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anti-Human G Protein-Coupled Receptor 119 Antibodies:
anti-Rat (Rattus) G Protein-Coupled Receptor 119 Antibodies:
anti-Mouse (Murine) G Protein-Coupled Receptor 119 Antibodies:
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Human Polyclonal G Protein-Coupled Receptor 119 Primary Antibody for ELISA, WB - ABIN409074
Overton, Fyfe, Reynet: GPR119, a novel G protein-coupled receptor target for the treatment of type 2 diabetes and obesity. in British journal of pharmacology 2008
Angelica dahurica extract-treated cells showed significant increases in GPR119 activation, intracellular cAMP levels, GLP-1 (show GCG Antibodies) levels and glucose-stimulated insulin (show INS Antibodies) secretion as compared with controls
Describe novel small-molecule GPR119 agonists with high receptor selectivity and capacity to induce glucose-stimulated insulin (show INS Antibodies) secretion.
The GPR119 agonist, HD0471042 increased intracellular cAMP levels in stably human GPR119 expressing CHO cells.
Oxidized-LDL significantly induces lincRNA-DYNLRB2 (show DYNLRB2 Antibodies)-2 expression, which promotes ABCA1 (show ABCA1 Antibodies)-mediated cholesterol efflux and inhibits inflammation through GPR119 in THP-1 (show GLI2 Antibodies) cells.
Replacement of the three methyl groups in 1 with metabolically stable moieties led to the identification of compound 34, a potent and efficacious GPR119 agonist with improved pharmacokinetic (PK) properties.
transfection of GLUTag cells with recombinant human GPR119 results in a constitutive and apparently ligand-independent increase of proglucagon (show GCG Antibodies) gene promoter activity and proglucagon (show GCG Antibodies) mRNA content.
Results provide evidence of an islet-gastrointestinal distribution of GPR119, its expression in pancreatic beta and alpha cells, and its possible involvement in islet function.
Data suggest that GPR119 activation/up-regulation in skeletal muscle impairs fatty acid and glucose oxidation; diet-induced obesity appears to up-regulate skeletal muscle GPR119.
Data show that Phe-V:13 can serve as an aromatic lock for the proposed active conformation of the Trp (show TBPL1 Antibodies)-VI:13 rotameric switch, being involved in the global movement of TM-V and TM-VI in 7TM receptor (show CHRM2 Antibodies) activation.
findings show that N-oleoyldopamine (OLDA)& structurally related hydroxybenzyl amides are robust activators of GPR119; studies indicate that multiple, distinct classes of lipid amides, acting via GPR119, may be important modulators of glucose homeostasis
beta-cell GPR119 expression is dispensable for the physiological control of insulin (show INS Antibodies) secretion.
we offer evidence for a GPR119-based signaling system in the mammalian eye, with receptors, ligands, and function in the form of a reduction in IOP. Notably this reduction in pressure is restricted to female mice
fat-derived monoacylglycerols are potent candidates for mediating fat-induced GLP-1 (show GCG Antibodies) release through GPR119 in vivo.
GPR119 in L-cells plays a key role in oral lipid-triggered GLP-1 (show GCG Antibodies) secretion.
Data indicate that G-protein coupled receptor 119 (GPR119) knockout prevents the therapeutic effects of Gordonoside F.
Novel GPR119 agonist, HD0471042, effectively controlled glucose levels and prevented weight gain in type 2 diabetic mice.
AR231453, a GPR119 agonist, can stimulate beta-cell replication and improve islet graft function
Our results demonstrate that combining a GPR119 agonist with a DPP-IV (show DPP4 Antibodies) inhibitor may offer a novel therapeutic strategy for stimulating beta-cell regeneration and reversing diabetes.
This gene encodes a member of the rhodopsin subfamily of G-protein-coupled receptors that is expressed in the pancreas and gastrointestinal tract. The encoded protein is activated by lipid amides including lysophosphatidylcholine and oleoylethanolamide and may be involved in glucose homeostasis. This protein is a potential drug target in the treatment of type 2 diabetes.
G protein-coupled receptor 119
, G-protein coupled receptor 2
, glucose-dependent insulinotropic receptor
, G-protein coupled receptor 119