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anti-Human Endothelin 1 Antibodies:
anti-Rat (Rattus) Endothelin 1 Antibodies:
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Dog (Canine) Monoclonal Endothelin 1 Primary Antibody for ICC, FACS - ABIN152685
Talati, West, Blackwell, Loyd, Meyrick: BMPR2 mutation alters the lung macrophage endothelin-1 cascade in a mouse model and patients with heritable pulmonary artery hypertension. in American journal of physiology. Lung cellular and molecular physiology 2010
Show all 2 references for ABIN152685
Human Polyclonal Endothelin 1 Primary Antibody for EIA, IF - ABIN952084
Kaparianos, Argyropoulou, Efremidis, Flordellis, Spiropoulos: Decline in FEV1 related to genetic polymorphisms (+138insA/delA and Lys198Asn) of the endothelin-1 gene in COPD. A pilot study. in European review for medical and pharmacological sciences 2010
Show all 2 references for ABIN952084
Human Polyclonal Endothelin 1 Primary Antibody for EIA, FACS - ABIN952083
Gonsalves, Kalra: Endothelin-1-induced macrophage inflammatory protein-1beta expression in monocytic cells involves hypoxia-inducible factor-1alpha and AP-1 and is negatively regulated by microRNA-195. in Journal of immunology (Baltimore, Md. : 1950) 2010
Show all 2 references for ABIN952083
Cow (Bovine) Polyclonal Endothelin 1 Primary Antibody for IHC, ELISA - ABIN1582247
Hayashi, Hosoe, Takahashi: Placental expression and localization of endothelin-1 system and nitric oxide synthases during bovine pregnancy. in Animal reproduction science 2012
Show all 2 references for ABIN1582247
Human Polyclonal Endothelin 1 Primary Antibody for EIA, IHC (fro) - ABIN191753
Ergün, Harneit, Paust, Mukhopadhyay, Holstein: Endothelin and endothelin receptors A and B in the human testis. in Anatomy and embryology 1999
Mouse (Murine) Polyclonal Endothelin 1 Primary Antibody for IHC, WB - ABIN3021076
Swigris, Brown: The role of endothelin-1 in the pathogenesis of idiopathic pulmonary fibrosis. in BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 2010
Human Monoclonal Endothelin 1 Primary Antibody for IHC (fro), RIA - ABIN110809
Yao, Morioka, Li, Oite: Endothelin is a potent inhibitor of matrix metalloproteinase-2 secretion and activation in rat mesangial cells. in American journal of physiology. Renal physiology 2001
Phylogenetic analysis of conserved grhl (show GHRL Antibodies)-binding sites in gene regulatory regions identified endothelin-1 (edn1) as a putative direct grhl3 (show GRHL3 Antibodies) target gene, and this was confirmed by chromatin precipitation assays in embryos.
EDN1 plays an important role in hepatocellular carcinoma progression by activating the PI3K/AKT pathway and is regulated by miR-1.
Data suggest that edn1/ednraa (show EDNRA Antibodies) (endothelin-1/endothelin-1 receptor type A (show EDNRA Antibodies)) signaling is involved in acid-base regulation and transepithelial proton secretion via vacuolar proton-translocating ATPase (show DNAH8 Antibodies) in zebrafish embryonic skin.
These findings point to complexity of regulation by edn1 and hand2 at the earliest stages of pharyngeal arch development, in which control of growth and morphogenesis can be genetically separated.
Endothelin 1 combines with Bone Morphogenetic Proteins to pattern the dorsal-ventral axis of the craniofacial skeleton.
activation of Endothelin-1 signaling in craniofacial patterning
Edn1 from the pharyngeal ectoderm signals through Ednra (show EDNRA Antibodies) proteins to direct early dorsoventral patterning of the skeletogenic neural crest.
The role of endothelin-1 and light in the regulation of melanopsins and the clock proteins in an embyronic cell line is reported.
This is the first report describing the cDNA encoding preproendothelin-1 in an amphibian species.
A new role for et-1 signaling during early neural crest specification is reported.
Big ET-1 was strongly and independently associated with coronary artery ectasia by multivariate analysis
Leptin (show LEP Antibodies) to insulin (show INS Antibodies) and adiponectin (show ADIPOQ Antibodies) to endothelin ratios are novel derived biomarkers useful for noninvasive diagnostics of initial stages of coronary lesions in patients with coronary artery disease.
The conjunct use of Big-ET-1 and NT-proBNP improves the risk stratification of patients with intermediate to high risk of cardiovascular (CV) disease death and congestive heart failure. Big-ET-1improves risk stratification in patients referred for coronary angiography.
The paternal rs5370 polymorphism decreases the risk for preeclampsia and is not associated with placental expression of the EDN1 gene.
high percentages of HIF-1alpha (show HIF1A Antibodies) (100%), VEGF (show VEGFA Antibodies) (89.5%), iNOS (show NOS2 Antibodies) (78.9%), and ET-1 (84.2%) expressions were observed in congenital heart disease autopsy cases and this was found to be significant.
