Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all synonyms
Oas1b is part of a complex located in the ER and that ABCF3 is a component of the Flv(r)-mediated resistance mechanism.
Activation of Oas1b gene expression by type I IFN requires only STAT2 (show STAT2 ELISA Kits), not STAT1 (show STAT1 ELISA Kits).
Oas1b inhibits flavivirus replication by an alternative mechanism that overrides the proviral effect of reducing 2-5A accumulation and RNase L (show RNASEL ELISA Kits) activation.
A positional cloning strategy was used to identify 22 genes from the Flv gene interval including 10 members of the 2'-5'-oligoadenylate synthetase gene family.
This gene is a member of the 2'-5' oligoA synthetase family, which are clustered on chromosome 5. The encoded protein functions in the interferon-regulated OAS/RNase L system, which mediates RNA decay as part of the innate antiviral immunity pathway. The protein binds double-stranded RNA and oligomerizes ATP, which activate the single-stranded RNA cleavage enzyme RNase L. This protein mediates resistance to flaviviruses such as West Nile virus. The majority of wild mouse strains produce a functional protein and are resistant to flavivirus infection, whereas some inbred mouse strains including the strain of the reference genome, C57BL/6J, contain a premature stop codon that inactivates this gene product.
(2-5')oligo(A) synthase 1B
, (2-5')oligo(A) synthetase 1b
, 2',5'-oligoadenylate synthetase-like 1
, 2'-5'-oligoadenylate synthase 1B
, 2'-5'-oligoadenylate synthase-like protein 1
, 2'-5'-oligoadenylate synthetase-like protein 1
, 2-5A synthase 1B
, 2-5A synthetase 1B
, Flavivirus resistance
, inactive 2'-5'-oligoadenylate synthase 1B