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GHRH and GHRH-R (show GHRHR Proteins) loops are involved in placental choriocarcinoma cell line viability and apoptosis through Akt (show AKT1 Proteins) and eIF2a (show EIF2S1 Proteins) pathways.
GHRH excess and blockade in X-LAG (show STMN1 Proteins) syndrome
case Report: multiple endocrine neoplasia type 1 family characterized by primary hyperparathyroidism, in association with acromegaly because of ectopic GHRH secretion by a pancreatic neuroendocrine tumor in a young man.
After 20 weeks of GHRH administration, gamma-aminobutyric acid levels are increased in all brain regions, N-acetylaspartylglutamate levels are increased in the dorsolateral frontal cortex, and myoinositol levels are decreased in the posterior cingulate.
The pathomechanisms involved in the genetic defects at both ends of the GHRH-IGF-1 (show IGF1 Proteins) axis.
Pretreatment with GHRH for 12 days could restore pituitary responsiveness to GHRH either in healthy aged men and growth hormone (show GH1 Proteins)-deficient adult patients.
Studies indicate that appropriate consideration should be given to genetic defects in GH-1 (show GH1 Proteins), IGF-I (show IGF1 Proteins) and GHRH causing growth hormone (GH (show GH1 Proteins)) deficiency.
GHRH stimulated the NF-kappa b (show NFKB1 Proteins) transcription factor, which is not only known to activate angiogenic factors but also the expression of genes involved in encoding enzymes in the prostaglandin-synthesis pathway such as COX-2 and the iNOS (show NOS2 Proteins)
GHRH mutations were not identified in a selected cohort of patients with isolated GH deficiency, suggesting that, if they exist, they may be an extremely rare cause of isolated GH deficiency.
The common regenerative and neuroprotective effects of epidermal growth factor (EGF (show EGF Proteins)) and growth hormone releasing hormone peptide(GHRP (show GHSR Proteins))-6 are associated with their versatile pro-survival and pro-regenerative mechanisms.
Concentrations of GHRH in CSF (show CSF2 Proteins) were weakly correlated with serum concentrations of growth hormone (GH (show GH1 Proteins)); 58% of the GH pulses were preceded by a pulse of GHRH and 90% of the GHRH pulses occurred within 20 min preceding a pulse of GH.
polymorphisms in GHRH might be one of the important genetic factors that influence carcass yield in beef cattle
Growth hormone-releasing hormone agonist markedly improve therapeutic angiogenesis in hindlimb ischemia by increasing the viability and mobility of mesenchymal stem cells.
The increased food intake observed in GHRH ablated animals is associated with increased locomotor and thermogenic activity.
In male mice GHRH deficiency brings about an increased physical activity and decreased anxiety- and depression-related behaviour, possibly related to increased TRH (show TRH Proteins) and decreased NE levels in the brain.
These data suggest that ghrelin (show GHRL Proteins) increases GHRH neuron excitability by increasing action potential firing rates and decreasing the strength of GABA inputs, leading to enhanced GHRH release; and that obestatin counteracts ghrelin (show GHRL Proteins) actions.
Findings establish a novel ontogenetic profile for GHRH neurons and suggest previously undiscovered roles for peripubertal gonadal factors in establishing population size in both sexes.
treatment with a GHRH antagonist has positive effects on some aspects of aging, including an increase in telomerase activity.
Review. Growth hormone-releasing hormone (GHRH) is a hypothalamic hormone that is essential for normal expansion of the somatotrope lineage during pituitary development.
GHRH plays a crucial role in the development of experimental autoimmune encephalomyelitis.
Efficient production of mature GHRH from pro-GHRH is a stepwise process mediated predominantly by furin (show FURIN Proteins) at the N-terminal cleavage site followed by PC1/3 (show PCSK1 Proteins) at the C terminus
The protein encoded by this gene belongs to the glucagon family and is a preproprotein that is produced in the hypothalamus. The preproprotein is cleaved to form a 44 aa factor, also called somatocrinin, that acts to stimulate growth hormone release from the pituitary. Variant receptors for somatocrinin have been found in several types of tumors, and antagonists of these receptors can inhibit the growth of the tumors. Defects in this gene are a cause of dwarfism, while hypersecretion of the encoded protein is a cause of gigantism.
growth hormone-releasing hormone
, growth hormone-releasing factor