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Human Polyclonal HHAT Primary Antibody for FACS, IHC (p) - ABIN651694
Chamoun, Mann, Nellen, von Kessler, Bellotto, Beachy, Basler: Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal. in Science (New York, N.Y.) 2001
Show all 2 references for ABIN651694
Human Polyclonal HHAT Primary Antibody for WB - ABIN2782948
Bergeron, Vincent, Nichol: Crimean-Congo hemorrhagic fever virus glycoprotein processing by the endoprotease SKI-1/S1P is critical for virus infectivity. in Journal of virology 2007
Hhat plays a critical role in ER positive, HER2 (show ERBB2 Antibodies) amplified, and hormone resistant breast cancer proliferation.
Data suggest that substrate specificity of hedgehog acyltransferase (HHAT) in palmitoylation reaction extends to oligopeptide fragments of Sonic hedgehog protein (SHH (show SHH Antibodies)).
three distinct members [porcupine (PORCN (show PORCN Antibodies)), hedgehog (show SHH Antibodies) (Hh) acyltransferase (HHAT) and ghrelin O-acyltransferase (show MBOAT4 Antibodies) (GOAT)] have been shown to acylate specific proteins or peptides.
analysis of hedgehog acyltransferase membrane topology
rs7527939 is the strongest indicator of susceptibility to schizophrenia in the Bulgarian population within the HHAT locus.
SKN is necessary for the proliferation of the non-small cell lung carcinoma cells
These findings define residues and regions within Shh (show SHH Antibodies) that are necessary for its recognition as a substrate for Hhat-mediated palmitoylation.
SKI-1/S1P (show MBTPS1 Antibodies) activity is thus essential for hepatitis C virus production and its inhibition should be considered for antiviral drug development.
Mutations in Hedgehog acyltransferase (Hhat) perturb Hedgehog (show SHH Antibodies) signaling, resulting in severe acrania-holoprosencephaly-agnathia craniofacial defects.
Skinny hedgehog' (SKI1) encodes an enzyme that acts within the secretory pathway to catalyze amino-terminal palmitoylation of 'hedgehog' (see MIM 600725).
protein-cysteine N-palmitoyltransferase HHAT
, hedgehog acyltransferase
, protein-cysteine N-palmitoyltransferase HHAT-like
, melanoma antigen recognized by T cells 2
, melanoma antigen recognized by T-cells 2
, skinny hedgehog protein 1
, skinny hedgehog protein