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Human TGFBR1 ELISA Kit for Sandwich ELISA - ABIN416726
Zhang, Chen, Chen, Meng, Xiong, Liu, Jin, Tao, Wu, Sun: TGF-β/BAMBI pathway dysfunction contributes to peripheral Th17/Treg imbalance in chronic obstructive pulmonary disease. in Scientific reports 2016
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Aortic diseases in patients with TGFBR1 or TGFBR2 (show TGFBR2 ELISA Kits) mutations show the same prevalence of systemic features and the same global survival.
Results show that TGFBR1 expression is regulated in bladder cancer cell through its desumoylation by SENP2.
Low TGFBR1 expression is associated with oral cancer progression.
TGF-beta (show TGFB1 ELISA Kits) type I, II, and III receptors were all identified in pregnant serum; all were substantially elevated in early-onset but not late-onset preeclampsia. Endoglin (show ENG ELISA Kits) was increased in both subtypes.
Overexpression of truncated ALK5 in a B-cell line counteracted BMP-7 (show BMP7 ELISA Kits)-induced apoptosis, whereas overexpression of truncated ALK4 (show ACVR1B ELISA Kits) had no effect.
Although TGFbeta1 (show TGFB1 ELISA Kits)/2 receptors are downregulated in breast cancer, their expression in tumors is an indicator of aggressive breast cancer phenotype.
Higher proportions of early-onset Diffuse Gastric Cancers (DGCs) contained somatic mutations in CDH1 (show CDH1 ELISA Kits) or TGFBR1 compared with late-onset DGCs. A smaller proportion of early-onset DGCs contained somatic mutations in RHOA (show RHOA ELISA Kits). CDH1 (show CDH1 ELISA Kits) alterations, but not RHOA (show RHOA ELISA Kits) mutations, were associated with shorter survival times. Female predominance in early-onset DGC (show GGCX ELISA Kits) may be related to relatively high rates of somatic CDH1 (show CDH1 ELISA Kits) and TGFBR1 mutations.
Coronin 1B (show CORO1B ELISA Kits) constitutively binds to TGF beta (show TGFB1 ELISA Kits) receptor I in vascular smooth muscle cells.
BIX02189 is a potent inhibitor of TGF-beta type I receptor that can block the lung tumor metastatic activity of TGF-beta1 (show TGFB1 ELISA Kits).
These results suggest that polymorphisms in TGFB1 (show TGFB1 ELISA Kits), TGFBR1, SNAI1 (show SNAI1 ELISA Kits) and TWIST1 (show TWIST1 ELISA Kits) may modulate endometrial cancer susceptibility, both separately and corporately.
The results indicate that the TGFBR1 gene polymorphism (SNP64) is significantly associated with growth rates including average daily gains between birth and 56 kg, between 5.5 and 56 kg, between 35 and 56 kg.
Report temporal regulation of TGFBR1 mRNA expression in the oocyte, granulosa and theca cells of developing preovulatory follicles in the pig.
TGFbeta (show TGFB1 ELISA Kits) is abundant in boar seminal plasma, thus TGFbeta (show TGFB1 ELISA Kits) may be a male-female signalling agent involved in immune changes in the female reproductive tract elicited by seminal fluid.
Porcine transforming growth factor beta receptor 1 has many polymorphisms, including two nonsynonymous substitutions in exons 1 and 7 and novel alternative splicing in exon 3.
isolation and molecular characterization; the full-length TGFBR1 cDNA 1813 bp contains an open reading frame (ORF) of 1512 bp encoding a TGFBR1 protein of 503 amino acids with a calculated molecular weight of 56.4 kDa.
Results show that ALK5 and ALK1 (show ACVRL1 ELISA Kits) play antagonistic roles in TGF-beta (show TGFB1 ELISA Kits)-induced podosome formation in aortic endothelial cells.
This study showed that ubiquitinated ALK5 and phosphorylated heat shock protein 27 (show HSP27 ELISA Kits) specifically accumulate in the cytoskeleton fraction, and ALK1 (show ACVRL1 ELISA Kits) and ALK5 interact with heat shock protein 90 (show HSP90 ELISA Kits).
