You are viewing an incomplete version of our website. Please click to reload the website as full version.

Browse our Protein Kinase, CAMP-Dependent, Regulatory, Type II, alpha Proteins (PRKAR2A)

Full name:
Protein Kinase, CAMP-Dependent, Regulatory, Type II, alpha Proteins (PRKAR2A)
On www.antibodies-online.com are 8 Protein Kinase, CAMP-Dependent, Regulatory, Type II, alpha (PRKAR2A) Proteins from 4 different suppliers available. Additionally we are shipping Protein Kinase, CAMP-Dependent, Regulatory, Type II, alpha Antibodies (62) and many more products for this protein. A total of 74 Protein Kinase, CAMP-Dependent, Regulatory, Type II, alpha products are currently listed.
Synonyms:
1110061A24Rik, AI317181, AI836829, PKR2, PRKAR2, PRKAR2A, RII(alpha), zgc:85886
list all proteins Gene Name GeneID UniProt
PRKAR2A 29699 P12368
PRKAR2A 19087  
PRKAR2A 5576 P13861

Show all synonyms

Protein Kinase, CAMP-Dependent, Regulatory, Type II, alpha Proteins (PRKAR2A) by Origin

Select your origin of interest

More Proteins for Protein Kinase, CAMP-Dependent, Regulatory, Type II, alpha Interaction Partners

Mouse (Murine) Protein Kinase, CAMP-Dependent, Regulatory, Type II, alpha (PRKAR2A) interaction partners

  1. Results show that mouse Prkar1a (show PRKAR1A Proteins) and human PRKAR2A exhibited a dynamic spatio-temporal expression in tooth development, whereas neither human PRKAR1A (show PRKAR1A Proteins) nor mouse Prkar2a showed their expression in odontogenesis.

  2. Results indicte that Cypher/ZASP (show LDB3 Proteins) interacted with the regulatory subunit RIIalpha of PKA.

  3. a key role for AKAP-targeted PKA in control of heart rate and contractile function

  4. The RII alpha regulatory subunit of protein kinase A is not required for normal T cell development, homeostasis, and the generation of a cell-mediated immune response in vivo.

  5. The high-resolution crystal structures of the docking and dimerization (D/D) domain of the RIIalpha regulatory subunit of PKA in complex with the high-affinity anchoring peptide AKAP-IS explain the molecular basis for AKAP-regulatory subunit recognition.

  6. crystal structure of RIIalpha holoenzyme solved and compared to the RIalpha (show PRKAR1A Proteins) holoenzyme; structure demonstrates the conserved and isoform-specific features of RI and RII and the importance of ATP

  7. AKAP121 (show AKAP1 Proteins) and PKAR2A serve to enhance steroidogenesis by directing the synthesis and activation of STAR at the mitochondria in response to cAMP.

  8. protein kinase cAMP dependent regulatory type II alpha showed a clear-cut double striation pattern on each m-line and z-line.

Human Protein Kinase, CAMP-Dependent, Regulatory, Type II, alpha (PRKAR2A) interaction partners

  1. High PK-R2 (show PROKR2 Proteins) expression is associated with colorectal cancer.

  2. Prkar2a deficiency predisposes to hematopoietic malignancies in vivo. RIIalpha's likely association with HS and DLBCL was hitherto unrecognized and may lead to better understanding of these rare neoplasms.

  3. Disruption of Snapin (show SNAPIN Proteins)-PKR2 (show PROKR2 Proteins) interaction did not affect PKR2 (show PROKR2 Proteins) signaling, but increased the ligand-induced degradation, implying a role of Snapin (show SNAPIN Proteins) in the trafficking of PKR2 (show PROKR2 Proteins).

  4. we demonstrate that neurochondrin has strong isoform selectivity towards the RIIa subunit of PKA with nanomolar affinity

  5. Results show that mouse Prkar1a (show PRKAR1A Proteins) and human PRKAR2A exhibited a dynamic spatio-temporal expression in tooth development, whereas neither human PRKAR1A (show PRKAR1A Proteins) nor mouse Prkar2a showed their expression in odontogenesis.

