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Cynomolgus ACVR2B Protein expressed in Human Cells - ABIN2009777
Hildén, Tuuri, Erämaa, Ritvos: Expression of type II activin receptor genes during differentiation of human K562 cells and cDNA cloning of the human type IIB activin receptor. in Blood 1994
Show all 4 references for ABIN2009777
Human ACVR2B Protein expressed in Human Cells - ABIN2002394
Persson, Souchelnytskyi, Franzén, Miyazono, ten Dijke, Heldin: Transforming growth factor (TGF-beta)-specific signaling by chimeric TGF-beta type II receptor with intracellular domain of activin type IIB receptor. in The Journal of biological chemistry 1997
Show all 3 references for ABIN2002394
Mouse (Murine) ACVR2B Protein expressed in Human Cells - ABIN2007451
Matzuk, Bradley: Structure of the mouse activin receptor type II gene. in Biochemical and biophysical research communications 1992
Show all 3 references for ABIN2007451
Human ACVR2B Protein expressed in HEK-293 Cells - ABIN2180560
Attisano, Wrana, Montalvo, Massagué: Activation of signalling by the activin receptor complex. in Molecular and cellular biology 1996
ActRIIB mRNA but not protein was decreased in skeletal muscle of obese compared with lean animals.
TGF-beta (show TGFB1 Proteins) receptor mediated telomerase inhibition, telomere shortening and breast cancer cell senescence.(
ActR-IIB is expressed in male germ cells and Sertoli cells.
Activin A (show INHBA Proteins) inhibited signaling by BMP-6 (show BMP6 Proteins) and BMP-9 (show GDF2 Proteins) by competing for type 2 receptors ACVR2A (show ACVR2A Proteins) and ACVR2B.
We found that the AAAAA, AGGAG, and AGGGA haplotypes in ACVR2B were associated with susceptibility to Premature Ovarian Failure when they also had at least one CATAG haplotype in ADAMTS19.
miR (show MLXIP Proteins)-21 interacts directly with the 3'-untranslated region of ACVR2B mRNA. Mechanical stretch suppressed ACVR2B protein levels in periodontal ligament stem cells. Gain- and loss of function of ACVR2B mediated the osteogenic differentiation of PDLSCs.
Adenomyotic tissues express high levels of myostatin, follistatin, and activin type II receptors.
Activin type IIB receptors are clearly demonstrable throughout the adult human hypothalamus and basal forebrain.
After eccentric exercise, postmenopausal women not using hormone therapy (HT) expressed lower levels of ActRIIb while postmenopausal women using HT showed a heightened response.
The interaction between all five miRNAs and ACVR2B was verified by an in vitro assay.
Mutations in Activin A Receptor Type IIB were identified in 4 of the 47 patients (8.5%) with heterotaxy syndrome. Our results expand the mutation spectrum of monogenic heterotaxy syndrome with associated cardiac anomalies.
Roles in hindbrain and neural crest cell (NCC) patterning, in NCC derived pharyngeal arch cartilage and joint formation, and in tooth development.
Differential muscle hypertrophy is associated with satellite cell numbers and Akt (show AKT1 Proteins) pathway activation following activin type IIB receptor inhibition in Mtm1 (show MTM1 Proteins)
ActRIIB inhibition enhanced energy expenditure only at ambient temperature or in the cold, where nonshivering thermogenesis is minimal, suggesting that brown fat activation plays a prominent role in the metabolic actions of ActRIIB inhibition.
findings best fit a model in which BMP3 (show BMP3 Proteins), produced by mature bone cells, acts to reduce BMP signaling through Acvr2b in skeletal progenitor cells, limiting their differentiation to mature osteoblasts
Functional redundancy in osteoblast differentiation is observed between bone morphogenetic protein receptor BMPR-II (show BMPR2 Proteins) and ActR-IIB.
Inhibition of activin receptor type IIB increases strength and lifespan in myotubularin (show MTM1 Proteins)-deficient mice.
Akt (show AKT1 Proteins) isoforms are not essential for for the ability of ActRIIB inhibition to regulate muscle size and function .
ActRIIB plays a role in the specification of left-sidedness in developing mice
Activin type IIB(ActRIIB) and its subfamily receptor, Activin type IIA (ActRIIA (show ACVR2A Proteins)), cooperatively mediate the Gdf11 (show GDF11 Proteins) signal in patterning the axial vertebrae
ActRIIB is expressed in the early development of thymocytes.
genetic evidence strongly suggested that ActRIIB and Smad2 (show SMAD2 Proteins) function in the same signaling pathway to regulate axial patterning and pancreas islet formation by means of a threshold mechanism.
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling\; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.
activin A receptor, type IIB
, activin receptor type IIB
, activin receptor type-2B-like
, activin type IIB receptor
, activin receptor type-2B
, testicular activin receptor IIB
, ActRIIB type II activin receptor B
, Activine receptor 2b (transmembrane serine kinase)
, activin receptor IIB