Browse our RAPGEF4 Proteins (RAPGEF4)

On www.antibodies-online.com are 6 Rap Guanine Nucleotide Exchange Factor (GEF) 4 (RAPGEF4) Proteins from 4 different suppliers available. Additionally we are shipping RAPGEF4 Antibodies (41) and RAPGEF4 Kits (1) and many more products for this protein. A total of 54 RAPGEF4 products are currently listed.
Synonyms:
1300003D15Rik, 5730402K07Rik, 6330581N18Rik, CAMP-GEFII, CAMPS, Cgef2, Epac-2, EPAC 2, Epac2, mKIAA4040, Nbla00496, RAPGEF4
list all proteins Gene Name GeneID UniProt
RAPGEF4 11069 Q8WZA2
RAPGEF4 56508 Q9EQZ6
RAPGEF4 252857  

RAPGEF4 Proteins (RAPGEF4) by Origin

More Proteins for RAPGEF4 Interaction Partners

Human Rap Guanine Nucleotide Exchange Factor (GEF) 4 (RAPGEF4) interaction partners

  1. This review focus is on the function of Epac (show RAPGEF3 Proteins) in the heart. Accumulating evidence has revealed that both Epac1 (show RAPGEF3 Proteins) and Epac2 play important roles in the structure and function of the heart under physiological and pathological conditions. [review]

  2. Data show that Epac2 is activated by cAMP and changes its structure. It is involved in cAMP-mediated signal transduction through activation of the Ras-like small GTPase (show RAP2B Proteins) and is expressed mainly in brain, neuroendocrine and endocrine tissues. [review]

  3. Identified a conserved nuclear pore localisation signal (NPLS; amino acids 764-838 of EPAC1 (show RAPGEF3 Proteins)) in the catalytic domains of the cAMP-sensors, EPAC1 (show RAPGEF3 Proteins) and EPAC2A. EPAC1 (show RAPGEF3 Proteins) and EPAC2, display distinct subcellular distributions.

  4. CALR (show CALR Proteins) regulated by EPAC2 in endometrial glandular epithelial cells is critical for the expression of LIF (show LIF Proteins) and PTGS2 (show PTGS2 Proteins)-mediated production of PGE2 through cAMP signaling.

  5. Follow-up replication analyses in up to an additional 21,345 participants identified three new fasting plasma glucose loci reaching genome-wide significance in or near PDK1 (show PDK1 Proteins)-RAPGEF4, KANK1, and IGF1R (show IGF1R Proteins).

  6. EPAC1 and EPAC2 are critical signaling intermediates in osteoclast differentiation that permit RANKL-stimulated NFkB nuclear translocation and actin rearrangements

  7. data show the expression of E (show RAPGEF3 Proteins)PAC is blunted in HPRT-deficient neuron-like cell lines (show HPRT1 Proteins)and fibroblast cells from Lesch-Nyhan syndrome (LNS) (show RAPGEF3 Proteins)patie (show RABGEF1 Proteins)nts; propose that the alterations in (show HPRT1 Proteins)EPAC/RAP1 signaling and cell migration in HPRT deficiency are crucial for neuro-developmental events that may contribute to neurological dysfunctions in LNS

  8. EPAC2-mediated CRT (show SLC6A8 Proteins) expression is essential for the functional and morphological differentiation of endometrial stromal cells into decidual cells

  9. Cigarette smoke extract decreased Epac1 (show RAPGEF3 Proteins) expression, but did not affect Epac2 and PKA expression.

  10. Mechanism of intracellular cAMP sensor Epac2 activation: cAMP-induced conformational changes identified by amide hydrogen/deuterium exchange mass spectrometry

Mouse (Murine) Rap Guanine Nucleotide Exchange Factor (GEF) 4 (RAPGEF4) interaction partners

  1. PACAP (show ADCYAP1 Proteins) could trigger astrocytic differentiation of neural stem cells via Epac2 activation.

  2. Epac2, but not Epac1 (show RAPGEF3 Proteins) has a role in decreasing severity of ischemic retinopathy after retinal ischemia/reperfusion injury

  3. cAMP-GEF (show ARHGEF2 Proteins) II plays a key role in hippocampal functions including behavioral flexibility.

