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Browse our DIO1 Proteins (DIO1)

Full name:
Deiodinase, Iodothyronine, Type I Proteins (DIO1)
On are 7 Deiodinase, Iodothyronine, Type I (DIO1) Proteins from 4 different suppliers available. Additionally we are shipping DIO1 Antibodies (26) and DIO1 Kits (17) and many more products for this protein. A total of 51 DIO1 products are currently listed.
list all proteins Gene Name GeneID UniProt
DIO1 1733 P49895
DIO1 13370 Q61153
DIO1 25430 P24389

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Human Deiodinase, Iodothyronine, Type I (DIO1) interaction partners

  1. The DIO1 (show DIDO1 Proteins) gene is related to the depression.

  2. Functional variants within the DIO1 (show DIDO1 Proteins) gene that affect triiodothyronine (T3) levels seem not to be associated with cognitive functions.

  3. All these results indicate that the oxidative stress downregulates the conversion of T4 to T3 through DIO1 (show DIDO1 Proteins) function in HepG2 cells.

  4. Thyroid hormone (show PTH Proteins) deiodinases D1, D2, and D3 are differentially expressed in endothelial cells following thyroid hormone (show PTH Proteins) exposure.

  5. The pattern of expression and role of triiodothyronine (T3) receptors and type I 5'-deiodinase in breast carcinomas, benign breast diseases, lactational change, and normal breast epithelium.

  6. [review] Deiodinase type 1 polymorphisms particularly show moderate-to-strong relationships with thyroid hormone (show PTH Proteins) parameters, insulin (show INS Proteins)-like growth factor (IGF)1 (show IGF1 Proteins) protein production, and risk for depression.

  7. a new mechanism of posttranscriptional regulation of DIO1 (show DIDO1 Proteins) and show deregulation of DIO1 (show DIDO1 Proteins) expression in pituitary adenoma, possibly resulting from disturbed expression of SF2/ASF (show SRSF1 Proteins).

  8. Data indicate that type 1 deiodinase is subject to catalysis-induced loss of activity.

  9. investigation of DIO1 (show DIDO1 Proteins) and DIO2 (show DIO2 Proteins) activities in 66 thyroid tissue samples from follicular thyroid adenoma, toxic diffuse goiter, nontoxic multinodular goiter, papillary thyroid carcinoma, and surrounding normal tissues

  10. Short interfering RNA-mediated knockdown of FOXA1 (show FOXA1 Proteins) decreased the expression of DIO1 (show DIDO1 Proteins) mRNA, but knockdown of both FOXA1 (show FOXA1 Proteins) and FOXA2 (show FOXA2 Proteins) restored it.

Mouse (Murine) Deiodinase, Iodothyronine, Type I (DIO1) interaction partners

  1. Reductions in Dio1 expression reduce the expression of ApoA-I (show APOA1 Proteins) in a 3,5,3'-triiodothyronine-/thyroid hormone (show PTH Proteins) response element-independent manner.

  2. Systemic changes in thyroid hormone (show PTH Proteins) economy as a result of acute food deprivation are not dependent on the deiodinases D1 or D2 but are mediated in part by sequestration of type4 and type3 in tissues and their enhanced metabolism by deiodinase D3.

  3. Results demonstrate changes in D1 activity in white adipose tissue under conditions of changing adiposity, and a stimulatory effect of leptin (show LEP Proteins) on D1 activity in the tissue.

  4. A decreased hepatic D1 activity could be the biochemical basis of some of the abnormal thyroid parameters observed in cystic fibrosis (show S100A8 Proteins)

  5. The type 1 deiodinase (D1) is an important source of Triiodothyronine in the euthyroid state.

  6. HNF4alpha (show HNF4A Proteins) regulates thyroid hormone (show PTH Proteins) homeostasis through transcriptional regulation of the Dio1 gene with GATA4 (show GATA4 Proteins) and KLF9 (show KLF9 Proteins)

Pig (Porcine) Deiodinase, Iodothyronine, Type I (DIO1) interaction partners

DIO1 Protein Profile

Protein Summary

The protein encoded by this gene is a thiol-requiring propylthiouracil-sensitive oxidoreductase. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It also degrades both hormones by inner ring deiodination (IRD). Alternative splicing results in multiple transcript variants encoding different isoforms. Some, but not all, isoforms contain a selenocysteine (Sec) residue encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Additional transcript variants have been described but are not supported by experimental evidence.

Alternative names and synonyms associated with DIO1

  • deiodinase, iodothyronine, type I (LOC100231867)
  • deiodinase, iodothyronine, type 1 (dio1)
  • deiodinase, iodothyronine, type I (DIO1)
  • deiodinase, iodothyronine, type I (Dio1)
  • 5DI protein
  • D1 protein
  • DIOI protein
  • ITDI1 protein
  • TXDI1 protein

Protein level used designations for DIO1

5DI , DIOI , deiodinase, iodothyronine, type I , type 1 DI , type 1 deiodinase , type I iodothyronine deiodinase , type-I 5'-deiodinase , thyroxine deiodinase type I (selenoprotein) , thyroxine deiodinase, type I , thyroxine deiodinase type 1 , Type 1 DI , Type-I 5'-deiodinase

100231867 Taeniopygia guttata
733447 Xenopus laevis
1733 Homo sapiens
13370 Mus musculus
25430 Rattus norvegicus
403635 Canis lupus familiaris
395940 Gallus gallus
414380 Sus scrofa
100101570 Oryctolagus cuniculus
493798 Felis catus
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