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results explain how loss of the amino terminus in iRhom1 (show RHBDF1 Proteins) and iRhom2 impairs TNF (show TNF Proteins) signaling, despite enhancing ADAM17 (show ADAM17 Proteins) activity
Tylosis with oesophageal cancer-associated mutations in iRHOM2 cause an increase in the maturation and activity of ADAM17 (show ADAM17 Proteins) in epidermal keratinocytes.
Our analyses suggest that these DNA methylation (show HELLS Proteins) changes may have a role in the onset of Alzheimer disease given that we observed them in presymptomatic subjects and that six of the validated genes connect to a known susceptibility gene network.
RHBDF2 and CYGB (show CYGB Proteins) may play distinctive roles in ovarian cancer and could be added to the growing roster of chromosome 17 genes implicated in this disease.
The distribution of RHBDF2 in tylotic skin is altered in comparison with that in normal skin.
baseline expression of genes acting within the NRF2 (show NFE2L2 Proteins) anti-oxidative pathway, followed by gene alterations associated with the integrin receptor aggregation pathway and the FcgammaR-mediated phagocytosis pathway, contribute to accelerated wound healing
the critical role of the transmembrane domains of ADAM17 (show ADAM17 Proteins) and Rhbdf2 in the regulation of the ADAM17 (show ADAM17 Proteins) and EGFR (show EGFR Proteins), and ADAM17 (show ADAM17 Proteins) and TNFalpha (show TNF Proteins) signaling pathways, was examined.
this study shows that the iRhom2/ADAM17 (show ADAM17 Proteins) pathway plays an important role in regulating CSF1R (show CSF1R Proteins) expression in the myeloid cell compartment at steady state, and in modulating development of monocytes/macrophages during their repopulation
this study shows that iRhom2-deficient mice were more susceptible to lethal herpes simplex virus type 1 infection, and that iRhom2 is essential for STING activity, as it regulates TRAPbeta (show SSR2 Proteins)-mediated translocation and EIF3S5 (show EIF3F Proteins)-mediated deubiquitination of STING
This study identifies iRhom2 as a novel regulator for determination of keratinocyte lineages.
IRhom2 may be a promising therapeutic target for LPS (show TLR4 Proteins)-induced cardiac injury.
iRhom2 is required for the maturation of TACE (show ADAM17 Proteins) and hair follicle differentiation.
a principal function of iRhoms1/2 during mouse development is to regulate ADAM17 (show ADAM17 Proteins)-dependent EGFR (show EGFR Proteins) signaling
Rhbdf2 mutations increase its protein stability and drive EGFR (show EGFR Proteins) hyperactivation through enhanced secretion of amphiregulin (show AREG Proteins).
findings uncover functions for iRhom2 in the regulation of EGFR (show EGFR Proteins) signaling and in controlling the activation and substrate selectivity of ADAM17 (show ADAM17 Proteins)-dependent shedding events
Rhomboid protease-like protein which has no protease activity but regulates the secretion of several ligands of the epidermal growth factor receptor. Indirectly activates the epidermal growth factor receptor signaling pathway and may thereby regulate sleep, cell survival, proliferation and migration (By similarity).
, inactive rhomboid protein 2
, rhomboid family member 2
, rhomboid veinlet-like protein 5
, rhomboid veinlet-like protein 6
, rhomboid, veinlet-like 6
, rhomboid-like protein 6
, rhomboid-related protein
, Rhomboid family member 2
, rhomboid veinlet-like 6