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Heme-Regulated eIF2alpha (show EIF2A ELISA Kits) Kinase Modulates Hepatic FGF21 (show FGF21 ELISA Kits) and Is Activated by PPARbeta (show PPARD ELISA Kits)/delta Deficiency. Findings suggest that HRI is a potential target for regulating hepatic FGF21 (show FGF21 ELISA Kits) levels.
These findings indicate that the anti-proliferative actions of PKR (show EIF2AK2 ELISA Kits) on pancreatic beta-cells may contribute to the pathogenesis of type 2 diabetes.
eukaryotic initiation factor 2alpha kinase is a protagonist of heme-mediated translational control of CYP2B enzymes and a modulator of basal endoplasmic reticulum stress tone.
HRI has an essential role in mediating arsenite stress-induced phosphorylation of eukaryotic translation initiation factor 2alpha (show EIF2S1 ELISA Kits), inhibition of protein synthesis, stress granule formation, and survival
Study of the kinetics showed that the heme-regulated inhibitor (HRI) kinase reaction follows classical Michaelis-Menten kinetics with respect to ATP but sigmoidal kinetics and positive cooperativity with respect to the protein substrate.
Results demonstrate that heme-regulated eIF2alpha (show EIF2A ELISA Kits) kinase deficiency attenuates hepcidin (show HAMP ELISA Kits) expression and iron homeostasis in mice, indicating a potential role for HRI in the anemia of inflammation.
heme-regulated eIF2alpha (show EIF2A ELISA Kits) kinase deficiency exacerbates decreases in hepcidin (show HAMP ELISA Kits) expression and splenic macrophage iron in HFE (show HFE ELISA Kits)(-)(/)(-) mice
The anti-viral properties of eIF2alpha (show EIF2A ELISA Kits) kinases are not always related to their inhibitory effects on host protein synthesis as previously thought and are possibly mediated by phosphorylation of proteins other than eIF2alpha (show EIF2A ELISA Kits).
The antiviral kinase PKR (show PKLR ELISA Kits) plays a critical role in controlling HCMV replication.
structural and functional stability of HRI
Infection-associated functions of HRI (an eIF2alpha (show EIF2A ELISA Kits) kinase) are independent of its activity as a regulator of protein synthesis.
During lead-stress, the regulation of hHRI mRNA translation is mediated through its 5'-untranslated region (UTR (show UTS2R ELISA Kits)) that interacts with specific trans-acting factors.
Dephosphorylation of eIF2alpha (show EIF2A ELISA Kits), specifically in the cortex, is both correlated with and necessary for normal memory consolidation.
autophosphorylation of Thr485 is essential for the hyperphosphorylation and activation of HRI and is required for the acquisition of the eIF2alpha (show EIF2A ELISA Kits) kinase activity
the inherent structural stability of HRI (KD)
The protein encoded by this gene acts at the level of translation initiation to downregulate protein synthesis in response to stress. The encoded protein is a kinase that can be inactivated by hemin. Two transcript variants encoding different isoforms have been found for this gene.
eukaryotic translation initiation factor 2-alpha kinase 1
, eukaryotic translation initiation factor 2 alpha kinase 1
, eIF 2a kinase
, heme-controlled repressor
, heme-regulated eukaryotic initiation factor eIF-2-alpha kinase
, heme-regulated inhibitor
, hemin-sensitive initiation factor 2-alpha kinase
, hemin-sensitive initiation factor 2a kinase
, heme regulated initiation factor 2 alpha kinase
, heme sensitive initiation factor 2a kinase
, heme-regulated initiation factor 2-alpha kinase
, heme-regulated repressor
, eukaryotic initiation factor 2 alpha kinase
, heme-regulated eIF-2a kinase