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The authors found that TRIM28 regulates alpha-Synuclein and tau nuclear levels and that its reduction rescues toxicity in animal models of tau- and alpha-Synuclein-mediated degeneration.
TRIM28 represses Endogenous retroviruses and consequently regulates the expression of neighboring genes.
it is primarily peroxide-induced p38 MAPK (show MAPK14 ELISA Kits) that mediates Ser473 phosphorylation and activation of TIF1beta to enable more efficient DNA repair to assist in tumor cell survival against exogenous ROS (show ROS1 ELISA Kits)
TRIM28 acts as a central factor in controlling endothelial inflammatory responses and angiogenic activities by retaining expression of TNFR-1 (show TNFRSF1A ELISA Kits) and -2 and VEGF receptor 2 in endothelial cells
TRIM28 depletion repressed EZH2 (show EZH2 ELISA Kits) recruitment to chromatin and expression of this gene set, in parallel with decreased CD44 (show CD44 ELISA Kits)(hi)/CD24 (show CD24 ELISA Kits)(lo) mammosphere formation.
These findings provide a unique context in which ataxia telangiectasia mutated (show ATM ELISA Kits) proteins modify KAP1 (show CDKN3 ELISA Kits) to regulate persistence of a herpesvirus in humans
our results suggest that KAP1 (show CDKN3 ELISA Kits) Ser473 phosphorylation acts through MFN2 (show MFN2 ELISA Kits) reduction to restrict mitochondrial hyperfusion, thereby contributing to cancer cell survival under conditions of sustained metabolic stress
OGA (show MGEA5 ELISA Kits) is physically associated with the known RNA polymerase II (pol II) pausing/elongation factors SPT5 (show SUPT5H ELISA Kits) and TRIM28-KAP1-TIF1beta, and a purified OGA (show MGEA5 ELISA Kits)-SPT5 (show SUPT5H ELISA Kits)-TIF1beta complex has elongation properties.
that KAP1 phosphorylation is decreased following recruitment of PP2A by URI.
Taken together, these results suggest that PARIS and PIASy (show PIAS4 ELISA Kits) modulate PGC (show PGC ELISA Kits)-1a gene transcription through distinct molecular mechanisms.
Nuclear factors that bind to genomic regions with "Sertoli Cell Signature" could functionally interact with SOX9 (show SOX9 ELISA Kits); TRIM28 is a new SOX9 (show SOX9 ELISA Kits) partner in fetal testes.
TRIM28 safeguards germline-to-soma inheritance of epigenetic features at other genomic regions in an exquisitely stage-dependent manner.
Data suggest that TRIM28 regulates the expression of a subset of lncRNAs.
Zygotic TRIM28 is essential for genomic imprinting. Secondary imprints were hypomethylated in TRIM28 mutants.
Trim28(+/D9) mutant mice exhibit a bi-modal body-weight distribution, with isogenic animals randomly emerging as either normal or obese and few intermediates.
Data suggest that interaction between KAP1 and the KRAB A box of zinc finger protein 809 (ZFP809) is critical in KAP1-dependent control of gene silencing for ZFP809 targets.
We find that NPCs use TRIM28-mediated histone modifications to dynamically regulate transcription and silencing of ERVs, which is in contrast to other somatic cell types using DNA methylation (show HELLS ELISA Kits)
WTX (show AMER1 ELISA Kits) stabilized chromatin binding by TRIM28 and contributed to transcriptional repression of repetitive sequences by TRIM28 in mouse embryonic stem cells.
KAP-1 may contribute to the repression of Ey and beta-major globin gene transcription through recruitment to the promoters of these two genes, mediated by the interaction of KAP-1 with either Zfp445 or MafK, respectively
the TIF1beta-HP1 (show CBX5 ELISA Kits) system functions as a critical repressive machinery that targets genes not normally activated in the hematopoietic compartment, thereby maintaining the transcriptional signature specific to HSCs.
The protein encoded by this gene mediates transcriptional control by interaction with the Kruppel-associated box repression domain found in many transcription factors. The protein localizes to the nucleus and is thought to associate with specific chromatin regions. The protein is a member of the tripartite motif family. This tripartite motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region.
E3 SUMO-protein ligase TRIM28
, KRAB-associated protein 1
, KRAB-interacting protein 1
, RING finger protein 96
, nuclear corepressor KAP-1
, transcription intermediary factor 1-beta
, transcriptional intermediary factor 1-beta
, tripartite motif-containing 28
, tripartite motif-containing protein 28
, transcription intermediary factor 1-beta-like
, KRAB-A-interacting protein
, transcriptional intermediary factor 1, beta
, tripartite motif protein 28
, TIF1beta transcription factor