GM-CSF (show CSF2 ELISA Kits) induced airway smooth muscle cells to increase expression of transforming growth factor (TGF)-beta (show TGFB1 ELISA Kits) receptors type I, II, and III, but had no detectable effect on the release of TGF-beta1 (show TGFB1 ELISA Kits) by the same ASMC; corticosteroids were inhibitory
ALK5 and Smad4 (show SMAD4 ELISA Kits) have roles in TGF-beta1 (show TGFB1 ELISA Kits)-induced pulmonary endothelial permeability
These results indicate that high plasma cholesterol levels may contribute to the pathogenesis of certain diseases (e.g., atherosclerosis) by suppressing TGF-beta (show TGFB1 ELISA Kits) responsiveness.
Transforming growth factor-beta1 protects against pulmonary artery endothelial cell apoptosis via ALK5.
ALK1 and ALK5 are both essential for correct regulation of VEGF, and that disruption of either pathway leads to disease.
TGF-beta1 (show TGFB1 ELISA Kits) downregulates caveolin-1 (show CAV1 ELISA Kits) of cultured endothelial cells, involving ALK-5 receptor subtype
Conditional deletion of Tgfbr1 in PTEN-inactivated endometrium leads to a disease that recapitulates invasive and lethal human endometrial cancer.
fluid shear stress induces autocrine TGF-beta (show TGFB1 ELISA Kits)/ALK5-induced target gene expression in renal epithelial cells, which is partially restrained by MEK1 (show MAP2K1 ELISA Kits)/2-mediated signaling.
both GDF-15 (show GDF15 ELISA Kits) and TGF-beta1 (show TGFB1 ELISA Kits) counteract chemokine (show CCL1 ELISA Kits)-induced integrin activation on neutrophils via the ALK-5/TGF-betaRII heterodimer.
CD109 (show CD109 ELISA Kits) differentially regulates TGF-beta (show TGFB1 ELISA Kits)-induced ALK1 (show ACVRL1 ELISA Kits)-Smad1 (show SMAD1 ELISA Kits)/5 versus ALK5-Smad2 (show SMAD2 ELISA Kits)/3 pathways, leading to decreased extracellular matrix production in the skin; epidermal CD109 (show CD109 ELISA Kits) expression regulates dermal function through a paracrine mechanism
miR (show MLXIP ELISA Kits)-27b is an anti-fibrotic microRNA that inhibits fibroblast activation by targeting TGFbeta (show TGFB1 ELISA Kits) receptor 1 and SMAD2 (show SMAD2 ELISA Kits).
In the presence of gadolinium and antibeta1 integrin antibody, collagen regulated the expression levels of Tgfbr1, Tgfbr2 (show TGFBR2 ELISA Kits) and Smad2 (show SMAD2 ELISA Kits)/3, but did not alter the phosphorylation of p38 (show CRK ELISA Kits), ERK1/2 (show MAPK1/3 ELISA Kits) or JNK (show MAPK8 ELISA Kits).
miR (show MLXIP ELISA Kits)-22 acts as a novel negative regulator of angiotensin II-induced cardiac fibrosis by suppressing the expression of TGFbetaRI in the heart.
TGFbetaRI inhibition in an injured adult heart could both stimulate the autocrine/paracrine activity of survivin (show BIRC5 ELISA Kits) and inhibit Wnt (show WNT2 ELISA Kits) in CPCs to mediate cardioprotection and improve cardiac function.
Data show that transforming growth factor-beta receptor I (Tgfbr1) was a direct target of microRNA miR (show MLXIP ELISA Kits)-140-5p.
Targeted early inactivation of Alk5 in mesodermal progenitors caused abnormal development and maturation of the lung that included reduced physical size of the sub-mesothelial mesoderm, an established source of specific mesodermal progenitors.
The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene.
TGF-beta receptor type-1
, type I serine/threonine kinase receptor
, transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa)
, transforming growth factor beta type I receptor
, transforming growth factor, beta receptor 1 (activin A receptor type II-like kinase, 53kDa)
, transforming growth factor, beta receptor 1
, transforming growth factor beta receptor 1
, TGF-beta receptor type-1-like
, TGF-beta receptor type I
, TGF-beta type I receptor
, activin A receptor type II-like kinase, 53kD
, activin A receptor type II-like kinase, 53kDa
, activin A receptor type II-like protein kinase of 53kD
, activin receptor-like kinase 5
, serine/threonine-protein kinase receptor R4
, transforming growth factor beta receptor I
, transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kD)
, transforming growth factor-beta receptor type I
, transforming growth factor, beta receptor I
, activin A receptor type II-like kinase
, transforming growth factor beta receptor type I
, transforming growth factor beta, receptor 1