  6. These data demonstrate that some Kallmann syndrome-associated, intracellularly retained mutant PKR2 (show PROKR2 Proteins) receptors can be functionally rescued, suggesting a potential treatment strategy for patients bearing such mutations.

  7. while there is no change in type II regulatory (RIIalpha) or catalytic (Calpha (show PRKACA Proteins)) subunit expression, site specific RIIalpha (Ser96) and Calpha (show PRKACA Proteins) (Thr197) phosphorylation are increased in heart failure, as well as expression of type I regulatory subunit (RI)

  8. Smad4 (show SMAD4 Proteins) and the R subunit of the protein kinase A holoenzyme form a functional complex in vivo in response to TGFbeta (show TGFB1 Proteins).

  9. ETO nervy homology region (NHR) 3 domain-PKA(RIIalpha) protein interaction does not appear to significantly contribute to AML1-ETO's ability to induce leukemia.

  10. These data implicate the involvement of PKA-RIIalpha anchoring apical targeting of distinct proteins and glycosphingolipids to apical plasma membrane domains and suggest that rerouting may underlie the delayed Golgi-to-apical surface transport of MDR1.

Cow (Bovine) Protein Kinase, CAMP-Dependent, Regulatory, Type II, alpha (PRKAR2A) interaction partners

  1. angle X-ray scattering studies indicate RIalpha (show PRKAR1A Proteins), RIIalpha, and RIIbeta (show PRKAR2B Proteins) homodimers differ markedly in overall shape despite extensive sequence homology and similar molecular masses;cAMP binding does not cause large conformational changes(Prkar1a (show PRKAR1A Proteins), Prkar2a)

Pig (Porcine) Protein Kinase, CAMP-Dependent, Regulatory, Type II, alpha (PRKAR2A) interaction partners

Protein Kinase, CAMP-Dependent, Regulatory, Type II, alpha (PRKAR2A) Protein Profile

Protein Summary

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER).

Alternative names and synonyms associated with Protein Kinase, CAMP-Dependent, Regulatory, Type II, alpha (PRKAR2A)

  • protein kinase, cAMP-dependent, regulatory, type II, alpha, B (prkar2ab)
  • solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 (SLC25A20)
  • protein kinase, cAMP-dependent, regulatory, type II, alpha (PRKAR2A)
  • protein kinase, cAMP-dependent, regulatory, type II, alpha (LOC100221642)
  • protein kinase, cAMP dependent regulatory, type II alpha (Prkar2a)
  • 1110061A24Rik protein
  • AI317181 protein
  • AI836829 protein
  • PKR2 protein
  • PRKAR2 protein
  • PRKAR2A protein
  • RII(alpha) protein
  • zgc:85886 protein

Protein level used designations for PRKAR2A

protein kinase, cAMP-dependent, regulatory, type II, alpha , carnitine/acylcarnitine translocase , cAMP-dependent protein kinase type II-alpha regulatory subunit-like , cAMP-dependent protein kinase type II-alpha regulatory subunit , protein kinase cAMP-dependent regulatory type II alpha , protein kinase, cAMP-dependent, regulatory, type 2, alpha , cAMP-dependent protein kinase regulatory subunit RII alpha , protein kinase A, RII-alpha subunit , cAMP-dependent protein kinase, regulatory subunit alpha 2

GENE ID SPECIES
405894 Danio rerio
416062 Gallus gallus
484774 Canis lupus familiaris
708872 Macaca mulatta
100221642 Taeniopygia guttata
100415419 Callithrix jacchus
100596033 Nomascus leucogenys
29699 Rattus norvegicus
19087 Mus musculus
5576 Homo sapiens
518399 Bos taurus
100685147 Canis lupus familiaris
397493 Sus scrofa
100139910 Bos taurus
Selected quality suppliers for Protein Kinase, CAMP-Dependent, Regulatory, Type II, alpha Proteins (PRKAR2A)
Did you look for something else?