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Human desert Hedgehog ELISA Kit for Sandwich ELISA - ABIN418813
Nishimori, Ehata, Suzuki, Katsuno, Miyazono: Prostate cancer cells and bone stromal cells mutually interact with each other through bone morphogenetic protein-mediated signals. in The Journal of biological chemistry 2012
In organogenesis of the ovary, production of Dhh/Ihh (show IHH ELISA Kits) in granulosa cells requires growth differentiation factor 9 (show GDF9 ELISA Kits) from the oocyte.
The results demonstrate a pivotal role for dhh in maintof this study aining myelination. Furthermore, dhh signaling reveals a potential target for therapeutic intervention to prevent and treat demyelination of peripheral nerves in compression neuropathies
Hedgehog (show SHH ELISA Kits) signaling is impaired in aged mice. Hegdehog-dependent regulation of angiogenesis and myogenesis involves distinct mechanisms.
Data indicate that the centrosomal protein DZIP1 interacts with GLI3 (show GLI3 ELISA Kits) transcription factor in the cytoplasm and regulates Hedgehog (show SHH ELISA Kits) signaling and ciliogenesis.
Desert hedgehog promotes ischemia-induced angiogenesis by ensuring peripheral nerve survival.
Desert hedgehog-dependent transcription in T cells promotes T helper (Th)2 cell transcriptional programs and differentiation, exacerbating allergic disease.
During recovery of hematopoiesis after irradiation, and under conditions of stress-induced erythropoiesis, erythrocyte differentiation was accelerated in both spleen and bone marrow of Dhh-deficient mice compared with wild type.
The findings suggest that Sertoli cells coordinate Dhh-dependent spermatogenesis events via Ptc1 and Smo prior to the first meiotic division and in postmeiotic (haploid) cells, particularly during the first half of spermiogenesis.
Desert Hedgehog/Patched 1 (show PTCH1 ELISA Kits) signaling specifies fetal Leydig cell fate in testis organogenesis
Prominent role of hedgehog (show SHH ELISA Kits) signaling in the communication between granulosa cells and developing theca cells.
Single nucleotide polymorphism in the DHH gene is associated with bipolar disorder.
Mutations in DHH play a role in 46,XY gonadal dysgenesis and are associated with seminoma formation and a neuropathy with minifascicle formation.
Findings are unprecedented and indicate that the DHH-RHEBL1 (show RHEBL1 ELISA Kits) fusion transcript is a novel recurrent feature in the changing landscape of CBFA2T3 (show CBFA2T3 ELISA Kits)-GLIS2 (show GLIS2 ELISA Kits)-positive childhood AML (show RUNX1 ELISA Kits).
Mutations in DHH are associated with 46,XY pure gonadal dysgenesis and mixed gonadal dysgenesis.
This study demonistrated that Desert hedgehog links transcription factor Sox10 (show SOX10 ELISA Kits) to peripheral nerve development.
Studies indicate that pathways of Hedgehog (Hh), Wnt and Notch, which regulate development during embryonic life and somatic stem cells (SCs) in the adult organism, can be reactivated in malignancies and support tumor-initiating cells (TIC) scompartment.
Two cases have been described in Indian patients with 46,XY complete gonadal dysgenesis that could be attributable to mutations in the Desert hedgehog (DHH) gene leading to non-functional DHH protein.
We found no significant correlation between the expression of SOX9 (show SOX9 ELISA Kits) and desert hedgehog, and neither SOX9 (show SOX9 ELISA Kits) nor desert hedgehog expression was correlated to the histoprognostic grade in sarcomas.
These data demonstrate that DHH is a key molecule in both male gonadal differentiation and perineurial formation in peripheral nerves
Importance of DHH in mammalian male sexual differentiation, providing extended evidence that DHH constitutes a key gene in gonadal differentiation
characterized two new members of the Hedgehog (show SHH ELISA Kits) (Hh) family in zebrafish, ihha and dhh, encoding for orthologues of the tetrapod Indian Hedgehog (Ihh (show IHH ELISA Kits)) and Desert Hedgehog (Dhh) genes, respectively
This gene encodes a member of the hedgehog family. The hedgehog gene family encodes signaling molecules that play an important role in regulating morphogenesis. This protein is predicted to be made as a precursor that is autocatalytically cleaved\; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the organism. Defects in this protein have been associated with partial gonadal dysgenesis (PGD) accompanied by minifascicular polyneuropathy. This protein may be involved in both male gonadal differentiation and perineurial development.
desert hedgehog homolog
, desert hedgehog
, desert hedgehog protein
, mutant desert hedgehog