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depletion of DYNC2LI1 induced altered cilia morphology with broadened ciliary tips and accumulation of intraflagellar transport complexes (IFT-B) complex proteins in accordance with retrograde IFT defects.
DYNC2LI1 is essential for dynein-2 complex stability and that mutations in DYNC2LI1 result in variable length, including hyperelongated, cilia, Hedgehog (show SHH ELISA Kits) pathway impairment and ciliary IFT accumulations, causing short rib polydactyly syndrome.
May function as a motor for intraflagellar retrograde transport. Functions in cilia biogenesis (By similarity).
dynein, cytoplasmic 2, light intermediate chain 1
, cytoplasmic dynein 2 light intermediate chain 1
, dynein 2 light intermediate chain