Browse our anti-HtrA Serine Peptidase 1 (HTRA1) Antibodies

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anti-HtrA Serine Peptidase 1 Antibodies (HTRA1)
On are 73 HtrA Serine Peptidase 1 (HTRA1) Antibodies from 15 different suppliers available. Additionally we are shipping HtrA Serine Peptidase 1 Kits (29) and HtrA Serine Peptidase 1 Proteins (20) and many more products for this protein. A total of 127 HtrA Serine Peptidase 1 products are currently listed.
AI429470, ARMD7, CARASIL, HTRA, HTRA1, L56, MGC145723, ORF480, Prss11, RSPP11, Xhtra1, zgc:92029, zgc:172061
list all antibodies Gene Name GeneID UniProt
HTRA1 5654 Q92743
HTRA1 56213 Q9R118
HTRA1 65164 Q9QZK5

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Most Popular Reactivities for anti-HtrA Serine Peptidase 1 (HTRA1) Antibodies

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Top referenced anti-HtrA Serine Peptidase 1 Antibodies

  1. Human Polyclonal HTRA1 Primary Antibody for IHC (p), WB - ABIN388128 : Chamberland, Wang, Jones, Collins-Racie, LaVallie, Huang, Liu, Morris, Flannery, Yang: Identification of a novel HtrA1-susceptible cleavage site in human aggrecan: evidence for the involvement of HtrA1 in aggrecan proteolysis in vivo. in The Journal of biological chemistry 2009 (PubMed)
    Show all 5 references for 388128

  2. Human Polyclonal HTRA1 Primary Antibody for IF, IHC (p) - ABIN388127 : Hu, Carozza, Klein, Nantermet, Luk, Crowl: Human HtrA, an evolutionarily conserved serine protease identified as a differentially expressed gene product in osteoarthritic cartilage. in The Journal of biological chemistry 1999 (PubMed)
    Show all 5 references for 388127

  3. Human Polyclonal HTRA1 Primary Antibody for EIA, IHC (p) - ABIN356844 : Howes, Lerch, Greenhalf, Stocken, Ellis, Simon, Truninger, Ammann, Cavallini, Charnley, Uomo, Delhaye, Spicak, Drumm, Jansen, Mountford, Whitcomb, Neoptolemos: Clinical and genetic characteristics of hereditary pancreatitis in Europe. in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2004 (PubMed)
    Show all 3 references for 356844

  4. Cow (Bovine) Polyclonal HTRA1 Primary Antibody for ICC, IF - ABIN4320643 : Clawson, Bui, Xin, Wang, Pan: Intracellular localization of the tumor suppressor HtrA1/Prss11 and its association with HPV16 E6 and E7 proteins. in Journal of cellular biochemistry 2008 (PubMed)
    Show all 2 references for 4320643

  5. Human Polyclonal HTRA1 Primary Antibody for ICC, IF - ABIN4320641 : Wang, Eckert, Zomorrodi, Xin, Pan, Shearer, Weisz, Maranus, Clawson: Down-regulation of HtrA1 activates the epithelial-mesenchymal transition and ATM DNA damage response pathways. in PLoS ONE 2012 (PubMed)

More Antibodies against HtrA Serine Peptidase 1 Interaction Partners

Zebrafish HtrA Serine Peptidase 1 (HTRA1) interaction partners

  1. HtrA1 is indispensable for dorsoventral patterning in early zebrafish embryogenesis and serves as a key upstream regulator of FGF signaling through the control of FGF levels.

Rhesus Monkey HtrA Serine Peptidase 1 (HTRA1) interaction partners

  1. Our data point to a yet unexpected effect of decreased HTRA1 expression on drusen pathogenesis. Thus not only a higher HTRA1 expression, but an imbalance of HTRA1 might be disease-relevant.

  2. Tests for association revealed a variant in the promoter region of HTRA1 and two variants in the 5'-UTR (show UTS2R Antibodies) of ARMS2 (show ARMS2 Antibodies) to be associated with drusen.

  3. As in humans, one variant within LOC387715/ARMS2 (show ARMS2 Antibodies) and one in HTRA1 were significantly associated with age-related macular degeneration.

Human HtrA Serine Peptidase 1 (HTRA1) interaction partners

  1. Results show that HTRA1 is epigenetically silenced in HCT116 colon carcinoma cells and during early stages of tumorigenesis in a mouse model of intestinal cancer. Downregulation of HTRA1 causes a multiple phenotypes that are hallmarks of cancer cells including increased proliferation of mouse embryonic fibroblasts, as well as chromosome and centrosome amplifications.

  2. High HTRA1 expression is associated with cervical cell proliferation.

  3. Data indicate HtrA serine peptidase 1 (HTRA1) involvement in Age-related macular degeneration (AMD (show AMD1 Antibodies)) pathogenesis.

  4. Variants in HTRA1 are not associated with age-related macular degeneration.

  5. Results show the heterozygous missense mutations p.G283E, p.P285L, p.R302Q, and p.T319I in the HTRA1 gene in 8 patients with symptomatic cerebral small vessel disease; mutant HTRA1s observed in manifesting heterozygotes might result in an impaired HTRA1 activation cascade of HTRA1 or be unable to form stable trimers

  6. FN and HtrA1 are localized in the placental key growth zones suggesting a pivotal role in maintaining the balance among the molecules involved in the placental development and differentiation

  7. correlation between TGFb1 (show TGFB1 Antibodies) and pSmad2 as well as between HtrA1 and TGFb1 (show TGFB1 Antibodies) and the very significant increase of Ki67 (show MKI67 Antibodies) in stromal compartment of eutopic endometrium suggest a possible involvement of HtrA1 in the pathogenesis of endometriosis.

