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Our data suggested a potential role of Rab11-FIP2 in tumor progression and provided novel insights into the mechanism of how Rab11-FIP2 positively regulated cell migration and invasion in CRC (show CALR Proteins) cells.
our findings reveal a novel mechanism underlying the role of Rab11-FIP2 in gastric cancer dissemination
Rab11-FIP2 binding to MYO5B is essential for vesicular trafficking in Hela and MDCK cells.
The recruitment of FIP2 is specific since other members of the Rab11-Family of Interacting Proteins do not associate with the chlamydial inclusions.
Rab11A (show RAB11A Proteins)/myosin Vb/Rab11-FIP2 complex frames two late recycling steps of langerin (show CD207 Proteins) from the ERC (show ERC1 Proteins) to the plasma membrane
Rab11-FIP2 functions downstream of Rab11 in endosomal trafficking.
Rab11-FIP2 regulates trafficking at multiple points within the apical recycling system of polarized cells
the FIP2 (show OPTN Proteins) C2 mutant caused a failure at the final budding step in the RSV virus life cycle
Phosphorylation of Rab11-FIP2 on serine 227 by MARK2 (show MARK2 Proteins) regulates an alternative pathway modulating the establishment of epithelial polarity
Data demonstrate that AMPH leads to an increase of NET in endosomes of single boutons and varicosities in a Rab11-dependent manner.
Rab11-FIP2 has a role in the coupling of receptor-mediated endocytosis to the subsequent sorting of receptor-containing vesicles in endosomes [RAB11-FIP2]
A Rab11 effector protein acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Binds preferentially to phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA). Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity.
RAB11 family interacting protein 2
, rab11-family interacting protein 2
, RAB11-FIP2 long isoform
, rab11 family-interacting protein 2
, Rab11-family interacting protein 2