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a significant association between PKR2 rs6053283 polymorphism and Recurrent pregnancy loss (RPL) (P=0.003), whereas no association was observed between PKR1 rs4627609 polymorphism and RPL (P=0.929) in the Chinese Han population.
Data suggest that prokineticins (PROK1 (show Prok1 Proteins) and PROK2 (show PROK2 Proteins)) and prokineticin receptors (PROKR1 (show PROKR1 Proteins) and PROKR2) act as main regulators of physiological functions of ovary, uterus, placenta, and testis. [REVIEW]
High PK-R2 expression is associated with colorectal cancer.
PROKR2 may play a role in susceptibility of pituitary stalk interruption syndrome
Prkar2a (show PRKAR2A Proteins) deficiency predisposes to hematopoietic malignancies in vivo. RIIalpha's likely association with HS and DLBCL was hitherto unrecognized and may lead to better understanding of these rare neoplasms.
Disruption of Snapin (show SNAPIN Proteins)-PKR2 interaction did not affect PKR2 signaling, but increased the ligand-induced degradation, implying a role of Snapin (show SNAPIN Proteins) in the trafficking of PKR2.
we demonstrate that neurochondrin has strong isoform selectivity towards the RIIa subunit of PKA with nanomolar affinity
PROKR2 expression in human fetal ovary remained unchanged throughout gestation.
EG-VEGF (show Prok1 Proteins), BV8 (show PROK2 Proteins), and PROKR2 gene expression is approximately five, four, and two times higher in cystic fibrosis (show S100A8 Proteins) lungs compared with controls.
PKR2 protomers form type II dimers involving TMs (show TYMS Proteins) 4 and 5, with a role for TM5 in modulation of PKR2 function.
This study presents the first experimental evidence indicating a molecular interaction between anosmin 1 (show KAL1 Proteins) and PKR2. A truncated anosmin 1 (show KAL1 Proteins) protein comprising the first three domains of the protein interacts with the second extracellular loop of PKR2, involved in PK2 (show PROK2 Proteins) binding.
Data show that the prokineticins and their receptors PROK2 (show PROK2 Proteins), PKR1 (show PROKR1 Proteins) and PKR2 contributes to altered sensitivity in diabetic neuropathy and its inhibition blocked both allodynia and inflammatory events underlying disease.
Studies indicate PK2 (show PROK2 Proteins) signaling is required for the maintenance of normal female estrous cycles.
We sought to clarify the role of PROKR2 in hypothalamopituitary development through analysis of Prokr2(-/-) mice.
Prokr2 is specifically expressed in the XY gonads during sex determination and fetal sexual differentiation, and knockout mice display a variable degree of compromised vasculature in the fetal testes
The functional characteristics of coronary endothelial cells depend on the expression of PKR1 (show PROKR1 Proteins) and PKR2 levels and the divergent signaling pathways used by these receptors.
prokineticin 2 (show PROK2 Proteins) is expressed in neurons of the mouse suprachiasmatic nucleus
Phenotypic analysis indicated that not Pkr1 (show PROKR1 Proteins)(-/-)but Pkr2(-/-)mice exhibited hypoplasia of the olfactory bulb.
PKR2 expression was maintained over 10.5dpc with both trophoblastic and endothelial cell localisations in mice.
Important role for Prokr2 in olfactory bulb neurogenesis.
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER).
prokineticin receptor 2
, prokineticin receptor 2-like
, G protein-coupled receptor 73-like 1
, G-protein coupled receptor 73-like 1
, G protein-coupled receptor I5E
, G-protein coupled receptor I5E
, cAMP-dependent protein kinase regulatory subunit RII alpha
, cAMP-dependent protein kinase type II-alpha regulatory subunit
, protein kinase A, RII-alpha subunit