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results explain how loss of the amino terminus in iRhom1 (show RHBDF1 ELISA Kits) and iRhom2 impairs TNF (show TNF ELISA Kits) signaling, despite enhancing ADAM17 (show ADAM17 ELISA Kits) activity
Tylosis with oesophageal cancer-associated mutations in iRHOM2 cause an increase in the maturation and activity of ADAM17 (show ADAM17 ELISA Kits) in epidermal keratinocytes.
Our analyses suggest that these DNA methylation (show HELLS ELISA Kits) changes may have a role in the onset of Alzheimer disease given that we observed them in presymptomatic subjects and that six of the validated genes connect to a known susceptibility gene network.
RHBDF2 and CYGB (show CYGB ELISA Kits) may play distinctive roles in ovarian cancer and could be added to the growing roster of chromosome 17 genes implicated in this disease.
The distribution of RHBDF2 in tylotic skin is altered in comparison with that in normal skin.
baseline expression of genes acting within the NRF2 (show NFE2L2 ELISA Kits) anti-oxidative pathway, followed by gene alterations associated with the integrin receptor aggregation pathway and the FcgammaR-mediated phagocytosis pathway, contribute to accelerated wound healing
the critical role of the transmembrane domains of ADAM17 (show ADAM17 ELISA Kits) and Rhbdf2 in the regulation of the ADAM17 (show ADAM17 ELISA Kits) and EGFR (show EGFR ELISA Kits), and ADAM17 (show ADAM17 ELISA Kits) and TNFalpha (show TNF ELISA Kits) signaling pathways, was examined.
this study shows that the iRhom2/ADAM17 (show ADAM17 ELISA Kits) pathway plays an important role in regulating CSF1R (show CSF1R ELISA Kits) expression in the myeloid cell compartment at steady state, and in modulating development of monocytes/macrophages during their repopulation
this study shows that iRhom2-deficient mice were more susceptible to lethal herpes simplex virus type 1 infection, and that iRhom2 is essential for STING activity, as it regulates TRAPbeta-mediated translocation and EIF3S5-mediated deubiquitination of STING
This study identifies iRhom2 as a novel regulator for determination of keratinocyte lineages.
IRhom2 may be a promising therapeutic target for LPS (show TLR4 ELISA Kits)-induced cardiac injury.
iRhom2 is required for the maturation of TACE (show ADAM17 ELISA Kits) and hair follicle differentiation.
a principal function of iRhoms1/2 during mouse development is to regulate ADAM17 (show ADAM17 ELISA Kits)-dependent EGFR (show EGFR ELISA Kits) signaling
Rhbdf2 mutations increase its protein stability and drive EGFR (show EGFR ELISA Kits) hyperactivation through enhanced secretion of amphiregulin (show AREG ELISA Kits).
findings uncover functions for iRhom2 in the regulation of EGFR (show EGFR ELISA Kits) signaling and in controlling the activation and substrate selectivity of ADAM17 (show ADAM17 ELISA Kits)-dependent shedding events
Rhomboid protease-like protein which has no protease activity but regulates the secretion of several ligands of the epidermal growth factor receptor. Indirectly activates the epidermal growth factor receptor signaling pathway and may thereby regulate sleep, cell survival, proliferation and migration (By similarity).
, inactive rhomboid protein 2
, rhomboid family member 2
, rhomboid veinlet-like protein 5
, rhomboid veinlet-like protein 6
, rhomboid, veinlet-like 6
, rhomboid-like protein 6
, rhomboid-related protein
, Rhomboid family member 2
, rhomboid veinlet-like 6