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Browse our anti-LDLR (LDLR) Antibodies

Full name:
anti-Low Density Lipoprotein Receptor Antibodies (LDLR)
On www.antibodies-online.com are 257 Low Density Lipoprotein Receptor (LDLR) Antibodies from 24 different suppliers available. Additionally we are shipping LDLR Kits (49) and LDLR Proteins (34) and many more products for this protein. A total of 348 LDLR products are currently listed.
Synonyms:
FH, FHC, Hlb301, LDLA, LDLCQ2, LDLRA

Most Popular Reactivities for anti-LDLR (LDLR) Antibodies

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anti-Human LDLR Antibodies:

anti-Mouse (Murine) LDLR Antibodies:

anti-Rat (Rattus) LDLR Antibodies:

All available anti-LDLR Antibodies

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Top referenced anti-LDLR Antibodies

  1. Cow (Bovine) Polyclonal LDLR Primary Antibody for WB - ABIN223504 : Dong, Wu, Li, Kraemer, Adeli, Seidah, Park, Liu: Strong induction of PCSK9 gene expression through HNF1{alpha} and SREBP2: Mechanism for the resistance to LDL-cholesterol lowering effect of statins in dyslipidemic hamsters. in Journal of lipid research 2010 (PubMed)
    Show all 7 references for ABIN223504

  2. Human Polyclonal LDLR Primary Antibody for IF (p), IHC (p) - ABIN672111 : Wu, He, Wang, Xue, Ning, Zou, Ye, Li, Wang, Pang: The antihypercholesterolemic effect of jatrorrhizine isolated from Rhizoma Coptidis. in Phytomedicine : international journal of phytotherapy and phytopharmacology 2014 (PubMed)
    Show all 4 references for ABIN672111

  3. Human Monoclonal LDLR Primary Antibody for ELISA (Capture), FACS - ABIN4899696 : Boucrot, Ferreira, Almeida-Souza, Debard, Vallis, Howard, Bertot, Sauvonnet, McMahon: Endophilin marks and controls a clathrin-independent endocytic pathway. in Nature 2015 (PubMed)
    Show all 3 references for ABIN4899696

  4. Human Polyclonal LDLR Primary Antibody for ICC, IF - ABIN438622 : Wang, Gao, Liao, Qi, Du, Wang, Li, Liu, Yang: Adipose tissue deficiency results in severe hyperlipidemia and atherosclerosis in the low-density lipoprotein receptor knockout mice. in Biochimica et biophysica acta 2016 (PubMed)
    Show all 3 references for ABIN438622

  5. Human Monoclonal LDLR Primary Antibody for FACS - ABIN4896539 : Le, Blanchet, Seidah, Labonté: Plasma Membrane Tetraspanin CD81 Complexes with Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) and Low Density Lipoprotein Receptor (LDLR), and Its Levels Are Reduced by PCSK9. in The Journal of biological chemistry 2015 (PubMed)
    Show all 3 references for ABIN4896539

  6. Human Monoclonal LDLR Primary Antibody for FACS - ABIN4896543 : Ramanathan, Gusarova, Stahl, Gurnett-Bander, Kyratsous: Alirocumab, a Therapeutic Human Antibody to PCSK9, Does Not Affect CD81 Levels or Hepatitis C Virus Entry and Replication into Hepatocytes. in PLoS ONE 2016 (PubMed)
    Show all 3 references for ABIN4896543

  7. Mouse (Murine) Polyclonal LDLR Primary Antibody for FACS, ICC - ABIN4899698 : Seidah, Poirier, Denis, Parker, Miao, Mapelli, Prat, Wassef, Davignon, Hajjar, Mayer: Annexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradation. in PLoS ONE 2012 (PubMed)

  8. Human Polyclonal LDLR Primary Antibody for EIA, IHC (p) - ABIN500146 : Li, Cam, Bu: Low-density lipoprotein receptor family: endocytosis and signal transduction. in Molecular neurobiology 2001 (PubMed)