The level of ET-1 and eNOS (show NOS3 Antibodies) plasma was not significantly different between the CMS (show Cd2ap Antibodies) patients and healthy controls
Coronary occlusion patients in the poor coronary collateral circulation ( CCC ) group had a higher ET1 level than those in the good CCC group (0.59 +/- 0.48 vs. 0.39 +/- 0.32 pmol/L, p < 0.001), and the ET1 values increased with the descent of the Rentrop grades (p for trend < 0.001).
Activin A (show INHBA Antibodies) and preeclamptic serum upregulate ET-1, ICAM-1 (show ICAM1 Antibodies), and VCAM-1 (show VCAM1 Antibodies) in human umbilical vein endothelial cells, consistent with activin A (show INHBA Antibodies) contributing to the pathophysiology of preeclampsia.
ET1 gene and ECE-1 expression levels in human umbilical vein endothelial cells and ET-1 expression levels in the cell culture supernatants increased significantly in some experimental groups compared with those in the control group.
Serum and synovial fluid endothelin-1 concentrations are correlated with the development and progression of knee osteoarthritis.
sub-vasomotor concentration of ET-1 leads to vascular dysfunction by impairing endothelium-dependent NO-mediated dilation via p38 (show MAPK14 Antibodies) kinase-mediated production of superoxide from NADPH oxidase (show NOX1 Antibodies) following ETA receptor activation
ET1 was lowest in kidneys removed from live pigs, greater in kidneys from pigs with brain death, and greatest in kidneys from pigs with cardiac arrest.
ET-1 contributes to formation of oedema during experimental sepsis by a novel mechanism involving increased HBP (show HEBP1 Antibodies) release from neutrophils.
Endothelin-1 expression is upregulated following therapeutic hypothermia after cardiac arrest.
ET-1 produces contraction of the urinary bladder neck muscles via muscular ET(A (show EDNRA Antibodies)) receptors coupled to extracellular Ca(2 (show CA2 Antibodies)+) entry via VOC (L-type) and non-VOC channels.
Endothelin-1 elevation is not only a conserved phenomenon in a pig traumatic brain injury (TBI) model, but it is a likely target for understanding the observed enhanced vascular response to TBI.
interleukin-6 (show IL6 Antibodies), endothelin ET-1, and apoptotic Bak (show BAK1 Antibodies) and Bcl-XL (show BCL2L1 Antibodies) genes have roles in small bowel transplantation, in a swine model of ischemia and reperfusion injury
ET-1 elicits a different pattern of Src (show SRC Antibodies) family kinase (SFK) activation and might trigger a different pattern of SFK activation from that caused by ATP and UTP.
Compared with the untreated group, the levels of serum ET-1 after acute myocardial infarction and reperfusion were significantly decreased in the Xuefu Zhuyu-treated group.
study suggests a possible role for endothelin-1(resulting from the actions of endothelin-converting enzyme-1 (show ECE1 Antibodies)) acting via endothelin receptor A (show EDNRA Antibodies) in the control of luteolytic sensitivity in the pig
Data suggest that, in Fallopian tubes, endothelins (EDN1, EDN2 (show EDN2 Antibodies), EDN3 (show EDN3 Antibodies)) and EDN (show RNASE2 Antibodies)-converting enzymes (ECE1 (show ECE1 Antibodies), ECE2 (show ECE2 Antibodies)) are expressed in epithelial cells; EDN (show RNASE2 Antibodies) receptors (EDNRA (show EDNRA Antibodies), EDNRB (show EDNRB Antibodies)) are present in smooth-muscle. Expression of EDN1, EDN2 (show EDN2 Antibodies), and ECE2 (show ECE2 Antibodies) is highest on day of ovulation. EDN (show RNASE2 Antibodies)/ENDR signaling appears to participate Fallopian tube function. These studies were conducted in Holstein cows.
results suggest that ET-1-induced activation of proMMP-2 is mediated via cross-talk between NADPH oxidase (show NOX1 Antibodies)-PKCalpha (show PKCa Antibodies)-p(38)MAPK (show MAPK1 Antibodies) and NFkappaB-MT1MMP (show MMP14 Antibodies) signaling pathways along with a marked decrease in TIMP-2 (show TIMP2 Antibodies) expression in the cells
We demonstrated that (i) treatment of bovine pulmonary artery smooth muscle cells with ET-1 stimulates cPLA2 (show PLA2G4A Antibodies) activity in the cell membrane.
Differential cell-specific and spatiotemporal expression of the EDN1 system and NOS (show NOS Antibodies) in the bovine utero-placental unit may be associated with regulation of vascular and cellular functions during pregnancy.
Oxidized LDL is a stimulus of ET-1 production in cultured vascular endothelial cells.
