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Ovarian expression of relaxin-3a, d and f genes, and the relaxin-3 receptor gene Rxfp3 (show RXFP3 ELISA Kits), was studied in Danio rerio.
pattern indicates both conserved and divergent expression features of the relaxin-3 gene among developing zebrafish
we report the expression pattern of the duplicated zebrafish rln3b gene and compare it to the previously analyszd spatial expression pattern of the rln3a gene
In a population of acute HF patients, admission relaxin (show 0 ELISA Kits) serum levels were associated with clinical and echocardiographic markers of pulmonary hypertension, RV dysfunction, and overload, suggesting a role for circulating relaxin (show 0 ELISA Kits) as a biomarker in this setting.
the negatively charged transmembrane aspartate residue controls activation of the relaxin-3 receptor RXFP3 (show RXFP3 ELISA Kits)
Relaxin-3 is a high-efficacy agonist at RXFP4 (show RXFP4 ELISA Kits) with a comparable signal transduction profile to INSL5 (show INSL5 ELISA Kits).
Serum concentrations of relaxin (show 0 ELISA Kits) showed a positive association to duration of gestation among women with miscarriage but no association to duration of gestation among women with spontaneous onset of labour.
Review of research depicts the connection of relaxin-3 with phenomena such as feeding behavior, spatial memory, sleep/wake cycle or modulation of pituitary gland hormone secretion.
we demonstrated distinct patterns of signalling for H3 and H2 relaxin (show 0 ELISA Kits) and R3(BDelta23-27)R/I5 at the RXFP3 (show RXFP3 ELISA Kits) receptor
Glu141 and Asp145 of the RXFP3 (show RXFP3 ELISA Kits) interact with the highly conserved arginine residues of relaxin-3.
Mutant relaxin-3 shows a significant decrease in receptor-activation potency towards RXFP4 (show RXFP4 ELISA Kits).
Relaxin-2 (show RLN1 ELISA Kits) or relaxin-3 levels are not related to component traits in patients with diabetes.
metabolic syndrome is associated with increased serum relaxin-3 levels in women
Results indicate endogenous RLN3/RXFP3 (show RXFP3 ELISA Kits) signaling can modulate hippocampal-dependent spatial reference and working memory via effects on somatostatin (show SST ELISA Kits) interneurons, and further our knowledge of hippocampal cognitive processing
That endogenous relaxin-3-RXFP3 (show RXFP3 ELISA Kits) signalling is a powerful mediator of salt appetite in mice.
The present study compared the ability of relaxin-3 deficient (null mutation) and C57BL/6J wildtype littermate mice to entrain daily running wheel activity to timed food availability.
These findings are consistent with an earlier report of increased activity scores in rats acutely injected centrally with R3/I5, and further suggest a role for relaxin-3/RXFP3 (show RXFP3 ELISA Kits) signalling in promoting behavioural arousal.
These preliminary studies suggest an interaction between relaxin-3 and ventrolateral preoptic galanin (show GAL ELISA Kits) neurons that may contribute to the arousal-promoting action of relaxin-3.
Central injection of the RXFP3 (show RXFP3 ELISA Kits) agonists R3/I5 or H3 relaxin (show 0 ELISA Kits) (0.5 nmol, icv) did not alter chow consumption in satiated mice relative to vehicle controls, during the 60 min after treatment.
Relaxin-3 knockout mice exhibit mild anxiolytic characteristics relative to wild-type mice, suggesting that this peptide is involved in anxiety-related behavior.
These studies support a role for relaxin-3 signaling in the control of arousal and sleep/wakefulness, and identify the relaxin-3 KO mouse as a useful model to study this role further.
Data provide evidence for the conserved nature of RLN3/RXFP3 (show RXFP3 ELISA Kits) systems in mammalian brain and the ability of RLN3/RXFP3 (show RXFP3 ELISA Kits) signaling to modulate "behavioral state" and an array of circuits involved in arousal, stress, affect, and cognition.
results indicate that relaxin 3 transcription is activated via the cAMP-PKA pathway in the downstream of CRF-R1 (show CRHR1 ELISA Kits)
May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 (GPCR135) and relaxin-3 receptor-2 (GPCR142).
relaxin-like peptide locus B
, relaxin 3
, relaxin family locus C type 2
, relaxin family locus C type I
, insulin-like 7
, insulin-like peptide 7
, insulin-like peptide INSL7
, prorelaxin H3
, prorelaxin M3
, prorelaxin R3
, Prorelaxin H3