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Browse our SMPD3 Proteins (SMPD3)

Full name:
Sphingomyelin Phosphodiesterase 3 Proteins (SMPD3)
On www.antibodies-online.com are 8 Sphingomyelin Phosphodiesterase 3 (SMPD3) Proteins from 4 different suppliers available. Additionally we are shipping SMPD3 Antibodies (51) and SMPD3 Kits (1) and many more products for this protein. A total of 66 SMPD3 products are currently listed.
Synonyms:
4631433G07Rik, AI427456, AW537966, cca1, fro, NSMASE2
list all proteins Gene Name GeneID UniProt
SMPD3 58994 Q9JJY3
SMPD3 94338 O35049
SMPD3 55512 Q9NY59

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SMPD3 Proteins (SMPD3) by Origin

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Mouse (Murine) Sphingomyelin Phosphodiesterase 3 (SMPD3) interaction partners

  1. Study provides evidence that Smpd3 expression in both chondrocytes and osteoblasts is required for normal endochondral bone development.

  2. these results highlight the role of nSMase2 in apoptosis evoked by nutrient starvation that could contribute to the delayed apoptosis of hypertrophic chondrocytes in the growth plate, and emphasize the antiapoptotic properties of HAS2 (show HAS2 Proteins)

  3. nSMase2 activation is required for the development of infection-induced diaphragm calpain activation and muscle weakness.

  4. These results suggest that OTC (show OTC Proteins) is a potent stimulant of nSMase-2 expression and that there may be unanticipated complications of OTC (show OTC Proteins) supplementation.

  5. Src (show SRC Proteins) and p38 mitogen-activated protein kinase (show MAPK14 Proteins) activities are critical for regulating nSMase2 phosphorylation.

  6. Smpd3 was identified as a redox-sensitive enzyme, whose basal activity mediated changes in its oligomeric state.

  7. Data confirms a crucial pro-survival role for SMPD3 during embryonic development.

  8. Smpd3/nSMase2-ceramide-Akt (show AKT1 Proteins) signaling axis negatively regulates BMP-induced chondrocyte maturation.

  9. The H2O2-induced src (show SRC Proteins)/PDGFRbeta/SK1 (show SPHK1 Proteins) signaling cascade was impaired in nSMase2-deficient fro/fro cells and was rescued by exogenous C2Cer that activated src (show SRC Proteins)/PDGFRbeta/SK1 (show SPHK1 Proteins).

  10. Neutral sphingomyelinase 2 deficiency is associated with lung anomalies similar to emphysema.

Human Sphingomyelin Phosphodiesterase 3 (SMPD3) interaction partners

  1. Overexpression of Smpd3 induced cytodifferentiation of HPDL (show HPDL Proteins) cells, which could be suppressed by an inhibitor of its protein product, nSMase2. In addition,Smpd3 harboring a SNP (rs145616324) showed no activity and failed to induce cytodifferentiation of HPDL (show HPDL Proteins) cells. Together, these findings suggest that Smpd3 plays an important role in the osteoblastic differentiation of HPDL (show HPDL Proteins) cells.

  2. low oxLDL concentration triggers sprouting angiogenesis that involves ROS (show ROS1 Proteins)-induced activation of the neutral sphingomyelinase-2/sphingosine kinase-1 (show SPHK1 Proteins) pathway, and is effectively inhibited by GW4869.

  3. nSMase2 is a novel p53 (show TP53 Proteins) target gene, regulated by the DNA damage pathway to induce cell growth arrest.

  4. These results suggest that OTC (show OTC Proteins) is a potent stimulant of nSMase-2 expression and that there may be unanticipated complications of OTC (show OTC Proteins) supplementation.

  5. nSMase2 involvement in cellular processes including inflammatory signaling, exosome generation, cell growth, and apoptosis, which in turn play important roles in pathologies such as cancer metastasis, Alzheimer's disease

  6. SMPD3 plays an important role in the release of microRNAs into extracellular spaces.

  7. The data shows that nSMase3 acts as a signaling nSMase (show SMPD2 Proteins) in skeletal muscle that is essential for TNF (show TNF Proteins)-stimulated oxidant activity.

  8. This is the first report on the critical role of ceramide generated by nSMase2 in stem cell ciliogenesis and differentiation.

  9. We found upregulation of specific sphingolipid enzymes, namely sphingomyelin synthase 1 (SMS1 (show SGMS1 Proteins)), sphingomyelinase 3 (SMPD3), and glucosylceramide synthase (GCS (show UGCG Proteins)) in the endometrium of endometriotic women.

  10. The H2O2-induced src (show SRC Proteins)/PDGFRbeta/SK1 signaling cascade was impaired in nSMase2-deficient fro/fro cells and was rescued by exogenous C2Cer that activated src (show SRC Proteins)/PDGFRbeta/SK1.

SMPD3 Protein Profile

Protein Summary

Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Acts as a regulator of postnatal development and participates in bone and dentin mineralization. Overexpression enhances cell death, suggesting that it may be involved in apoptosis control. May be involved in IL-1-beta-induced JNK activation in hepatocytes. May act as a mediator in transcriptional regulation of NOS2/iNOS via the NF- kappa-B activation under inflammatory conditions.

Alternative names and synonyms associated with SMPD3

  • sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) (SMPD3)
  • sphingomyelin phosphodiesterase 3, neutral (Smpd3)
  • sphingomyelin phosphodiesterase 3, neutral membrane (Smpd3)
  • 4631433G07Rik protein
  • AI427456 protein
  • AW537966 protein
  • cca1 protein
  • fro protein
  • NSMASE2 protein

Protein level used designations for SMPD3

sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) , nSMase-2 , neutral sphingomyelinase 2 , neutral sphingomyelinase II , sphingomyelin phosphodiesterase 3 , confluent 3Y1 cell-associated 1 , confluent 3Y1 cell-associated protein 1 , nSMase2 , neutral sphingomyelin phosphodiesterase 3

GENE ID SPECIES
415619 Gallus gallus
58994 Mus musculus
94338 Rattus norvegicus
55512 Homo sapiens
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