  9. Human Polyclonal LDLR Primary Antibody for FACS, WB - ABIN652907 : Brown, Goldstein: Receptor-mediated endocytosis: insights from the lipoprotein receptor system. in Proceedings of the National Academy of Sciences of the United States of America 1979 (PubMed)

  10. Mouse (Murine) Monoclonal LDLR Primary Antibody for FACS, WB - ABIN4899699 : Rousselet, Marcinkiewicz, Kriz, Zhou, Hatten, Prat, Seidah: PCSK9 reduces the protein levels of the LDL receptor in mouse brain during development and after ischemic stroke. in Journal of lipid research 2011 (PubMed)

More Antibodies against LDLR Interaction Partners

Human Low Density Lipoprotein Receptor (LDLR) interaction partners

  1. LDLR mutation is associated in children and adolescent with familial hypercholesterolemia.

  2. Even though LDLR-R410S and LDLR-WT were similar in levels of cell surface and total receptor and bound equally well to LDL or extracellular PCSK9 (show PCSK9 Antibodies), the LDLR-R410S was resistant to exogenous PCSK9 (show PCSK9 Antibodies)-mediated degradation in endosomes/lysosomes and showed reduced LDL internalization and degradation relative to LDLR-WT.

  3. study provides the first evidence that GPC3 (show GPC3 Antibodies) can modulate the PCSK9 (show PCSK9 Antibodies) extracellular activity as a competitive binding partner to the LDLR in HepG2 cells.

  4. ox-LDL play a role in the pathogenesis of AMD (show AMD1 Antibodies) by NLRP3 (show NLRP3 Antibodies) inflammasome activation. Suppression of NLRP3 (show NLRP3 Antibodies) inflammasome activation could attenuate RPE (show RPE Antibodies) degeneration and AMD (show AMD1 Antibodies) progression.

  5. Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9 (show PCSK9 Antibodies)) Single Domain Antibodies Are Potent Inhibitors of Low Density Lipoprotein Receptor Degradation.

  6. This study demonstrated that IL-2 (show IL2 Antibodies) and IL-10 (show IL10 Antibodies) were related to gene polymorphisms of LDL-R, which might be involved in the development and progress of hypercholesterolemia.

  7. Lipoprotein profiles get improved by liver-directed gene transfer of human LDLR gene in hypercholesterolaemia mice.

  8. Multiple novel LDLR and ApoB (show APOB Antibodies) mutations have been identified in a-United Kingdom-based cohort with familial hypercholesterolemia.

  9. Mutations in LDLR is associated with coronary artery disease.

  10. LDLR A(+)A(+) genotype, ApoB (show APOB Antibodies) X(+) allele and ApoE (show APOE Antibodies) E4 allele increased the risk of premature coronary artery disease by 1.8, 2.1 and 12.1 respectively.

Cow (Bovine) Low Density Lipoprotein Receptor (LDLR) interaction partners

  1. Nonesterified fatty acids significantly inhibit the expression of ApoB100 (show APOB Antibodies), ApoE (show APOE Antibodies), MTP (show MTTP Antibodies), and LDLR, thereby decreasing the synthesis and assembly of VLDL and inducing TG accumulation in bovine hepatocytes.

Mouse (Murine) Low Density Lipoprotein Receptor (LDLR) interaction partners

  1. Cyclosporin A does not cause hyperlipidemia via direct effects on the LDLr. Rather, LDLr deficiency plays an important permissive role for CsA (show HSPA9 Antibodies)-induced hyperlipidemia, which is associated with abnormal lipoprotein clearance, decreased lipoprotein lipase (show LPL Antibodies) activity, and increased levels of apolipoprotein C-III (show APOC3 Antibodies) and proprotein convertase subtilisin/kexin type 9 (show PCSK9 Antibodies).

