Browse our anti-TGFBR1 (TGFBR1) Antibodies

Full name:
anti-Transforming Growth Factor, beta Receptor 1 Antibodies (TGFBR1)
On www.antibodies-online.com are 138 Transforming Growth Factor, beta Receptor 1 (TGFBR1) Antibodies from 29 different suppliers available. Additionally we are shipping TGFBR1 Kits (26) and TGFBR1 Proteins (18) and many more products for this protein. A total of 194 TGFBR1 products are currently listed.
Synonyms:
AAT5, ACVRLK4, Alk-5, Alk5, AU017191, LDS1A, LDS2A, MSSE, Skr4, TbetaR-I, TbetaRI, TGFBR1, Tgfr-1, x-trr1
list all antibodies Gene Name GeneID UniProt
TGFBR1 7046 P36897
TGFBR1 29591  
TGFBR1 21812 Q64729

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anti-Human TGFBR1 Antibodies:

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anti-Mouse (Murine) TGFBR1 Antibodies:

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Top referenced anti-TGFBR1 Antibodies

  1. Human Polyclonal TGFBR1 Primary Antibody for FACS, IF (p) - ABIN671256 : Xie, Chen, Miao, Tang, Fu: Regulation of cellular behaviors of fibroblasts related to wound healing by sol-gel derived bioactive glass particles. in Journal of biomedical materials research. Part A 2016 (PubMed)
    Show all 3 references for 671256

  2. Human Polyclonal TGFBR1 Primary Antibody for EIA, IHC (p) - ABIN360163 : Itoh, Thorikay, Kowanetz, Moustakas, Itoh, Heldin, ten Dijke: Elucidation of Smad requirement in transforming growth factor-beta type I receptor-induced responses. in The Journal of biological chemistry 2003 (PubMed)
    Show all 3 references for 360163

  3. Human Polyclonal TGFBR1 Primary Antibody for IF, ELISA - ABIN1450347 : Franzén, ten Dijke, Ichijo, Yamashita, Schulz, Heldin, Miyazono: Cloning of a TGF beta type I receptor that forms a heteromeric complex with the TGF beta type II receptor. in Cell 1993 (PubMed)
    Show all 2 references for 1450347

  4. Human Polyclonal TGFBR1 Primary Antibody for IHC (p), WB - ABIN392279 : Miles, Tung, Aguiar, Kurtoglu, Sikes: Increased TGF-?1-mediated suppression of growth and motility in castrate-resistant prostate cancer cells is consistent with Smad2/3 signaling. in The Prostate 2012 (PubMed)
    Show all 2 references for 392279

  5. Human Polyclonal TGFBR1 Primary Antibody for IF, ELISA - ABIN1532728 : Vellucci, Reiss: Cloning and genomic organization of the human transforming growth factor-beta type I receptor gene. in Genomics 1998 (PubMed)
    Show all 2 references for 1532728

  6. Human Polyclonal TGFBR1 Primary Antibody for IF, WB - ABIN317892 : Yu, Hu, Yang, Takemori, Li, Zheng, Hong, Liao, Wen: Salt-inducible kinase 1 is involved in high glucose-induced mesangial cell proliferation mediated by the ALK5 signaling pathway. in International journal of molecular medicine 2013 (PubMed)

  7. Mouse (Murine) Monoclonal TGFBR1 Primary Antibody for FACS - ABIN4896299 : Bodogai, Moritoh, Lee-Chang, Hollander, Sherman-Baust, Wersto, Araki, Miyoshi, Yang, Trinchieri, Biragyn: Immunosuppressive and Prometastatic Functions of Myeloid-Derived Suppressive Cells Rely upon Education from Tumor-Associated B Cells. in Cancer research 2015 (PubMed)

More Antibodies against TGFBR1 Interaction Partners

Human Transforming Growth Factor, beta Receptor 1 (TGFBR1) interaction partners

  1. Overexpression of truncated ALK5 in a B-cell line counteracted BMP-7 (show BMP7 Antibodies)-induced apoptosis, whereas overexpression of truncated ALK4 (show ACVR1B Antibodies) had no effect.

  2. Although TGFbeta1 (show TGFB1 Antibodies)/2 receptors are downregulated in breast cancer, their expression in tumors is an indicator of aggressive breast cancer phenotype.

  3. Higher proportions of early-onset Diffuse Gastric Cancers (DGCs) contained somatic mutations in CDH1 (show CDH1 Antibodies) or TGFBR1 compared with late-onset DGCs. A smaller proportion of early-onset DGCs contained somatic mutations in RHOA (show RHOA Antibodies). CDH1 (show CDH1 Antibodies) alterations, but not RHOA (show RHOA Antibodies) mutations, were associated with shorter survival times. Female predominance in early-onset DGC (show GGCX Antibodies) may be related to relatively high rates of somatic CDH1 (show CDH1 Antibodies) and TGFBR1 mutations.

