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Browse our FKBP1B Proteins (FKBP1B)

Full name:
FK506 Binding Protein 1B, 12.6 KDa Proteins (FKBP1B)
On www.antibodies-online.com are 14 FK506 Binding Protein 1B, 12.6 KDa (FKBP1B) Proteins from 8 different suppliers available. Additionally we are shipping FKBP1B Antibodies (29) and FKBP1B Kits (5) and many more products for this protein. A total of 51 FKBP1B products are currently listed.
Synonyms:
12.6kDa, AW494148, calstabin2, DKFZp459K1429, FKBP1B, FKBP1L, FKBP12.6, MGC68829, OTK4, PKBP1L, PPIase
list all proteins Gene Name GeneID UniProt
FKBP1B 14226 Q9Z2I2
FKBP1B 58950 P97534
FKBP1B 2281 P68106

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FKBP1B Proteins (FKBP1B) by Origin

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Top referenced FKBP1B Proteins

  1. Human FKBP1B Protein expressed in Escherichia coli (E. coli) - ABIN667593 : Deivanayagam, Carson, Thotakura, Narayana, Chodavarapu: Structure of FKBP12.6 in complex with rapamycin. in Acta crystallographica. Section D, Biological crystallography 2000 (PubMed)
    Show all 2 references for ABIN667593

  2. Human FKBP1B Protein expressed in Wheat germ - ABIN1354118 : Åström-Olsson, Li, Olofsson, Borén, Öhlin, Grip: Impact of hypoxia, simulated ischemia and reperfusion in HL-1 cells on the expression of FKBP12/FKBP12.6 and intracellular calcium dynamics. in Biochemical and biophysical research communications 2012 (PubMed)

More Proteins for FKBP1B Interaction Partners

Mouse (Murine) FK506 Binding Protein 1B, 12.6 KDa (FKBP1B) interaction partners

  1. Calstabin2 as a key modulator of cardiac aging.

  2. Sirolimus-FKBP12.6 impairs endothelial barrier function by activation of protein kinase C-alpha (show PKCa Proteins) and downstream disruption of the p120 (show CTNND1 Proteins)-VE cadherin (show CDH5 Proteins) interaction in vascular endothelium.

  3. genetic approaches confirm the role of FKBP12.6 in regulating cardiac ryanodine receptors

  4. the impact of simulated ischemia and reperfusion on expression of the calcium handling proteins FKBP12 (show FKBP1A Proteins) and FKBP12.6, and intracellular calcium dynamics was investigated.

  5. Transcription factor CHF1/Hey2 (show HEY2 Proteins) regulates EC coupling and heart failure in mice through regulation of FKBP12.6.

  6. Cardiac FKBP12.6 overexpression in the mouse blunts pressure overload-induced maladaptive left ventricular remodelling.

  7. FKBP12.6 removal enhanced, whereas RyR2 gene deletion blocked the hypoxic increase in Ca(2 (show CA2 Proteins)+)(i) in pulmonary artery smooth muscle cells.

  8. Characterize the kinetics of FKBP12/12.6 binding to RyR2 in ventricular myocytes and effects on calcium signaling.

  9. FKBP12.6(-/-) mice displayed hyperinsulinemia, & resistance to high fat diet-induced hyperglycemia, suggesting that FKBP12.6 plays an important role in insulin (show INS Proteins) secretion & blood glucose control.

  10. During exercise, RyR2 phosphorylation by protein kinase A dissociates FKBP12.6 from the channel, increasing Ca(2 (show CA2 Proteins)+) release and cardiac contractility. FKBP12.6(-/-) mice showed exercise-induced arrhythmias.

Human FK506 Binding Protein 1B, 12.6 KDa (FKBP1B) interaction partners

  1. results suggest that both FKBP12.6 and FKBP12 play critical roles in regulating RyR2 function by facilitating the termination of SOICR.

  2. RyRs have been identified as important targets of FKBP12 (show FKBP1A Proteins) and FKBP12.6, members of the immunophilin (show FKBP1A Proteins) family

  3. How phosphorylation of RyR (show RYR1 Proteins) affects channel activity and whether proteins such as the FK-506 binding proteins (FKBP12 (show FKBP1A Proteins) and FKBP12.6) are involved in heart failure

  4. Sirolimus-FKBP12.6 impairs endothelial barrier function by activation of protein kinase C-alpha (show PKCa Proteins) and downstream disruption of the p120 (show HNRNPU Proteins)-VE cadherin (show CDH5 Proteins) interaction in vascular endothelium.

  5. These data corroborate other studies suggesting that mutations in FKBP12 (show FKBP1A Proteins) and FKBP12.6 genes are not commonly related to cardiac diseases.

  6. FKBP12.6-deficient mice with cardiac hypertrophy do not display exercise-induced arrhythmia and/or sudden cardiac death.

  7. analysis of the ryanodine receptor (show RYR3 Proteins) FK506-binding protein (show FKBPL Proteins) subunit

  8. Characterize the kinetics of FKBP12/12.6 binding to RyR2 in ventricular myocytes and effects on calcium signaling.

  9. localization of binding site to the NH2-terminal domain of the cardiac Ca2+ release channel

  10. Data show that VTSIP- and ARVD2-associated point mutations influence positively and negatively, respectively, the binding of RyR2 to its gating protein FKBP12.6.

Rabbit FK506 Binding Protein 1B, 12.6 KDa (FKBP1B) interaction partners

  1. phosphorylation and K201 acted similarly to change the conformation of RyR1 (show RYR1 Proteins)/2 and regulate FKBP12 (show FKBP1A Proteins)/12.6 binding.

  2. Stoichiometry of binding sites and FKBP (show FKBP7 Proteins) exchange binding.

FKBP1B Protein Profile

Protein Summary

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms.

Alternative names and synonyms associated with FKBP1B

  • FK506 binding protein 1B, 12.6 kDa (FKBP1B)
  • FK506 binding protein 1B, 12.6 kDa (fkbp1b)
  • FK506 binding protein 1B, 12.6 kDa (LOC100230320)
  • FK506 binding protein 1b (Fkbp1b)
  • FK506 binding protein 1B (Fkbp1b)
  • 12.6kDa protein
  • AW494148 protein
  • calstabin2 protein
  • DKFZp459K1429 protein
  • FKBP1B protein
  • FKBP1L protein
  • FKBP12.6 protein
  • MGC68829 protein
  • OTK4 protein
  • PKBP1L protein
  • PPIase protein

Protein level used designations for FKBP1B

FK506 binding protein 12.6 , peptidyl-prolyl cis-trans isomerase FKBP1B , FK506 binding protein 1B, 12.6 kDa , calstabin2 , 12.6 kDa FK506-binding protein , 12.6 kDa FKBP , FK506-binding protein 12.6 , FK506-binding protein 1B , FKBP-12.6 , FKBP-1B , PPIase FKBP1B , immunophilin FKBP12.6 , rotamase , calstabin-2 , calstabin 2 , h-FKBP-12 , Immunophilin FKBP12.6 , PPIase 1B , Rotamase 1B , peptidyl-prolyl cis-trans isomerase 1B , peptidyl-prolyl cis-trans isomerase; PPIase

GENE ID SPECIES
395254 Gallus gallus
399004 Xenopus laevis
612965 Canis lupus familiaris
741549 Pan troglodytes
100125114 Xenopus (Silurana) tropicalis
100173212 Pongo abelii
100230320 Taeniopygia guttata
14226 Mus musculus
58950 Rattus norvegicus
2281 Homo sapiens
785179 Bos taurus
100008888 Oryctolagus cuniculus
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