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In patient with chronic granulomatous disease, a 5.8-kb, incomplete and partly exonized TMF1 transcript was identified in intron 1 of CYBB (show CYBB ELISA Kits), in opposite orientation to the host gene.
COG (show TG ELISA Kits) complex interacts with two different Rabs in addition to each end of the golgin "TATA element modulatory factor" (TMF).
These observations suggest critical roles for TMF in two Rab6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the endoplasmic reticulum.
Overexpression of TMF/ARA160 downregulates proangiogenic genes and attenuates the progression of prostate cancer xenografts.
The microtubule interacting domain (MIT) domain in TMF, along with microtubule integrity, are required for stable association of TMF with the Golgi apparatus.
Altered mucus secretion in TMF(-/-) mouse colons is accompanied by a reprogrammed intestinal microbiota, leading to a transmissible reduced sensitivity to induced colitis.
Data from knockout mice suggest that TMF/ARA160 participates in control of serum testosterone levels in males, and its absence results in major testicular and epididymal defects and abnormal spermatogenesis and Leydig cell proliferation.
absence of TMF/ARA160 renders the colonic mucus refractory to bacterial colonization and the large intestine less susceptible to the onset of colitis.
TMF/ARA160 is a key regulator which is essential for the onset of key events in the differentiation and maturation of mammalian sperm and whose absence severely compromises their ability to fertilize ova.
TMF/ARA160 is a BC-box-containing protein that mediates the degradation of Stat3 (show STAT3 ELISA Kits)
human homolog interacts with the androgen receptor and may act as a coactivator
TATA element modulatory factor 1
, TATA element modulatory factor
, TATA element modulatory factor-like
, androgen receptor coactivator 160 kDa protein
, androgen receptor-associated protein of 160 kDa