  4. Coronin 1B (show CORO1B Antibodies) constitutively binds to TGF beta (show TGFB1 Antibodies) receptor I in vascular smooth muscle cells.

  5. BIX02189 is a potent inhibitor of TGF-beta type I receptor that can block the lung tumor metastatic activity of TGF-beta1 (show TGFB1 Antibodies).

  6. These results suggest that polymorphisms in TGFB1 (show TGFB1 Antibodies), TGFBR1, SNAI1 (show SNAI1 Antibodies) and TWIST1 (show TWIST1 Antibodies) may modulate endometrial cancer susceptibility, both separately and corporately.

  7. In luciferase assays, the risk-associated allele for rs868 was associated with half the luciferase expression in the presence of miRNA let-7b-5p compared with protective allele, suggesting more binding of let-7b-5p and less TGFBR1 expression. Thus, rs868 potentially is acolorectal ca CRC (show CALR Antibodies) risk-causing allele. Our results support the concept that rs868 is associated with lower TGFBR1 expression thereby increasing CRC (show CALR Antibodies) risk.

  8. Data show that signal transducing adaptor proteins APPL1 and APPL2 are required for TGFbeta-induced nuclear translocation of TGFbeta type I receptor (TbetaRI)-ICD and for cancer cell invasiveness of prostate and breast cancer cell lines.

  9. Evidence supporting a genetic basis includes the autosomal dominance of Bicuspid aortic valve inheritance patterns, and the identification of mutations in transforming growth factor beta receptor 1.

  10. This work details a novel mechanism by which cellular tension regulates TGFbeta (show TGFB1 Antibodies) receptor organization, multimerization, and function.

Pig (Porcine) Transforming Growth Factor, beta Receptor 1 (TGFBR1) interaction partners

  1. The results indicate that the TGFBR1 gene polymorphism (SNP64) is significantly associated with growth rates including average daily gains between birth and 56 kg, between 5.5 and 56 kg, between 35 and 56 kg.

  2. Report temporal regulation of TGFBR1 mRNA expression in the oocyte, granulosa and theca cells of developing preovulatory follicles in the pig.

  3. TGFbeta (show TGFB1 Antibodies) is abundant in boar seminal plasma, thus TGFbeta (show TGFB1 Antibodies) may be a male-female signalling agent involved in immune changes in the female reproductive tract elicited by seminal fluid.

  4. Porcine transforming growth factor beta receptor 1 has many polymorphisms, including two nonsynonymous substitutions in exons 1 and 7 and novel alternative splicing in exon 3.

  5. isolation and molecular characterization; the full-length TGFBR1 cDNA 1813 bp contains an open reading frame (ORF) of 1512 bp encoding a TGFBR1 protein of 503 amino acids with a calculated molecular weight of 56.4 kDa.

Cow (Bovine) Transforming Growth Factor, beta Receptor 1 (TGFBR1) interaction partners

  1. Results show that ALK5 and ALK1 (show ACVRL1 Antibodies) play antagonistic roles in TGF-beta (show TGFB1 Antibodies)-induced podosome formation in aortic endothelial cells.

  2. This study showed that ubiquitinated ALK5 and phosphorylated heat shock protein 27 specifically accumulate in the cytoskeleton fraction, and ALK1 (show ACVRL1 Antibodies) and ALK5 interact with heat shock protein 90 (show HSP90 Antibodies).

  3. GM-CSF (show CSF2 Antibodies) induced airway smooth muscle cells to increase expression of transforming growth factor (TGF)-beta (show TGFB1 Antibodies) receptors type I, II, and III, but had no detectable effect on the release of TGF-beta1 (show TGFB1 Antibodies) by the same ASMC; corticosteroids were inhibitory

  4. ALK5 and Smad4 (show SMAD4 Antibodies) have roles in TGF-beta1 (show TGFB1 Antibodies)-induced pulmonary endothelial permeability

  5. These results indicate that high plasma cholesterol levels may contribute to the pathogenesis of certain diseases (e.g., atherosclerosis) by suppressing TGF-beta (show TGFB1 Antibodies) responsiveness.

  6. Transforming growth factor-beta1 protects against pulmonary artery endothelial cell apoptosis via ALK5.

  7. ALK1 and ALK5 are both essential for correct regulation of VEGF, and that disruption of either pathway leads to disease.

  8. TGF-beta1 (show TGFB1 Antibodies) downregulates caveolin-1 (show CAV1 Antibodies) of cultured endothelial cells, involving ALK-5 receptor subtype

Mouse (Murine) Transforming Growth Factor, beta Receptor 1 (TGFBR1) interaction partners

  1. fluid shear stress induces autocrine TGF-beta (show TGFB1 Antibodies)/ALK5-induced target gene expression in renal epithelial cells, which is partially restrained by MEK1 (show MAP2K1 Antibodies)/2-mediated signaling.