  4. data suggest that cAMP elevation uses an Epac2-dependent pathway to promote transmitter release, and that Epac2 is required to maintain the readily releasable pool at Mossy Fiber synapses in the hippocampus.

  5. Epac1 (show RAPGEF3 Proteins) primarily is capable of inhibiting remodeling processes, whereas Epac2 primarily increases inflammatory processes in vivo

  6. EPAC1 and EPAC2 are critical signaling intermediates in osteoclast differentiation that permit RANKL-stimulated NFkB nuclear translocation and actin rearrangements

  7. data show the expression EPAC (show RAPGEF3 Proteins) is altered in the cortex, striatum and midbrain of HPRT (show HPRT1 Proteins) knockout mouse; propose that the alterations in EPAC (show RAPGEF3 Proteins)/RAP1 (show TERF2IP Proteins) signaling and cell migration in HPRT (show HPRT1 Proteins) deficiency are crucial for neuro-developmental events that may contribute to neurological dysfunctions in Lesch-Nyhan syndrome

  8. DNA methylation (show HELLS Proteins) of alternative promoters directs tissue specific expression of Epac2 isoforms.

  9. Epac2 localization is dynamically controlled by cAMP as well as by Ca(2+)-mediated activation of Ras.

  10. EPAC2A is required for potentiating the early dynamic increase in islet calcium levels after glucose stimulation, which is reflected in potentiated first-phase insulin (show INS Proteins) secretion.

RAPGEF4 Protein Profile

Protein Summary

Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA- independent exocytosis through interaction with RIMS2 (By similarity).

Alternative names and synonyms associated with RAPGEF4

  • Rap guanine nucleotide exchange factor (GEF) 4 (RAPGEF4)
  • Rap guanine nucleotide exchange factor (GEF) 4 (LOC100348394)
  • rap guanine nucleotide exchange factor 4 (PTRG_05798)
  • Rap guanine nucleotide exchange factor (GEF) 4 (Rapgef4)
  • 1300003D15Rik protein
  • 5730402K07Rik protein
  • 6330581N18Rik protein
  • CAMP-GEFII protein
  • CAMPS protein
  • Cgef2 protein
  • Epac-2 protein
  • EPAC 2 protein
  • Epac2 protein
  • mKIAA4040 protein
  • Nbla00496 protein
  • RAPGEF4 protein

Protein level used designations for RAPGEF4

Rap guanine nucleotide exchange factor (GEF) 4 , rap guanine nucleotide exchange factor 4 , rap guanine nucleotide exchange factor 4-like , EPAC 2 , RAP guanine-nucleotide-exchange factor (GEF) 4 , cAMP-regulated guanine nucleotide exchange factor II , exchange factor directly activated by cAMP 2 , exchange protein directly activated by cAMP 2 , putative protein product of Nbla00496 , cAMP-GEFII , cAMP-dependent Rap1 guanine-nucleotide exchange factor , cAMP-regulated guanine nucleotide exchange factor IIB , epac 2

GENE ID SPECIES
459744 Pan troglodytes
429022 Gallus gallus
488402 Canis lupus familiaris
537312 Bos taurus
579050 Strongylocentrotus purpuratus
698148 Macaca mulatta
100025283 Monodelphis domestica
100064121 Equus caballus
100084234 Ornithorhynchus anatinus
100174040 Pongo abelii
100348394 Oryctolagus cuniculus
100401754 Callithrix jacchus
100480097 Ailuropoda melanoleuca
100551109 Meleagris gallopavo
100602878 Nomascus leucogenys
6344052 Pyrenophora tritici-repentis Pt-1C-BFP
11069 Homo sapiens
56508 Mus musculus
252857 Rattus norvegicus
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