Endothelin-1 decreases ethanolamine plasmalogen levels and evokes platelet-activating factor production in brain microvessels
prostaglandin F2alpha, endothelin-1, and angiotensin II may interact with each other in a local positive feedback manner to activate their secretion in the regressing corpus luteum, thus accelerating and completing luteolysis
LOX-1 (show OLR1 Antibodies) and CD40 (show CD40 Antibodies) synergistically, but through a distinct pathway, work to induce endothelin-1 expression in endothelial cells.
Elevated local expression of ET-1 and Ednra/Ednrb (show EDNRB Antibodies) during the peri (show PLIN1 Antibodies)-ovulatory period induces the high contractile activity of the oviduct to optimize gamete transport.
Suggest that the activation of a local positive feedback mechanism in the corpus luteum among ET-1, Ang II (show AGT Antibodies) and PGF2alpha might play a functional role in the paracrine modulation of luteolytic cascade.
Review and Meta-Analysis of ET-1 Transgenic Mice provides robust evidence that global ET-1 overexpression in mice lowers blood pressure in an age-dependent manner. Older ET-1+/+ mice have a somewhat more pronounced reduction of blood pressure.
evidence supports a model in which aldosterone activation of the mineralocorticoid receptor (show NR3C2 Antibodies) (MR) results in the MR-hormone complex binding at HRE at -671bp to open chromatin structure around other regulatory elements in the Edn1 gene
Decreased ET-1 levels were associated with greater activation of NLRP3 (show NLRP3 Antibodies) and IL-1beta (show IL1B Antibodies) in normal glucose. High glucose increased NLRP3 (show NLRP3 Antibodies) markers and activation compared to normal and low glucose
AMPAR-mediated glutamatergic neurotransmission may underlie the mechanism of ET1-ET(A (show EDNRA Antibodies))R signaling pathway in the regulation of anxiety.
indicate that endothelin-1 is critical in the development of cerebrovascular and cognitive impairments with experimental cerebral malaria
increased extrarenal vascular ET-1 production in response to HS intake is mediated by increased extracellular osmolarity and plays a critical role in regulating skin storage of Na(+)
PPARgamma (show PPARG Antibodies) regulates miR (show MLXIP Antibodies)-98 to modulate ET-1 expression and pulmonary endothelial cell proliferation in pulmonary hypertension.
these results indicated that I/R induced upregulation of ET1 and ETA in the kidneys, which was, at least in part, dependent on the production of inflammatory cytokines.
we have demonstrated that the expression of ET-1 and IL-25 (show IL25 Antibodies) was coordinately upregulated in the lesional keratinocytes of patients with AD and a murine AD model.
Short-term hyperinsulinaemia leads to increased vascular resistance in the equine digit and increased expression of ET-1 in the laminar tissue.
Plasma ET-1 levels of rabbits increased significantly in fluorinated groups compared with those in the control group.
Dynamic monitoring and comparison of plasma levels of ET, CGRP, NO, and MDA as well as SOD activity revealed that appropriate intervention of these factors may reduce reperfusion injury
In a saline lavage-induced lung injury model, both circulatory and pulmonary ET-1 levels increased.
Data suggest elevated levels of endothelin-1, as exhibited in cardiovascular diseases, facilitate development of ventricular arrhythmia by steepening action potential duration restitution and by increasing beat-to-beat variability of repolarization.
High levels of ET-1 are closely associated with BBB (show ALMS1 Antibodies) disruption. ET-1 may play an important role in the pathogenesis of secondary brain injury after ICH (show ACE Antibodies).
After subarachnoid hemorrhage, the contractile response to ET-1 was enhanced, and the ET(A (show EDNRA Antibodies)) receptor expression was upregulated in the basilar artery.
After acute pulmonary thromboembolism, thrombolytic and anti-inflammatory treatment could decrease acute lung injury induced by ET-1 and NF-kappaB (show NFKB1 Antibodies) activation. [endothelin-1; NFKB]
The increase in myocardial distensibility induced by endothelin-1 is absent in heart failure and is dependent on nitric oxide and prostaglandin release.
Endothelin-1 enhances nuclear Ca2 (show CA2 Antibodies)+ transients in atrial myocytes through Ins (show INS Antibodies)(1,4,5)P3-dependent Ca2 (show CA2 Antibodies)+ release from perinuclear Ca2 (show CA2 Antibodies)+ stores
The enhancement of gap junction intercellular communication is activated by endothelin-1 via modulating the expression of connexin43 (show GJA1 Antibodies), and plays an important role in the pathogenesis of cerebral vasospasm
The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. This peptide is a potent vasoconstrictor and is produced by vascular endothelial cells. Endothelin 1 also can affect the central nervous system. Two transcript variants encoding different isoforms have been found for this gene.
, endothelin 1
, gene for endothelin
, preproendothelin 1