  8. Two synonymous polymorphisms in exon 1 of the HTRA1 gene result in a protein with altered thermophoretic properties.

  9. significant increase of serum HtrA1 in early-onset pre-eclampsia

  10. a frameshift mutation in the HTRA1 gene detected in a CARASIL pedigree resulted in reduced HTRA1 protein and increased TGF-beta1 (show TGFB1 Antibodies) expression, which may cause severe CARASIL and peripheral small arterial disease

Mouse (Murine) HtrA Serine Peptidase 1 (HTRA1) interaction partners

  1. transfection of cells with a constitutively active rapamycin-resistant p70S6K (show RPS6KB1 Antibodies) mutant could restore the mineralizing capacity of HtrA1-deficient mouse adipose-derived stromal cells.

  2. Increased expressions of Tgf-beta1 (show TGFB1 Antibodies), p-Smad2 (show SMAD2 Antibodies)/3 and HtrA1 were detected in the articular chondrocytes of knee joints in models of osteoarthritis.

  3. In mouse brain tissue and embryonic fibroblasts there is a facilitating role of HtrA1 in TGF-beta (show TGFB1 Antibodies) pathway activation.

  4. HtrA1 plays important roles in the differentiation of trophoblasts from Tpbpa-positive precursors in the ectoplacental cone

  5. The HtrA1 overexpression and mainstream cigarette smoke can independently lead to CNV. The HtrA1 gene is a strong risk factor for wet AMD (show AMD1 Antibodies)

  6. the inhibitory effect of IFN-gamma (show IFNG Antibodies) on HTRA1 expression was evidenced in collagen-induced arthritis (CIA (show NCOA5 Antibodies)) mouse models and in human RA synovial cells.

  7. Serine protease HTRA1 antagonizes transforming growth factor-beta signaling by cleaving its receptors and loss of HTRA1 in vivo enhances bone formation.

  8. Data show that HtrA1 is produced during osteoclastogenesis, and negatively regulates osteoblast differentiation, osteoblast differentiation and BMP2 (show BMP2 Antibodies)-induced Smad1 (show SMAD1 Antibodies)/5/8, ERK1/2 (show MAPK1/3 Antibodies) and p38 (show CRK Antibodies) phosphorylation in pre-osteoblasts.

  9. This study offers new insights into the regulation of HTRA-1 expression via LPS (show TLR4 Antibodies)/TLR-4 (show TLR4 Antibodies) and the role of HTRA-1 in rheumatoid arthrisis pathogenesis.

  10. suggest a critical role for LRP1 (show LRP1 Antibodies) in maintaining the integrity of vessels by regulating protease activity as well as matrix deposition by modulating HtrA1 and connective tissue growth factor (show CTGF Antibodies) protein levels.

Xenopus laevis HtrA Serine Peptidase 1 (HTRA1) interaction partners

  1. The results are consistent with a mechanism by which xHtrA1, through cleaving proteoglycans, releases cell-surface-bound Fibroblast Growth Factors (FGF) ligands and stimulates long-range FGF signaling.

HtrA Serine Peptidase 1 (HTRA1) Antigen Profile

Antigen Summary

This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth. Variations in the promoter region of this gene are the cause of susceptibility to age-related macular degeneration type 7.

Alternative names and synonyms associated with HtrA Serine Peptidase 1 (HTRA1)

  • HtrA serine peptidase 1a (htra1a) antibody
  • HtrA serine peptidase 1 (HTRA1) antibody
  • HtrA serine peptidase 1b (htra1b) antibody
  • HtrA serine peptidase 1 (htra1) antibody
  • Serine protease HTRA1 (htra1) antibody
  • HtrA serine peptidase 1 (Htra1) antibody
  • serine protease (HTRA) antibody
  • AI429470 antibody
  • ARMD7 antibody
  • CARASIL antibody
  • HTRA antibody
  • HTRA1 antibody
  • L56 antibody
  • MGC145723 antibody
  • ORF480 antibody
  • Prss11 antibody
  • RSPP11 antibody
  • Xhtra1 antibody
  • zgc:92029 antibody
  • zgc:172061 antibody

Protein level used designations for HTRA1

HtrA serine peptidase 1 , high-temperature requirement A serine peptidase 1A , serine protease 11 , serine protease HTRA1A , high-temperature requirement A serine peptidase 1B , serine protease HTRA1B , high temperature required A1 , Serine protease HTRA1 , IGFBP5-protease , high-temperature requirement A serine peptidase 1 , protease, serine, 11 (IGF binding) , serine protease HTRA1 , insulin-like growth factor binding protein 5 protease , protease, serine, 11 (Igf binding) , IGF binding , protease, serine, 11 , protease serine 11 , High-temperature requirement A serine peptidase 1 , Serine protease 11

431766 Danio rerio
450792 Pan troglodytes
565082 Danio rerio
705855 Macaca mulatta
780187 Xenopus (Silurana) tropicalis
100064570 Equus caballus
100196695 Salmo salar
100541363 Meleagris gallopavo
100564246 Anolis carolinensis
100583976 Nomascus leucogenys
5654 Homo sapiens
56213 Mus musculus
477852 Canis lupus familiaris
282326 Bos taurus
65164 Rattus norvegicus
496061 Xenopus laevis
100857572 Gallus gallus
100008705 Oryctolagus cuniculus
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