of testican-2
Both the proteoglycan (show Vcan ELISA Kits) and core protein forms of testican-2 inhibited neurite extension from cultured primary cerebellar neurons and may play regulatory roles in the development of the central nervous system.
This gene encodes a protein which binds with glycosaminoglycans to form part of the extracellular matrix. The protein contains thyroglobulin type-1, follistatin-like, and calcium-binding domains, and has glycosaminoglycan attachment sites in the acidic C-terminal region. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.
SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2
, sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2
, granule cell antiserum positive 26