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wW observed that the DIO1 (show DIDO1 Proteins) rs2235544 SNP modified the association between exposure to some of the organochlorine compounds (OCs) (specifically HCB and PCB153) and maternal thyroid hormone (show PTH Proteins) levels. These results strengthen the hypothesis that the deiodinase enzymes play a role in explaining the disruption of thyroid hormones in relation to exposure to OCs.
data supports the notion that suppressed DIO1 (show DIDO1 Proteins) expression and changes in local availability of thyroid hormones might favor a shift from a differentiated to a more proliferation-prone state of cancer tissues and cell lines
evaluated the Death Inducer-Obliterator (DIDO) (variants DIDO 1 (show DIDO1 Proteins), 2 and 3) levels in CML (show BCR Proteins), PV, ET and PMF (show PRB1 Proteins) patients. Our data reported the DIDO 1 (show DIDO1 Proteins), 2 and 3 differential expressions in Myeloproliferative Neoplasms.
results indicated that LXRalpha (show NR1H3 Proteins) plays a specific and important role in activation of TH by regulating D1, and that LXRalpha (show NR1H3 Proteins) binds to and regulates the hDIO1 promoter, competing with TRbeta (show TXNRD2 Proteins) on specific sequences within the promoter.
The DIO1 (show DIDO1 Proteins) gene is related to the depression.
Functional variants within the DIO1 (show DIDO1 Proteins) gene that affect triiodothyronine (T3) levels seem not to be associated with cognitive functions.
All these results indicate that the oxidative stress downregulates the conversion of T4 to T3 through DIO1 (show DIDO1 Proteins) function in HepG2 cells.
Thyroid hormone (show PTH Proteins) deiodinases D1, D2, and D3 are differentially expressed in endothelial cells following thyroid hormone (show PTH Proteins) exposure.
The pattern of expression and role of triiodothyronine (T3) receptors and type I 5'-deiodinase in breast carcinomas, benign breast diseases, lactational change, and normal breast epithelium.
[review] Deiodinase type 1 polymorphisms particularly show moderate-to-strong relationships with thyroid hormone (show PTH Proteins) parameters, insulin (show INS Proteins)-like growth factor (IGF)1 (show IGF1 Proteins) protein production, and risk for depression.
Reductions in Dio1 expression reduce the expression of ApoA-I (show APOA1 Proteins) in a 3,5,3'-triiodothyronine-/thyroid hormone (show PTH Proteins) response element-independent manner.
Systemic changes in thyroid hormone (show PTH Proteins) economy as a result of acute food deprivation are not dependent on the deiodinases D1 or D2 but are mediated in part by sequestration of type4 and type3 in tissues and their enhanced metabolism by deiodinase D3.
Results demonstrate changes in D1 activity in white adipose tissue under conditions of changing adiposity, and a stimulatory effect of leptin (show LEP Proteins) on D1 activity in the tissue.
A decreased hepatic D1 activity could be the biochemical basis of some of the abnormal thyroid parameters observed in cystic fibrosis (show S100A8 Proteins)
The type 1 deiodinase (D1) is an important source of Triiodothyronine in the euthyroid state.
HNF4alpha (show HNF4A Proteins) regulates thyroid hormone (show PTH Proteins) homeostasis through transcriptional regulation of the Dio1 gene with GATA4 (show GATA4 Proteins) and KLF9 (show KLF9 Proteins)
This study investigated deiodinase 1 (Dio1), deiodinase 2 (Dio2 (show DIO2 Proteins)), and deiodinase 3 (Dio3 (show DIO3 Proteins)) mRNA expression at the several zebrafish life stages and found life stage specific expression of these genes that were highly localized.
Apoptosis, a major form of cell death, is an efficient mechanism for eliminating unwanted cells and is of central importance for development and homeostasis in metazoan animals. In mice, the death inducer-obliterator-1 gene is upregulated by apoptotic signals and encodes a cytoplasmic protein that translocates to the nucleus upon apoptotic signal activation. When overexpressed, the mouse protein induced apoptosis in cell lines growing in vitro. This gene is similar to the mouse gene and therefore is thought to be involved in apoptosis. Alternatively spliced transcripts have been found for this gene, encoding multiple isoforms.
, thyroxine deiodinase type I (selenoprotein)
, type 1 DI
, type I iodothyronine deiodinase
, type-I 5'-deiodinase
, death-associated transcription factor 1
, death-inducer obliterator 1
, thyroxine deiodinase, type I
, thyroxine deiodinase type 1
, Type 1 DI
, Type-I 5'-deiodinase
, deiodinase, iodothyronine, type I
, type 1 deiodinase