  2. both GDF-15 (show GDF15 Antibodies) and TGF-beta1 (show TGFB1 Antibodies) counteract chemokine (show CCL1 Antibodies)-induced integrin activation on neutrophils via the ALK-5/TGF-betaRII heterodimer.

  3. CD109 (show CD109 Antibodies) differentially regulates TGF-beta (show TGFB1 Antibodies)-induced ALK1 (show ACVRL1 Antibodies)-Smad1 (show SMAD1 Antibodies)/5 versus ALK5-Smad2 (show SMAD2 Antibodies)/3 pathways, leading to decreased extracellular matrix production in the skin; epidermal CD109 (show CD109 Antibodies) expression regulates dermal function through a paracrine mechanism

  4. miR (show MLXIP Antibodies)-27b is an anti-fibrotic microRNA that inhibits fibroblast activation by targeting TGFbeta (show TGFB1 Antibodies) receptor 1 and SMAD2 (show SMAD2 Antibodies).

  5. In the presence of gadolinium and antibeta1 integrin antibody, collagen regulated the expression levels of Tgfbr1, Tgfbr2 (show TGFBR2 Antibodies) and Smad2 (show SMAD2 Antibodies)/3, but did not alter the phosphorylation of p38 (show CRK Antibodies), ERK1/2 (show MAPK1/3 Antibodies) or JNK (show MAPK8 Antibodies).

  6. miR (show MLXIP Antibodies)-22 acts as a novel negative regulator of angiotensin II-induced cardiac fibrosis by suppressing the expression of TGFbetaRI in the heart.

  7. TGFbetaRI inhibition in an injured adult heart could both stimulate the autocrine/paracrine activity of survivin (show BIRC5 Antibodies) and inhibit Wnt (show WNT2 Antibodies) in CPCs to mediate cardioprotection and improve cardiac function.

  8. Data show that transforming growth factor-beta receptor I (Tgfbr1) was a direct target of microRNA miR (show MLXIP Antibodies)-140-5p.

  9. Targeted early inactivation of Alk5 in mesodermal progenitors caused abnormal development and maturation of the lung that included reduced physical size of the sub-mesothelial mesoderm, an established source of specific mesodermal progenitors.

  10. Beclin 1 (show BECN1 Antibodies) regulates neuronal transforming growth factor-beta signaling by mediating recycling of the type I receptor ALK5

TGFBR1 Antigen Profile

Antigen Summary

The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with TGFBR1

  • transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa) (TGFBR1) antibody
  • transforming growth factor, beta receptor 1 (tgfbr1) antibody
  • transforming growth factor, beta receptor 1 (TGFBR1) antibody
  • transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa) (LOC100230911) antibody
  • transforming growth factor, beta receptor 1 (Tgfbr1) antibody
  • transforming growth factor, beta receptor I (Tgfbr1) antibody
  • AAT5 antibody
  • ACVRLK4 antibody
  • Alk-5 antibody
  • Alk5 antibody
  • AU017191 antibody
  • LDS1A antibody
  • LDS2A antibody
  • MSSE antibody
  • Skr4 antibody
  • TbetaR-I antibody
  • TbetaRI antibody
  • TGFBR1 antibody
  • Tgfr-1 antibody
  • x-trr1 antibody

Protein level used designations for TGFBR1

TGF-beta receptor type-1 , type I serine/threonine kinase receptor , transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa) , transforming growth factor beta type I receptor , transforming growth factor, beta receptor 1 (activin A receptor type II-like kinase, 53kDa) , transforming growth factor, beta receptor 1 , transforming growth factor beta receptor 1 , TGF-beta receptor type-1-like , TGF-beta receptor type I , TGF-beta type I receptor , activin A receptor type II-like kinase, 53kD , activin A receptor type II-like kinase, 53kDa , activin A receptor type II-like protein kinase of 53kD , activin receptor-like kinase 5 , serine/threonine-protein kinase receptor R4 , tbetaR-I , transforming growth factor beta receptor I , transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kD) , transforming growth factor-beta receptor type I , transforming growth factor, beta receptor I , TGFR-1 , activin A receptor type II-like kinase , transforming growth factor beta receptor type I , transforming growth factor beta, receptor 1 , ESK2

GENE ID SPECIES
374094 Gallus gallus
399295 Xenopus laevis
403428 Canis lupus familiaris
472992 Pan troglodytes
481628 Canis lupus familiaris
548715 Xenopus (Silurana) tropicalis
554326 Ovis aries
714952 Macaca mulatta
100230911 Taeniopygia guttata
100389596 Callithrix jacchus
100450864 Pongo abelii
100592854 Nomascus leucogenys
7046 Homo sapiens
29591 Rattus norvegicus
396665 Sus scrofa
282382 Bos taurus
21812 Mus musculus
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