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Findings indicate that PERK kinase-activating transcription factor 4 (ATF4 (show ATF4 ELISA Kits)) pathway affected the efficiency of X-box binding protein 1 (XBP1 (show XBP1 ELISA Kits)) mRNA splicing by regulating inositol-requiring enzyme 1alpha (IRE1alpha (show ERN1 ELISA Kits)) expression.
This study demonstrated that Perk Ablation Ameliorates Myelination in S63del-Charcot-Marie-Tooth 1B Neuropathy.
Data show that EIF2AK3/PERK-mediated downregulation of miR (show MLXIP ELISA Kits)-424(322)-503 cluster regulates optimal activation of IRE1 (show ERN1 ELISA Kits) protein and activating transcription factor 6 (ATF6 (show ATF6 ELISA Kits)) during conditions of endoplasmic reticulum stress.
Inhibition of eIF2alpha phosphorylation via PERK suppression and reversal of de novo protein synthesis deficits can mitigate cognitive deficits in neurodegenerative diseases.
PlGF (show PGF ELISA Kits) inhibition attenuates PERK activation, likely by tempering hypoxia in HCC (show FAM126A ELISA Kits) via vessel normalisation. The UPR is able to regulate PlGF (show PGF ELISA Kits) expression, suggesting the existence of a feedback mechanism for hypoxia-mediated UPR
this study demonstrates novel roles for the endoplasmic reticulum stress-response transducer PERK and a downstream effector of its activation, CHOP (show DDIT3 ELISA Kits), in tubule cell production of fibronectin (show FN1 ELISA Kits)
Nck1 silencing in pancreatic beta cells promotes PERK activation and signaling to protect beta cells against pathological stresses.
Nitric oxide can S-nitrosylate the endoplasmic reticulum stress sensors IRE1alapha and PERK.
Results show that PERK-eIF2alpha (show EIF2A ELISA Kits)-mediated translational failure is a key process leading to neuronal loss in a mouse model of frontotemporal dementia, where the misfolded protein is a form of mutant tau
whole-body or pancreas-specific Perk ablation in mice leads to an increase in IFNAR1 (show IFNAR1 ELISA Kits) protein levels and signaling in pancreatic tissues.
BiP/GRP78 (show HSPA5 ELISA Kits) and PERK were highly expressed.
plasma exposure resulted in expression of unfolded protein response (UPR) proteins such as glucoserelated protein 78 (GRP78 (show HSPA5 ELISA Kits)), protein kinase (show CDK7 ELISA Kits) R (PKR (show PKLR ELISA Kits))like ER kinase (PERK), and inositolrequiring enzyme 1 (IRE1 (show ERN1 ELISA Kits)). Elevated expression of spliced Xbox binding protein 1 (XBP1 (show XBP1 ELISA Kits)) and CCAAT/enhancerbinding protein homologous protein (CHOP (show DDIT3 ELISA Kits)) further confirmed that ROS (show ROS1 ELISA Kits) generatedby NTGP induces apoptosis through the ER stress
PERK-eIF2alpha (show EIF2A ELISA Kits)-ATF4 (show ATF4 ELISA Kits) signaling pathway mediated by endoplasmic reticulum stress involved in osteoblast differentiation of periodontal ligament cells under cyclic mechanical force.
EnR (show LARGE ELISA Kits) stress assessed by expression of PERK and p-eIF2alpha (show EIF2A ELISA Kits) was significantly associated with tumor infiltrating lymphocytes in HER2 (show ERBB2 ELISA Kits)-positive breast cancer.
Influenza A virus downregulates the host unfolded protein response mediated by the PERK protein.
Using drugs that specifically inhibit or activate the PERK or IRE1alpha sensors, we demonstrate that signalling through the PERK axis activates this expression, through a transcriptional mechanism
Data show CGK733 induced microtubule associated protein LC3B (show MAP1LC3B ELISA Kits) formation upstream of AMP-activated protein kinase (show PRKAA2 ELISA Kits) and protein kinase (show CDK7 ELISA Kits) RNA-like endoplasmic reticulum kinase/CCAAT-enhancer-binding protein homologous protein (show DDIT3 ELISA Kits) pathways and p21 Cip1 (show CDKN1A ELISA Kits) expression.
Data from 2 consanguineous families suggest EIF2AK3 mutations (c.1337_1338insT/p.K346*; c.3009C>T/p.R903*) account for Wolcott-Rallison syndrome; ultrastructural features of autopsy materials suggest endoplasmic reticulum dysfunction. [CASE STUDIES]
CGK733-induced intracellular calcium sequestration in pancreatic tumor cells is correlated with the PERK/CHOP (show DDIT3 ELISA Kits) signaling pathway and may also be involved in the dysregulations of calcium-binding proteins.
The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.
eukaryotic translation initiation factor 2-alpha kinase 3
, eukaryotic translation initiation factor 2-alpha kinase 3-like
, PRKR-like endoplasmic reticulum kinase
, pancreatic eIF2-alpha kinase
, eukaryotic translation initiation factor 2 alpha kinase 3
, pancreatic EIF2-alpha kinase