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PCTAIRE1 has a role in regulating p27 (show PAK2 Proteins), c-Myc (show MYC Proteins) levels and tumor growth in cutaneous cutaneous squamous cell carcinoma cells
CDK-16 upregulation in serous EOC cells may represent a negative feedback loop to promote ovarian cell differentiation in malignantly-transformed serous epithelial ovarian cancer cells
GALNT7 (show GALNT7 Proteins) and CDK16 were confirmed to be the direct targets of miR (show MLXIP Proteins)-494. These results suggested that miR (show MLXIP Proteins)-494 play an inhibitory role in the tumorigenesis of NPC (show NPC1 Proteins)
Activation of PCTAIRE-1 is mediated through interaction with the phosphorylated form of cyclin Y (show CCNY Proteins) in complex with 14-3-3 (show YWHAQ Proteins).
PCTK1 in the proliferation and survival of medulloblastoma characterized by cMYC (show MYC Proteins) amplification
PCTK1 regulates spindle orientation through phosphorylation of Ser83 on KAP0, a regulatory subunit of protein kinase A.
An unexpected role for PCTAIRE1 in regulating p27 (show PAK2 Proteins) stability, mitosis, and tumor growth.
Dysfunction of MKL2 and its transcriptional coactivation partner, serum response factor (SRF), was supported by a decrease in gene and protein expression of PCTAIRE1, a downstream target of MKL2:SRF heterodimer transcriptional activation
Pctaire1 exerts promyogenic effects by regulating myoblast migration and process formation during skeletal myogenesis
a novel function of BRSK2 (show BRSK2 Proteins) in the regulation of GSIS in beta-cells via a PCTAIRE1-dependent mechanism and suggest that BRSK2 (show BRSK2 Proteins) is an attractive target for developing novel diabetic drugs.
CCNYL1 regulates spermatogenesis through the interaction and modulation of CDK16.
Mice lacking CDK16 developed normally, but male mice were infertile. Spermatozoa isolated from their epididymis displayed thinning and elongation of the annulus region, adopted a bent shape, and showed impaired motility.
Cdk5 (show CDK5 Proteins)-dependent phosphorylation of Pctaire1 at Ser95 plays an important role in dendrite development
findings demonstrate that Pctaire1 interacts with p35 (show CDK5R1 Proteins), both in vitro and in vivo, and that phosphorylation of Pctaire1 by Cdk5 (show CDK5 Proteins) enhances its kinase activity
The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal transduction cascades in terminally differentiated cells\; in exocytosis\; and in transport of secretory cargo from the endoplasmic reticulum. This gene is thought to escape X inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms.
PCTAIRE protein kinase 3
, PCTAIRE protein kinase 1
, cyclin-dependent kinase 16
, PCTAIRE-motif protein kinase 1
, cell division protein kinase 16
, serine/threonine-protein kinase PCTAIRE-1
, PCTAIRE-1 protein kinase, alternatively spliced