  2. Ldlr(-/-) Creb3l3 (show CREB3L3 Antibodies)(-/-) mice developed significantly more atherosclerotic lesions in the aortas than Ldlr(-/-) mice.

  3. Loss of Jnk1 (show MAPK8 Antibodies), but not Jnk2 (show MAPK9 Antibodies), in macrophages protects them from apoptosis, increasing cell survival, and this accelerates early atherosclerosis in LDL receptor knockout mice.

  4. ATP-citrate lyase (show ACLY Antibodies) inhibitor bempedoic acid effectively prevents plasma and tissue lipid elevations and attenuates the onset of inflammation, leading to the prevention of atherosclerotic lesion development in a Ldlr knockout mouse model of metabolic dysregulation.

  5. Increased colonization of the disease-protective gut (show GUSB Antibodies) bacteria Akkermansia muciniphila protected the host from acute and chronic hyperlipidemia by enhancing the low-density lipoprotein receptor expression and alleviating hepatic endoplasmic reticulum stress and the inflammatory response in CREBH (show CREB3L3 Antibodies)-null mice.

  6. These data indicate that serum amyloid A (SAA)regulates the level of bone marrow monocytes and their myeloid progenitors in hyperlipidemic Ldlr(-/-) mice.

  7. Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9 (show PCSK9 Antibodies)) Single Domain Antibodies Are Potent Inhibitors of Low Density Lipoprotein Receptor Degradation.

  8. Ldlr knockout mice had smaller litter sizes than wild type. KO mice had higher serum cholesterol level, and decreased cholesterol, triglycerides and total lipids in ovary. KO mice had fewer ovarian follicles, lower estrogen levels and impaired estrous cycles and ovulation than wild type mice.

  9. These data strongly imply that LDLr significantly contributes to beta-carotene uptake in the adult mouse liver. In contrast, LDLr does not seem to mediate acquisition of beta-carotene by the placental-fetal unit.

  10. The values in the Apoe (show APOE Antibodies)-deficient mice were much greater than in the Ldlr mice. These findings suggest that Apoe (show APOE Antibodies)-deficient mice showed increased susceptibility to inflammation-associated colorectal carcinogenesis due to their high reactivity to inflammatory stimuli.

Pig (Porcine) Low Density Lipoprotein Receptor (LDLR) interaction partners

  1. The LDLR gene should be a candidate causative gene for LDL-cholesterol and total cholesterol in pigs, but heterogeneity exists in different populations.

  2. KLF13 (show KLF13 Antibodies) and SREBP-Sp1 (show SP1 Antibodies) activation interact to regulate low density lipoprotein receptor promoter function

  3. found association between genotypes for LDLR and APOB (show APOB Antibodies) polymorphisms and serum lipid levels, but none of them seem to be the causal mutation but probably represent closely linked polymorphisms

LDLR Antigen Profile

Antigen Summary

The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.

Alternative names and synonyms associated with LDLR

  • low density lipoprotein receptor (ldlr) antibody
  • low density lipoprotein receptor (LDLR) antibody
  • low density lipoprotein receptor (Ldlr) antibody
  • low density protein receptor (LOC443535) antibody
  • FH antibody
  • FHC antibody
  • Hlb301 antibody
  • LDLA antibody
  • LDLCQ2 antibody
  • LDLRA antibody

Protein level used designations for LDLR

low-density lipoprotein receptor , LDL receptor , low-density lipoprotein receptor class A domain-containing protein 3 , low density lipoprotein receptor (familial hypercholesterolemia)

GENE ID SPECIES
387529 Danio rerio
3949 Homo sapiens
281276 Bos taurus
100009086 Oryctolagus cuniculus
16835 Mus musculus
300438 Rattus norvegicus
100724238 Cavia porcellus
396801 Sus scrofa
100683160 Canis lupus familiaris
395103 Gallus gallus
100689399 Cricetulus griseus
443535 Ovis aries
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