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IFN-epsilon is constitutively expressed by cells of the reproductive tract and is inefficiently secreted by fibroblasts and cell lines.
IFN-epsilon could promote migration of antigen-specific CD8 (show CD8A Proteins)(+)T cells to the gut (show GUSB Proteins).
Ifn-epsilon-deficient mice had increased susceptibility to infection of the female reproductive tract by the common sexually transmitted infections (STIs) herpes simplex virus 2 and Chlamydia muridarum.
The data suggest that TEAD relocation and/or YAP degradation following its phosphorylation down-regulates IFNT gene transcription after conceptus attachment to the uterine endometrium.
Report interferon-tau dependent STAT1 (show STAT1 Proteins) regulation of SOCS (show CISH Proteins) genes in bovine endometrium during estrus cycle and embryo implantation.
Suggest the involvement of IFNT function within the corpus luteum in the establishment of pregnancy in cows.
These results indicate that HB-EGF (show HBEGF Proteins) and its receptors expression changed in bovine endometrium throughout the oestrous cycle; IFN-tau increased their expression in cultured endometrial cells.
Data suggest exposure to maternal CSF2 (show CSF2 Proteins) from D5-D7 of development is fundamentally different for female/male blastocysts with respect to embryo elongation, characteristics of transcriptome/methylome, and endometrial interferon tau secretion at D15 (show MRPL16 Proteins).
as conceptuses attach to the uterine epithelium, IFNT gene transcription is down-regulated by an increase in EOMES (show EOMES Proteins) expression and EOMES (show EOMES Proteins)-CREBBP (show CREBBP Proteins) binding in the attached trophoblast cells.
Heat shock increased both HSP70 and IFNT expression in blastocysts.
In a cell culture experiment, interferon-tau stimulated stimulated IL-10 (show IL10 Proteins) mRNA expression in mononuclear leukocytes and tumor necrosis factor-alpha (show TNF Proteins) mRNA levels in neutrophils and eosinophils.
In contrast to previous studies in the ovine, granulocyte-macrophage colony-stimulating factor (show CSF2 Proteins) did not increase interferon tau secretion but in agreement with the ovine did not affect bovine blastocyst development.
Differentially expressed genes in the endometrial transcriptome are a consequence of IFNT production by the conceptus.
female sex workers decreased susceptibility to HIV-1 infection also have increased levels of IFNE gene and protein expression in the cervical epithelium
T Allele of nonsense polymorphism (rs2039381, Gln71Stop) of interferon-epsilon is a risk factor for the development of intracerebral hemorrhage.
Full-length IFN-epsilon 5'UTR markedly suppressed mRNA expression under basal conditions. It contains 2 stable stem-loop structures which associate with importin 9 (show IPO9 Proteins). Loop 1 is essential for regulation of mRNA expression.
genetic polymorphism is related to onset time of vitiligo (show MITF Proteins) in Korean patients
The structue and mRNA expression pattern of IFN-epsilon1 suggest that it may have a function distinct from those other members of type I INF (show GIF Proteins).
TNF-alpha (show TNF Proteins) leads to stabilization of IFN-epsilon mRNA, increased IFN-epsilon synthesis, engagement of type I IFNRs, increased STAT1 (show STAT1 Proteins) expression and phosphorylation, and up-regulation of retinoic acid-inducible gene-I (show DDX58 Proteins) expression
In macrophages IFN-tau increased the synthesis of 2',5'-oligoadenylate synthetase/RNase L (show RNASEL Proteins), MxA (show MX1 Proteins) protein, IL-10 (show IL10 Proteins) & IL-6 (show IL6 Proteins), but not of IL-1ss or TNF-alpha (show TNF Proteins).
Paracrine hormone primarily responsible for maternal recognition of pregnancy. Interacts with endometrial receptors, probably type I interferon receptors, and blocks estrogen receptor expression, preventing the estrogen-induced increase in oxytocin receptor expression in the endometrium. This results in the suppression of the pulsatile endometrial release of the luteolytic hormone prostaglandin F2-alpha, hindering the regression of the corpus luteum (luteolysis) and therefore a return to ovarian cyclicity. This, and a possible direct effect of IFN-tau on prostaglandin synthesis, leads in turn to continued ovarian progesterone secretion, which stimulates the secretion by the endometrium of the nutrients required for the growth of the conceptus. In summary, displays particularly high antiviral and antiproliferative potency concurrently with particular weak cytotoxicity, high antiluteolytic activity and immunomodulatory properties. In contrast with other IFNs, IFN-tau is not virally inducible.
, interferon epsilon 1
, interferon epsilon-1
, interferon tau-1
, interferon alpha II
, interferon tau-2
, interferon, trophoblast
, trophoblast antiluteolytic protein
, trophoblast protein 1
, trophoblast protein-1
, trophoblast type I interferon
, interferon epsilon
, Interferon tau-1
, Interferon tau-4